{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:08:38Z","timestamp":1747199318763,"version":"3.40.5"},"reference-count":80,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to assess the physiological reference values for systemic and intrafollicular placental growth factor (PlGF) concentrations in different categories of follicular sizes in cycling mares, according to progesterone (P<jats:sub>4<\/jats:sub>) and oestradiol (E<jats:sub>2<\/jats:sub>) patterns. Sixty ovaries were taken after slaughter from 30 clinically healthy mares. Regarding their size, the follicles were classified into three different categories, i.e. small (20\u201330 mm), medium-sized (31\u201340 mm) and large (\u226541 mm), and follicular fluid (FF) was sampled from each single follicle. Intrafollicular PlGF concentrations were significantly increased in larger and medium-sized follicles compared to small follicles, and their values were 1.48 and 1.36 times higher than the systemic values, respectively. On the other hand, systemic PlGF concentrations were 1.3 times higher than those in the FF of follicles of small size. Intrafollicular P<jats:sub>4<\/jats:sub> concentrations were significantly higher in larger follicles than in small ones, and their concentrations were 6.74 and 3.42 times higher than the systemic values, respectively. Intrafollicular E<jats:sub>2<\/jats:sub> concentrations were significantly higher in large and medium-sized follicles than in follicles of small size, and their concentrations were 21.1, 15.4 and 8.35 times higher than the systemic values, respectively. Intrafollicular and systemic PlGF concentrations were strongly and positively correlated; nevertheless, no correlations between intrafollicular and systemic steroid hormones, PlGF and follicle diameters, PlGF and E<jats:sub>2<\/jats:sub>, or PlGF and P<jats:sub>4<\/jats:sub> were observed. This represents the first study to characterise systemic and intrafollicular PlGF concentrations in cycling normal mares, providing evidence that the bioavailability of this factor in follicles of medium and large sizes was higher than in small follicles, independently of steroid hormone concentrations. Further studies are needed to assess the presumable implications of PlGF in follicular angiogenesis in mares, similar to those already observed in women and primates.<\/jats:p>","DOI":"10.1556\/004.2020.00034","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T03:01:11Z","timestamp":1599274871000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Functional response of systemic and intrafollicular placental growth factor in cycling mares"],"prefix":"10.1556","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3168-0104","authenticated-orcid":true,"given":"Katiuska","family":"Satu\u00e9","sequence":"first","affiliation":[{"name":"1Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, CEU-Cardenal Herrera University, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esterina","family":"Fazio","sequence":"additional","affiliation":[{"name":"2Department of Veterinary Sciences, Veterinary Physiology Unit, Messina University, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Cravana","sequence":"additional","affiliation":[{"name":"2Department of Veterinary Sciences, Veterinary Physiology Unit, Messina University, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Quartuccio","sequence":"additional","affiliation":[{"name":"3Department of Veterinary Sciences, Physiopathology and Clinic of Reproduction Unit, Messina University, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Marcilla","sequence":"additional","affiliation":[{"name":"1Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, CEU-Cardenal Herrera University, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Medica","sequence":"additional","affiliation":[{"name":"2Department of Veterinary Sciences, Veterinary Physiology Unit, Messina University, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref131","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1095\/biolreprod61.1.31","article-title":"Follicle deviation and intrafollicular and systemic estradiol concentrations in mares","volume":"61","author":"Gastal","year":"1999","journal-title":"Biol. 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