{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:08:39Z","timestamp":1747199319979,"version":"3.40.5"},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2020,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical and pathological findings of a case of fatal disseminated toxoplasmosis in a captive brown-throated sloth (<jats:italic>Bradypus variegatus<\/jats:italic>) from the northern region of Brazil are reported. Clinical signs were nonspecific and included apathy, prostration, dyspnoea, and loss of appetite. Treatment with penicillin was attempted, but the animal died within five days of the onset of clinical signs. Microscopically, there was acute inflammation in the liver, spleen, and lungs associated with necrosis and a few cysts and extracytoplasmic tachyzoites, with a morphology compatible with<jats:italic>Toxoplasma gondii<\/jats:italic>. Tissue sections were submitted for immunohistochemistry that confirmed<jats:italic>T. gondii<\/jats:italic>as the aetiological agent. To the authors\u2019 knowledge, this is the first report of toxoplasmosis in<jats:italic>B. variegatus<\/jats:italic>.<\/jats:p>","DOI":"10.1556\/004.2020.00049","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T03:00:56Z","timestamp":1604113256000},"page":"285-288","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["Fatal disseminated toxoplasmosis in a brown-throated sloth (Bradypus variegatus) from Northern Brazil \u2013 Case report"],"prefix":"10.1556","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-1329","authenticated-orcid":true,"given":"Fabiano Jos\u00e9 Ferreira de","family":"Sant\u2019Ana","sequence":"first","affiliation":[{"name":"1Laborat\u00f3rio de Diagn\u00f3stico Patol\u00f3gico Veterin\u00e1rio, Universidade de Bras\u00edlia (UnB), Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana dos Santos","family":"Batista","sequence":"additional","affiliation":[{"name":"2Universidade Federal Rural da Amaz\u00f4nia (UFRA), Bel\u00e9m, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-4098","authenticated-orcid":true,"given":"Guilherme Reis","family":"Blume","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Diagn\u00f3stico Patol\u00f3gico Veterin\u00e1rio, Universidade de Bras\u00edlia (UnB), Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-8134","authenticated-orcid":true,"given":"Luciana","family":"Sonne","sequence":"additional","affiliation":[{"name":"3Faculdade de Veterin\u00e1ria, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-1495","authenticated-orcid":true,"given":"Claudio Severo Lombardo de","family":"Barros","sequence":"additional","affiliation":[{"name":"4Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref221","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0304-4017(01)00523-4","article-title":"Seroprevalence of Toxoplasma gondii in captive neotropical felids from Brazil","volume":"102","author":"Silva","year":"2001","journal-title":"Vet. 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Hyg."},{"key":"ref281","first-page":"76","article-title":"Clinical problems of sloths (Bradypus sp. and Choloepus sp.) in captivity","volume":"30","author":"Diniz","year":"1999","journal-title":"J. Zoo Wildl. Med."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.2460\/javma.1993.203.11.1556","article-title":"Histologically confirmed clinical toxoplasmosis in cats: 100 cases (1952\u20131990)","volume":"203","author":"Dubey","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref131","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1051\/parasite\/1989643200","article-title":"Leishmania (Viannia) shawi sp n., a parasite of monkey, sloths and procyonids in Amazon, Brazil","volume":"64","author":"Lainson","year":"1989","journal-title":"Ann. Parasitol. Hum. Comp."},{"key":"ref431","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/jmp.12314","article-title":"Detection of Toxoplasma gondii antibodies in captive non-human primates in Amazon region, Brazil","volume":"46","author":"Minervino","year":"2017","journal-title":"J. Med. Primatol."},{"key":"ref331","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jcpa.2016.02.002","article-title":"Fatal systemic Toxoplasma gondii infection in a red squirrel (Sciurus vulgaris), a Swinhoe\u2019s striped squirrel (Tamiops swinhoei) and a New World porcupine (Erethizontidae sp.)","volume":"154","author":"Fayyad","year":"2016","journal-title":"J. Comp. Pathol."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jcpa.2016.02.002","article-title":"Fatal systemic Toxoplasma gondii infection in a red squirrel (Sciurus vulgaris), a Swinhoe\u2019s striped squirrel (Tamiops swinhoei) and a New World porcupine (Erethizontidae sp.)","volume":"154","author":"Fayyad","year":"2016","journal-title":"J. Comp. Pathol."},{"key":"ref101","first-page":"53","article-title":"Apicomplexa, Toxoplasma and hammondia","volume-title":"An Atlas of Protozoan Parasites in Animal Tissues","author":"Gardiner","year":"1998"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00009629","article-title":"Coccidia of Brazilian edentates: Eimeria cyclopei new species from the silky anteater Cyclopes didactylus and Eimeria choloepi new species from the two-toed sloth Choloepus didactylus","volume":"4","author":"Lainson","year":"1982","journal-title":"Syst. Parasitol."},{"key":"ref181","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/jmp.12314","article-title":"Detection of Toxoplasma gondii antibodies in captive non-human primates in Amazon region, Brazil","volume":"46","author":"Minervino","year":"2017","journal-title":"J. Med. Primatol."},{"key":"ref381","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1051\/parasite\/1989643200","article-title":"Leishmania (Viannia) shawi sp n., a parasite of monkey, sloths and procyonids in Amazon, Brazil","volume":"64","author":"Lainson","year":"1989","journal-title":"Ann. Parasitol. Hum. Comp."},{"key":"ref01","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/S0100-736X2013000200004","article-title":"Causes of bovine abortion diagnosed at the veteirnary pathology section of the UFRGS between 2003 and 2011 [in Portuguese]","volume":"33","author":"Antoniassi","year":"2013","journal-title":"Pesqui. Vet. 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Pathol."},{"key":"ref341","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vetpar.2009.09.044","article-title":"Factors affecting seroprevalence of Toxoplasma gondii in the endangered Iberian lynx (Lynx pardinus)","volume":"167","author":"Garcia-Bocanegra","year":"2010","journal-title":"Vet. Parasitol."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2307\/3278605","article-title":"Toxoplasmosis of the two-toed sloth, Choloepus didactylus, in Brazil","volume":"59","author":"Shaw","year":"1973","journal-title":"J. Parasitol."},{"key":"ref441","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4067\/S0717-95022012000100012","article-title":"Systemic toxoplasmosis in a captive red kangaroo (Macropus rufus)","volume":"30","author":"Ochoa-Amaya","year":"2012","journal-title":"Int. J. Morphol."},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/030098589703400101","article-title":"Epizootic disseminated toxoplasmosis in captive slender-tailed meerkats (Suricata suricatta)","volume":"34","author":"Sall\u00e9s","year":"1997","journal-title":"Vet. Pathol."},{"key":"ref321","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/030098589902700605","article-title":"Lesions in fetal pigs with transplacentally-induced toxoplasmosis","volume":"27","author":"Dubey","year":"1990","journal-title":"Vet. Pathol."},{"key":"ref91","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vetpar.2009.09.044","article-title":"Factors affecting seroprevalence of Toxoplasma gondii in the endangered Iberian lynx (Lynx pardinus)","volume":"167","author":"Garcia-Bocanegra","year":"2010","journal-title":"Vet. Parasitol."},{"key":"ref61","first-page":"755","article-title":"Toxoplasmosis and neosporosis","volume-title":"Infectious Diseases of the Dog and Cat","author":"Dubey","year":"2006"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/jcpa.2001.0495","article-title":"Acute disseminated toxoplasmosis in a captive three-toed sloth (Bradypus tridactylus)","volume":"125","author":"T\u00fary","year":"2001","journal-title":"J. Comp. Pathol."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/s1984-29612016076","article-title":"Infection with Toxoplasma gondii in a red kangaroo (Macropus rufus) and a Patagonia mara (Dolichotis patagonum) in captivity","volume":"25","author":"D\u00edaz-Ayala","year":"2016","journal-title":"Braz. J. Vet. Parasitol."},{"key":"ref31","first-page":"76","article-title":"Clinical problems of sloths (Bradypus sp. and Choloepus sp.) in captivity","volume":"30","author":"Diniz","year":"1999","journal-title":"J. Zoo Wildl. Med."},{"key":"ref191","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4067\/S0717-95022012000100012","article-title":"Systemic toxoplasmosis in a captive red kangaroo (Macropus rufus)","volume":"30","author":"Ochoa-Amaya","year":"2012","journal-title":"Int. J. Morphol."},{"key":"ref161","first-page":"31","article-title":"Occurrence of Salmonella in wild edentates in the Amazon region of Brazil","volume":"27","author":"Loureiro","year":"1985","journal-title":"Rev. Latinoam. Microbiol."},{"key":"ref351","first-page":"53","article-title":"Apicomplexa, Toxoplasma and hammondia","volume-title":"An Atlas of Protozoan Parasites in Animal Tissues","author":"Gardiner","year":"1998"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1079\/AHR2005100","article-title":"Biology and epidemiology of Toxoplasma gondii in man and animals","volume":"6","author":"Hill","year":"2005","journal-title":"Anim. Health Res. 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Pathol."},{"key":"ref301","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.2460\/javma.1993.203.11.1556","article-title":"Histologically confirmed clinical toxoplasmosis in cats: 100 cases (1952\u20131990)","volume":"203","author":"Dubey","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref111","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jcpa.2015.08.004","article-title":"Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena)","volume":"153","author":"Herder","year":"2015","journal-title":"J. Comp. Pathol."},{"key":"ref361","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jcpa.2015.08.004","article-title":"Fatal disseminated Toxoplasma gondii infection in a captive harbour porpoise (Phocoena phocoena)","volume":"153","author":"Herder","year":"2015","journal-title":"J. Comp. Pathol."},{"key":"ref251","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/S0100-736X2013000200004","article-title":"Causes of bovine abortion diagnosed at the veteirnary pathology section of the UFRGS between 2003 and 2011 [in Portuguese]","volume":"33","author":"Antoniassi","year":"2013","journal-title":"Pesqui. Vet. 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Pathol."},{"volume-title":"Toxoplasmosis of Animals and Humans","year":"2010","author":"Dubey","key":"ref41"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/s1984-29612016076","article-title":"Infection with Toxoplasma gondii in a red kangaroo (Macropus rufus) and a Patagonia mara (Dolichotis patagonum) in captivity","volume":"25","author":"D\u00edaz-Ayala","year":"2016","journal-title":"Braz. J. Vet. Parasitol."},{"key":"ref421","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.4269\/ajtmh.1983.32.1251","article-title":"Vertebrate hosts and vectors of Trypanosoma rangeli in Amazon basin of Brazil","volume":"32","author":"Miles","year":"1983","journal-title":"J. Trop. Med. 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