{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:08:57Z","timestamp":1747199337005,"version":"3.40.5"},"reference-count":17,"publisher":"Akademiai Kiado Zrt.","issue":"3-4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present paper reports on the clinical efficacy and optimal clinical dose of medetomidine for sedation of young cows during dehorning surgery. Medical records of 24 female Holstein cows that underwent dehorning surgery were used in this study. In four groups, the sedation of animals was\u00a0carried out by one of the four intravenous treatments: 0.1\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> xylazine (Xyl group, <jats:italic>n<\/jats:italic> = 6), 5.0\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup> medetomidine (5.0 Med group, <jats:italic>n<\/jats:italic> = 6), 10.0\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup> medetomidine (10.0 Med group, <jats:italic>n<\/jats:italic> = 6) or 20.0\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup> medetomidine (20.0 Med group, <jats:italic>n<\/jats:italic> = 6). The clinical sedation score (CSS) and heart rate (HR) were recorded. The CSSs after intravenous administration of each \u03b1<jats:sub>2<\/jats:sub>-adrenergic receptor agonist\u00a0increased rapidly and peaked at 12.5 (10.0\u201316.0) at <jats:italic>t<\/jats:italic> = 20\u2009min in the Xyl group, 11.5 (10.0\u201315.0) at <jats:italic>t<\/jats:italic> = 10\u2009min in the 5.0 Med group, 16.0 (14.0\u201316.0) at <jats:italic>t<\/jats:italic> = 20\u2009min in the 10.0 Med group and 16.0\u00a0(14.0\u00a0\u2013 16.0) at <jats:italic>t<\/jats:italic> = 20\u2009min in the 20.0 Med group. A similar degree of bradycardia was observed after every sedative treatment. We conclude that the intravenous administration of 10.0\u201320.0\u2009\u03bcg\u2009kg<jats:sup>\u22121<\/jats:sup> medetomidine is appropriate for sedation of young cows without severe side effects.<\/jats:p>","DOI":"10.1556\/004.2023.00919","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T15:08:08Z","timestamp":1700838488000},"page":"142-146","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Optimal clinical dose of medetomidine for sedation of young cows during dehorning surgery"],"prefix":"10.1556","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2197-4117","authenticated-orcid":true,"given":"Kenji","family":"Tsukano","sequence":"first","affiliation":[{"name":"Aomori Agricultural Mutual Aid Association, 1-495 Aza Tounosawayama, Touhokumachi, Kamikita-gun, Aomori, 039-2654, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Hokkaido Agricultural Mutual Aid Association, 74-2 Higashimae, Hokuto, Hokkaido, 041-1214, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunnkyoudai, Ebetsu, Hokkaido, 069-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Farm Animal Surgery","first-page":"60","article-title":"Sedation, general anesthesia, and analgesia","author":"Boesch, J. 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