{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:16:36Z","timestamp":1765422996962},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Acta Veterinaria Hungarica"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>The emergence of simultaneous resistance to multiple classes of antibiotics presents an increasing threat. Plasmid-borne multiresistance and integrative conjugative elements have been reported in <jats:italic>Pasteurella multocida<\/jats:italic>. We report an alternative strategy for the development of multiresistance observed in a <jats:italic>P. multocida<\/jats:italic> strain (Pm238) isolated from calf pneumonia. We identified genes integrated into the chromosomal DNA without known integrative and conjugative elements. These genes conferred resistance to streptomycin (<jats:italic>strA<\/jats:italic>), tetracycline (<jats:italic>tetB<\/jats:italic>), chloramphenicol (<jats:italic>catAIII<\/jats:italic>), and sulphonamides (<jats:italic>sulII<\/jats:italic>). We also detected mutation in the quinolone-resistance-determining regions of <jats:italic>parC<\/jats:italic>. No plasmids could be isolated from strain Pm238. These results suggest that <jats:italic>P. multocida<\/jats:italic> can accumulate multiple resistance determinants on the chromosome as single genes.<\/jats:p>","DOI":"10.1556\/004.2018.002","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T07:23:28Z","timestamp":1522135408000},"page":"12-19","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":9,"title":["Characterisation of a multiresistant Pasteurella multocida strain isolated from cattle"],"prefix":"10.1556","volume":"66","author":[{"given":"Barbara","family":"Ujv\u00e1ri","sequence":"first","affiliation":[{"name":"Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, P.O. Box 18, H-1581 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Makrai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Magyar","sequence":"additional","affiliation":[{"name":"Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, P.O. Box 18, H-1581 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/66\/1\/article-p12.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/66\/1\/article-p12.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/66\/1\/article-p12.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T21:03:32Z","timestamp":1686171812000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/66\/1\/article-p12.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1556\/004.2018.002","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}