{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:49:51Z","timestamp":1784299791986,"version":"3.55.0"},"reference-count":28,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been shown that gintonin, isolated from<jats:italic>Panax ginseng<\/jats:italic>, can promote rapid corneal wound healing. We aimed to elucidate the underlying mechanism and investigated whether gintonin affects the concentration of the extracellular matrix remodelling factor matrix metalloproteinase-9 (MMP-9) in tears during rabbit corneal wound healing<jats:italic>in vivo<\/jats:italic>. Twelve eyes (six rabbits) were divided equally into three groups. All eyes underwent corneal de-epithelialisation. The control group received Tearin Free sodium hyaluronate 0.1%, the solcoseryl group received solcoseryl-120 concentrate, and the gintonin group received 2.5 mg gintonin in sodium hyaluronate 0.1%. All preparations were administered for 5 days and the concentration of MMP-9 was measured in tears via ELISA on days 0, 1, and 5. MMP-9 concentrations in all groups were increased at day 1 and reduced at day 5. Of note, we found a significant change over the time frame for the gintonin group (<jats:italic>P<\/jats:italic>&lt; 0.05) but not for the control or solcoseryl groups (<jats:italic>P<\/jats:italic>&gt; 0.05) Moreover, increased MMP-9 levels between days 0 and 1, and their reduction between days 1 and 5, were significant in the gintonin group compared to those in the other groups (<jats:italic>P<\/jats:italic>&lt; 0.05); however, and once more, these changes were not significant between the control and solcoseryl groups (<jats:italic>P<\/jats:italic>&gt; 0.05). In conclusion, gintonin increases the concentration of MMP-9 rapidly within a day of injury, and decreasing it thereafter.<\/jats:p>","DOI":"10.1556\/004.2020.00062","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T10:17:22Z","timestamp":1613125042000},"page":"364-369","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Effect of gintonin on matrix metalloproteinase-9 concentration in tears during corneal wound healing in rabbits"],"prefix":"10.1556","volume":"68","author":[{"given":"Ha-Eun","family":"Lee","sequence":"first","affiliation":[{"name":"1Department of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-6269","authenticated-orcid":true,"given":"Joon-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"1Department of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Wuk","family":"Jeong","sequence":"additional","affiliation":[{"name":"2Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Yeol","family":"Nah","sequence":"additional","affiliation":[{"name":"3Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref211","first-page":"976","article-title":"Diseases and surgery of the canine cornea and sclera","volume-title":"Veterinary Ophthalmology","author":"Ledbetter","year":"2013"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3892\/ijo.2012.1709","article-title":"Suppression of metastasis of intravenously-inoculated B16\/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition","volume":"42","author":"Hwang","year":"2013","journal-title":"Int. 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