{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T20:00:43Z","timestamp":1749412843476,"version":"3.37.3"},"reference-count":33,"publisher":"Akademiai Kiado Zrt.","issue":"3-4","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012705","name":"Warsaw University of Life Sciences","doi-asserted-by":"crossref","award":["505-10-023500-Q00375-99"],"award-info":[{"award-number":["505-10-023500-Q00375-99"]}],"id":[{"id":"10.13039\/501100012705","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to assess the usefulness of monitoring inter-alpha trypsin inhibitor heavy chain 4 (ITIH4) and haptoglobin (Hp) in peripheral and local blood in canine pyometra, and evaluation the relationships among acute phase proteins (APPs), systemic inflammatory response syndrome (SIRS) and the presence of bacteria. The material was collected from bitches with pyometra and from healthy ones. Blood was taken from the cephalic and uterine veins. APPs levels were quantified by ELISA. In the peripheral circulation, the Hp was higher in animals with open-cervix pyometra (OCP) than in the closed-cervix pyometra (CCP) and the control group. The Hp concentration was not correlated with age, with the presence of SIRS or with the type of bacteria (Gram-negative, Gram-positive or mixed flora). The ITIH4 concentrations in the peripheral blood did not differ significantly in the cases of pyometra. The Hp concentration in the local circulation increased in the OCP but not in the CCP groups, although the histopathological changes in the endometrium were similar. Peripheral Hp concentrations may be a useful tool in differentiating between the types of pyometra.<\/jats:p>","DOI":"10.1556\/004.2023.00852","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T13:02:46Z","timestamp":1702472566000},"page":"174-182","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Relationships between haptoglobin and inter-alpha trypsin inhibitor heavy chain 4 levels in\u00a0local and peripheral blood and systemic inflammatory response syndrome in bitches with\u00a0pyometra"],"prefix":"10.1556","volume":"71","author":[{"given":"Szymon","family":"Kanafa","sequence":"first","affiliation":[{"name":"Department of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-366X","authenticated-orcid":true,"given":"Kinga","family":"Domrazek","sequence":"additional","affiliation":[{"name":"Department of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"D\u0105browski","sequence":"additional","affiliation":[{"name":"Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Soler","sequence":"additional","affiliation":[{"name":"Acuvet Biotech, C\/ Bari 25, 50197, Zaragoza, Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Kaszak","sequence":"additional","affiliation":[{"name":"Department of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Witkowska-Pi\u0142aszewicz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabella","family":"Dolka","sequence":"additional","affiliation":[{"name":"Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-4844","authenticated-orcid":true,"given":"Piotr","family":"Jurka","sequence":"additional","affiliation":[{"name":"Department of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Haptoglobin. 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C., de Sousa, D. B., da Silva, M. F., do Arcaten, N. and Amaral, A. V. C. (2021): Uterine artery hemodynamics in female dogs with open- and closed-cervix pyometra. Research, Society and Development, [S. l.]. 10(11), p. e257101119287. https:\/\/doi.org\/10.33448\/rsd-v10i11.19287."},{"key":"bib34","series-title":"Eur. J. Biochem.","first-page":"339","article-title":"Inter-alpha-trypsininhibitor proteoglycan family. A group of proteins binding and stabilizing theextracellular matrix","volume":"252","author":"Bost, F.","year":"1998","unstructured":"Bost, F., Diarra-Mehrphour, M. and Martin, J. P. (1998): Inter-alpha-trypsininhibitor proteoglycan family. A group of proteins binding and stabilizing theextracellular matrix. Eur. J. Biochem. 252, 339\u2013346."},{"key":"B5","series-title":"Vet. Clin. Pathol.","first-page":"85","article-title":"Acute phase proteins in dogs and cats: current knowledge and future perspectives","volume":"34","author":"Ceron, J. 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