{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:08:44Z","timestamp":1747199324218,"version":"3.40.5"},"reference-count":76,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2021,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)\u2013pyometra complex. Group 1 (<jats:italic>n<\/jats:italic> = 10) included bitches with open cervix pyometra, while Group 2 (<jats:italic>n<\/jats:italic> = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. IGF-2 immunopositivity was observed in the endometrial glandular epithelium in both groups. Additionally, interstitial fibroblasts and macrophages in the endometrium were also positive in Group 1. The concentration of plasma IGF-2 was higher in Group 1 than in Group 2 (<jats:italic>P<\/jats:italic> &lt; 0.05). The concentration was positively correlated with IGF-2 expression in the endometrial glands (<jats:italic>r<\/jats:italic> = 0.926; <jats:italic>P<\/jats:italic> &lt; 0.001) in Group 1. However, a negative correlation was present between plasma IGF-2 concentration and IGF-2 expression in the interstitial endocrine cells of the ovary in Group 1 (<jats:italic>r<\/jats:italic> = \u22120.652; <jats:italic>P<\/jats:italic> &lt; 0.05). The results suggest that IGF-2 plays an important role during the inflammatory process occurring in bitches with CEH\u2013pyometra complex as well as in the endometrium of healthy bitches in dioestrus.<\/jats:p>","DOI":"10.1556\/004.2021.00013","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T03:01:25Z","timestamp":1619233285000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia\u2013pyometra"],"prefix":"10.1556","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-3531","authenticated-orcid":true,"given":"Nilg\u00fcn","family":"G\u00fcltiken","sequence":"first","affiliation":[{"name":"1Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Yarim","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl Fatma","family":"Yarim","sequence":"additional","affiliation":[{"name":"3Department of Biochemistry, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"S\u00f6zmen","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvan","family":"Anadol","sequence":"additional","affiliation":[{"name":"4Laboratory Animal Breeding and Experimental Research Center, University of Gazi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Findik","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref131","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/acta.0.1040167","article-title":"Progesterone-controlled growth hormone overproduction and naturally occurring canine diabetes and acromegaly","volume":"104","author":"Eigenmann","year":"1983","journal-title":"Acta Endocrinol. 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