{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:39:14Z","timestamp":1790501954424,"version":"4.1.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Acta Veterinaria Hungarica"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Campylobacteriosis is mainly caused by infection with <jats:italic>Campylobacter jejuni<\/jats:italic> following consumption or handling of <jats:italic>Campylobacter<\/jats:italic>-contaminated poultry meat. The aim of this study was to investigate the effect of probiotic <jats:italic>Enterococcus faecium<\/jats:italic> AL41 on TGF-\u03b24 and IL-17 expression and on immunocompetent cell distribution after <jats:italic>C. jejuni<\/jats:italic> infection in broiler chicken, as a second part of the previous study of Karaffov\u00e1 et al. (2017). Accordingly, day-old chicks were randomly divided into four experimental groups of 10 chicks each (n = 10): control (C), <jats:italic>E. faecium<\/jats:italic> AL41 (EFAL41), <jats:italic>C. jejuni<\/jats:italic> CCM6191 (CJ), and combined <jats:italic>E. faecium<\/jats:italic> AL41 + <jats:italic>C. jejuni<\/jats:italic> CCM6191 (EFAL41 + CJ). Samples from the caecum were collected on days 4 and 7 post <jats:italic>Campylobacter infection<\/jats:italic> (dpi), for the isolation of mRNA of TGF-\u03b24, IL-17 and for immunohistochemistry. The relative mRNA expression of TGF-\u03b24 was upregulated in the combined (EFAL41 + CJ) group compared to other groups during both samplings, but the expression of IL-17 was downregulated. Similarly, the highest density of CD3+ was detected in the combined group at 7 dpi, but the number of IgA+ cells was increased in both groups with EFAL41. It was concluded that the EFAL41 probiotic <jats:italic>E. faecium<\/jats:italic> strain can modulate the expression of selected cytokines (upregulation of TGF-\u03b24 but downregulation of IL-17 relative expression), and activate IgA-producing cells in the caeca of chicks infected with <jats:italic>C. jejuni<\/jats:italic> CCM6191.<\/jats:p>","DOI":"10.1556\/004.2017.031","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T09:42:54Z","timestamp":1506591774000},"page":"317-326","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":11,"title":["Influence of oral application of Enterococcus faecium AL41 on TGF-\u03b24 and IL-17 expression and immunocompetent cell distribution in chickens challenged with Campylobacter jejuni"],"prefix":"10.1556","volume":"65","author":[{"given":"Alica","family":"Letnick\u00e1","sequence":"first","affiliation":[{"name":"Department of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and Pharmacy, Komensk\u00e9ho 73, 04181 Ko\u0161ice, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viera","family":"Karaffov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and Pharmacy, Komensk\u00e9ho 73, 04181 Ko\u0161ice, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikul\u00e1\u0161","family":"Levkut","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and Pharmacy, Komensk\u00e9ho 73, 04181 Ko\u0161ice, Slovak Republic"},{"name":"Institute of Neuroimmunology, Slovak Academy of Science, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viera","family":"Revajov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and Pharmacy, Komensk\u00e9ho 73, 04181 Ko\u0161ice, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"Herich","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Pathological Physiology, University of Veterinary Medicine and Pharmacy, Komensk\u00e9ho 73, 04181 Ko\u0161ice, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/65\/3\/article-p317.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/65\/3\/article-p317.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/65\/3\/article-p317.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T20:59:14Z","timestamp":1686171554000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/65\/3\/article-p317.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/004.2017.031","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}