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The Mann\u2013Whitney rank test was used to demonstrate the differences in Mn concentrations, as well as other haematological and biochemical parameters between groups. In dogs in Group 2 with cerebral babesiosis, as compared to dogs in Groups 1 and 3, a statistically significant increase in serum Mn concentration was shown (<jats:italic>P<\/jats:italic> = 0.002 and <jats:italic>P<\/jats:italic> = 0.029) that may have been associated with the development of anaemia and\/or impairment of liver function. Given the well-established neurotoxic effects of Mn in humans, experimental rodents and primates, additional studies on the role of Mn in the pathogenesis of the cerebral form of canine babesiosis are warranted.<\/jats:p>","DOI":"10.1556\/004.2020.00053","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T03:01:19Z","timestamp":1612321279000},"page":"354-360","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Elevated serum manganese concentration in dogs as a possible predisposing factor of cerebral babesiosis in dogs"],"prefix":"10.1556","volume":"68","author":[{"given":"Oliwier","family":"Teodorowski","sequence":"first","affiliation":[{"name":"1\u2018Teodorowscy\u2019 Veterinary Clinic, Miko\u0142\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Adaszek","sequence":"additional","affiliation":[{"name":"2Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka str. 30, 20-612 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Erman Or","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Dokuzeyl\u00fcl","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev Meltem","family":"Ercan","sequence":"additional","affiliation":[{"name":"4Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Fatih, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Tarhan","sequence":"additional","affiliation":[{"name":"4Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Fatih, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-2558","authenticated-orcid":true,"given":"Marta","family":"Staniec","sequence":"additional","affiliation":[{"name":"2Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka str. 30, 20-612 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw","family":"Winiarczyk","sequence":"additional","affiliation":[{"name":"2Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka str. 30, 20-612 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref471","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0195-5616(03)00039-1","article-title":"Canine babesiosis","volume":"33","author":"Boozer","year":"2003","journal-title":"Vet. 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