{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:05:45Z","timestamp":1782821145775,"version":"3.54.5"},"reference-count":24,"publisher":"Akademiai Kiado Zrt.","issue":"2","funder":[{"name":"Inner Mongolia Agricultural University 2022 College Student Innovation Training Plan Project","award":["202210129023"],"award-info":[{"award-number":["202210129023"]}]},{"name":"Discipline Project of College of Veterinary Medicine, Inner Mongolia Agricultural University","award":["SYKJYB202304"],"award-info":[{"award-number":["SYKJYB202304"]}]},{"DOI":"10.13039\/501100002797","name":"Universities of Inner Mongolia Autonomous Region","doi-asserted-by":"crossref","award":["NJZY22486"],"award-info":[{"award-number":["NJZY22486"]}],"id":[{"id":"10.13039\/501100002797","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to study the species and functions of micro (mi)RNAs in the exosomes of camel milk, non-coding small (s)RNAs were sequenced and identified by Illumina sequencing technology, and the miRNA fraction was analysed by bioinformatics. After quality control, the average length of sRNA of camel milk exosomes was 18\u201324 nucleotides. A total of 2,659 miRNAs were identified, including 2,458 known, and 201 new miRNAs. Among the known miRNAs, miR-148a and let-7i had the highest expression levels. The results of gene ontology enrichment analysis indicated that the target genes of camel milk exosome miRNAs were involved in multicellular organismal, catabolic and other biological processes. They play role in the extracellular region, in the cytoskeleton and other cell components, in protein binding, but also have structural molecule activity and other molecular functions. According to the results of the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, the target genes of camel milk exosome miRNAs are involved in Alzheimer's disease, non-alcoholic fatty liver disease, <jats:italic>Staphylococcus aureus<\/jats:italic> infection and other pathological pathways. We speculate that the reported\u00a0beneficial effect of camel milk in various pathologic conditions may be closely related to the regulatory function of the exosomal miRNAs exerted on target genes of the diseases.<\/jats:p>","DOI":"10.1556\/004.2023.00869","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T11:35:47Z","timestamp":1695123347000},"page":"82-85","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":7,"title":["Sequencing and analysis of micro RNAs in\u00a0camel\u00a0milk exosomes"],"prefix":"10.1556","volume":"71","author":[{"given":"Rinile","family":"Wu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuerong","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3572-7491","authenticated-orcid":true,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010011, China"},{"name":"Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, 010011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"J. 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