{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:33:37Z","timestamp":1763991217902,"version":"3.45.0"},"reference-count":41,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2025,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tertiary hyperparathyroidism (THPT) is rarely discussed in animals. This study aimed to report a case of tertiary renal hyperparathyroidism in a dog. A 16-year-old spayed female, Shih Tzu, previously diagnosed with stage 2 chronic kidney disease, presented increased levels of serum urea, creatinine, total calcium, ionized calcium, phosphorus and PTH, indicating THPT. Clinical treatment for the renal condition was initiated and cinacalcet hydrochloride (0.5\u2009mg*kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , orally, once daily for 7 days, followed by 1\u2009mg*kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , orally, once daily for 7 days) was administered to correct the hormonal disorders. PTH, total calcium and ionized concentrations decreased by 56%, 76% and 15%, respectively, in 14\u00a0days. However, exacerbation of the uremic crisis was observed, leading to death 26 days after the initiation of the medication. This report appears to be the first to comprehensively discuss THPT in veterinary medicine. The shorter life expectancy of these animals compared to that of humans may be a determining factor for the low prevalence of THPT in dogs. The tendency toward a reduction in PTH, total calcium and ionized calcium achieved after the initiation of cinacalcet hydrochloride use encourages the development of further clinical studies to investigate its application in animals.\n                  <\/jats:p>","DOI":"10.1556\/004.2025.01177","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:28:03Z","timestamp":1758878883000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Tertiary hyperparathyroidism in a dog \u2013 Case\u00a0report"],"prefix":"10.1556","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-5662","authenticated-orcid":true,"given":"Diego","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, S\u00e3o Paulo State University (UNESP), Rua Prof. Doutor Walter Maur\u00edcio Correa, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner Silveira","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, S\u00e3o Paulo State University (UNESP), Rua Prof. Doutor Walter Maur\u00edcio Correa, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane Aparecida Martiniano","family":"de P\u00e1dua","sequence":"additional","affiliation":[{"name":"Department of Preventive Veterinary Medicine, School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Presidente Carlos Luz, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Soares","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, S\u00e3o Paulo State University (UNESP), Rua Prof. Doutor Walter Maur\u00edcio Correa, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karla","family":"de Lima Silva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics, Faculty of Veterinary Medicine and Animal Science, Federal University of Lavras (UFLA), Avenida Sul, Lavras, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscylla Tatiana Chalfun","family":"Guimar\u00e3es Okamoto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science, S\u00e3o Paulo State University (UNESP), Rua Prof. Doutor Walter Maur\u00edcio Correa, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Bernardes","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics, Faculty of Veterinary Medicine and Animal Science, Federal University of Lavras (UFLA), Avenida Sul, Lavras, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"issue":"6","key":"B1","series-title":"J.\u00a0Vet. Emerg. Crit. Care","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/j.1476-4431.2011.00679.x","article-title":"A clinical review of peritoneal dialysis","volume":"21","author":"Bersenas, A. M. E.","year":"2011","unstructured":"Bersenas, A. M. E. (2011): A clinical review of peritoneal dialysis. J.\u00a0Vet. Emerg. Crit. Care 21(6), 605\u2013617. 10.1111\/j.1476-4431.2011.00679.xhttps:\/\/doi.org\/10.1111\/j.1476-4431.2011.00679.x"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031633","article-title":"Cinacalcet for secondary hyperparathyroidism in hemodialysis patients","author":"Block, G. A.","year":"2004","unstructured":"Block, G. A., Martin, K. J., de Francisco, A. L., Turner, S. A., Avram, M. M., Suranyi, M. G., et al. (2004): Cinacalcet for secondary hyperparathyroidism in hemodialysis patients. 10.1056\/NEJMoa031633https:\/\/doi.org\/10.1056\/NEJMoa031633"},{"issue":"3","key":"B2","series-title":"Biochem. Pharmacol.","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.bcp.2010.04.002","article-title":"Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR)","volume":"80","author":"Brown, E. M.","year":"2010","unstructured":"Brown, E. M. (2010): Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR). Biochem. Pharmacol. 80(3), 297\u2013307. 10.1016\/j.bcp.2010.04.002https:\/\/doi.org\/10.1016\/j.bcp.2010.04.002"},{"key":"B3","series-title":"Best Pract. Res. Clin. Endocrinol. Metab.","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.beem.2015.06.001","article-title":"Vitamin D signaling in calcium and bone homeostasis: a delicate balance","volume":"29","author":"Carmeliet, G.","year":"2015","unstructured":"Carmeliet, G., Dermauw, V. and Bouillon, R. (2015): Vitamin D signaling in calcium and bone homeostasis: a delicate balance. Best Pract. Res. Clin. Endocrinol. Metab. 29, 621\u2013663. 10.1016\/j.beem.2015.06.001https:\/\/doi.org\/10.1016\/j.beem.2015.06.001"},{"issue":"4","key":"B4","series-title":"Indian J. Endocrinol. Metab","doi-asserted-by":"publisher","first-page":"391","DOI":"10.4103\/ijem.IJEM_292_19","article-title":"Secondary and tertiary hyperparathyroidism in chronic kidney disease: an endocrine and renal perspective","volume":"23","author":"Chandran, M.","year":"2019","unstructured":"Chandran, M. and Wong, J. (2019): Secondary and tertiary hyperparathyroidism in chronic kidney disease: an endocrine and renal perspective. Indian J. Endocrinol. Metab. 23(4), 391\u2013399. 10.4103\/ijem.IJEM_292_19https:\/\/doi.org\/10.4103\/ijem.IJEM_292_19"},{"key":"B5","series-title":"Front. Vet. Sci.","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3389\/fvets.2019.00276","article-title":"Severity of ionized hypercalcemia and hypocalcemia is associated with etiology in dogs and cats","volume":"6","author":"Coady, M.","year":"2019","unstructured":"Coady, M., Fletcher, D. J. and Goggs, R. (2019): Severity of ionized hypercalcemia and hypocalcemia is associated with etiology in dogs and cats. Front. Vet. Sci. 6, 276. 10.3389\/fvets.2019.00276https:\/\/doi.org\/10.3389\/fvets.2019.00276"},{"issue":"1","key":"B6","series-title":"Vet. Clin. N. Am.","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cvsm.2010.10.002","article-title":"Peritoneal dialysis in veterinary medicine","volume":"41","author":"Cooper, R. L.","year":"2011","unstructured":"Cooper, R. L. and Labato, M. A. (2011): Peritoneal dialysis in veterinary medicine. Vet. Clin. N. Am. 41(1), 91\u2013113. 10.1016\/j.cvsm.2010.10.002https:\/\/doi.org\/10.1016\/j.cvsm.2010.10.002"},{"issue":"1","key":"B7","series-title":"J. Vet. Intern. Med.","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1939-1676.2009.0415.x","article-title":"Calcium and phosphorus homeostasis in dogs with spontaneous chronic kidney disease at different stages of severity","volume":"24","author":"Cortadellas, O.","year":"2010","unstructured":"Cortadellas, O., Fern\u00e1ndez del Palacio, M. J., Talavera, J. and Bay\u00f3n, A. (2010): Calcium and phosphorus homeostasis in dogs with spontaneous chronic kidney disease at different stages of severity. J. Vet. Intern. Med. 24(1), 73\u201379. 10.1111\/j.1939-1676.2009.0415.xhttps:\/\/doi.org\/10.1111\/j.1939-1676.2009.0415.x"},{"key":"B8","series-title":"IRIS Grading of Acute Kidney Injury (AKI)","author":"International Renal Interest Society (IRIS)","year":"2016","unstructured":"International Renal Interest Society (IRIS). (2016). IRIS Grading of Acute Kidney Injury (AKI). https:\/\/www.iris-kidney.com\/pdf\/4_ldc-revised-grading-of-acute-kidney-injury.pdf."},{"key":"B9","series-title":"Staging of CKD Modified","author":"International Renal Interest Society (IRIS)","year":"2023","unstructured":"International Renal Interest Society (IRIS). (2023). Staging of CKD Modified. https:\/\/www.iris-kidney.com\/pdf\/2_IRIS_Staging_of_CKD_2023.pdf."},{"issue":"7","key":"B10","series-title":"Br. J. Surg.","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1002\/bjs.10554","article-title":"Systematic review of surgical and medical treatment for tertiary hyperparathyroidism","volume":"104","author":"Dulfer, R. R.","year":"2017","unstructured":"Dulfer, R. R., Franssen, G. J. H., Hesselink, D. A., Hoorn, E. J., van Eijck, C. H. J. and Van-Ginhoven, T. M. (2017): Systematic review of surgical and medical treatment for tertiary hyperparathyroidism. Br. J. Surg. 104(7), 804\u2013813. 10.1002\/bjs.10554https:\/\/doi.org\/10.1002\/bjs.10554"},{"key":"B11","series-title":"Canine and Feline Endocrinology","first-page":"579","article-title":"Hypercalcemia and primary hyperparathyroidism","author":"Feldman, E. C.","year":"2014","unstructured":"Feldman, E. C. (2014): Hypercalcemia and primary hyperparathyroidism. In Canine and Feline Endocrinology, 4th ed. Saunders, pp. 579\u2013624."},{"issue":"6","key":"B12","series-title":"Vet. Clin. North Am. Small Anim. Pract.","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.cvsm.2016.06.003","article-title":"Update on mineral and bone disorders in chronic kidney disease","volume":"46","author":"Foster, J. D.","year":"2016","unstructured":"Foster, J. D. (2016): Update on mineral and bone disorders in chronic kidney disease. Vet. Clin. North Am. Small Anim. Pract. 46(6), 1131\u20131149. 10.1016\/j.cvsm.2016.06.003https:\/\/doi.org\/10.1016\/j.cvsm.2016.06.003"},{"issue":"5","key":"B13","series-title":"J. Bone Miner. Metab.","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00774-011-0298-0","article-title":"Fibroblast growth factor 23 as a phosphotropic hormone and beyond","volume":"29","author":"Fukumoto, S.","year":"2011","unstructured":"Fukumoto, S. and Shimizu, Y. (2011): Fibroblast growth factor 23 as a phosphotropic hormone and beyond. J. Bone Miner. Metab. 29(5), 507\u2013514. 10.1007\/s00774-011-0298-0https:\/\/doi.org\/10.1007\/s00774-011-0298-0"},{"issue":"2","key":"B14","series-title":"J. Vet. Emerg. Crit. Care","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/vec.12032","article-title":"The\u00a0role of phosphorus in the pathophysiology of chronic kidney disease","volume":"23","author":"Geddes, R. F.","year":"2013","unstructured":"Geddes, R. F., Finch, N. C., Syme, H. M. and Elliott, J. (2013): The\u00a0role of phosphorus in the pathophysiology of chronic kidney disease. J. Vet. Emerg. Crit. Care 23(2), 122\u2013133. 10.1111\/vec.12032https:\/\/doi.org\/10.1111\/vec.12032"},{"key":"B15","series-title":"Treatise on Nephrology and Urology in Dogs and Cats","first-page":"315","article-title":"Secondary renal hyperparathyroidism (bone metabolic disorders in chronic kidney disease)","author":"Giovaninni, L. H.","year":"2021","unstructured":"Giovaninni, L. H. and Messas, N. B. (2021): Secondary renal hyperparathyroidism (bone metabolic disorders in chronic kidney disease). In L. Z. Crivellenti and L. H. Giovaninni (eds), Treatise on Nephrology and Urology in Dogs and Cats. Medvet, pp.\u00a0315\u2013317."},{"issue":"4","key":"B16","series-title":"Endocrinol. Metab. Clin. North Am.","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.ecl.2018.07.003","article-title":"Physiology of parathyroid hormone","volume":"47","author":"Goltzman, D.","year":"2018","unstructured":"Goltzman, D. (2018): Physiology of parathyroid hormone. Endocrinol. Metab. Clin. North Am. 47(4), 743\u2013758. 10.1016\/j.ecl.2018.07.003https:\/\/doi.org\/10.1016\/j.ecl.2018.07.003"},{"key":"B17","series-title":"Front. Horm. Res.","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000486060","article-title":"Physiology of the calcium-parathyroid hormone-vitamin D axis","volume":"50","author":"Goltzman, D.","year":"2018","unstructured":"Goltzman, D., Mannstad, T. and Marcocci, C. (2018): Physiology of the calcium-parathyroid hormone-vitamin D axis. Front. Horm. Res. 50, 1\u201313. 10.1159\/000486060https:\/\/doi.org\/10.1159\/000486060"},{"issue":"6","key":"B18","series-title":"Am. J. Kidney Dis.","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1053\/j.ajkd.2004.08.029","article-title":"Pharmacokinetics, pharmacodynamics, and safety of cinacalcet hydrochloride in hemodialysis patients at doses up to 200 mg once daily","volume":"44","author":"Harris, R. Z.","year":"2004","unstructured":"Harris, R. Z., Padhi, D., Marbury, T. C., Noveck, R. J., Salfi, M. and Sullivan, J. T. (2004): Pharmacokinetics, pharmacodynamics, and safety of cinacalcet hydrochloride in hemodialysis patients at doses up to 200 mg once daily. Am. J. Kidney Dis. 44(6), 1070\u20131076. 10.1053\/j.ajkd.2004.08.029https:\/\/doi.org\/10.1053\/j.ajkd.2004.08.029"},{"issue":"2","key":"B19","series-title":"J. Vet. Emerg. Crit. Care","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/vec.12253","article-title":"Magnesium physiology and clinical therapy in veterinary critical care","volume":"25","author":"Humphrey, S.","year":"2015","unstructured":"Humphrey, S., Kirby, R., Rudloff, E. (2015): Magnesium physiology and clinical therapy in veterinary critical care. J. Vet. Emerg. Crit. Care 25(2), 210\u2013225. 10.1111\/vec.12253https:\/\/doi.org\/10.1111\/vec.12253"},{"issue":"5","key":"B20","series-title":"Eur. J. Endocrinol.","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1530\/EJE-14-0877","article-title":"Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery","volume":"172","author":"Khan, A.","year":"2015","unstructured":"Khan, A., Bilezikian, J., Bone, H., Gurevich, A., Lakatos, P., Misiorowski, W., et\u00a0al. (2015): Cinacalcet normalizes serum calcium in a double-blind randomized, placebo-controlled study in patients with primary hyperparathyroidism with contraindications to surgery. Eur. J. Endocrinol. 172(5), 527\u2013535. 10.1530\/EJE-14-0877https:\/\/doi.org\/10.1530\/EJE-14-0877"},{"key":"B21","series-title":"Canine and Feline Nephrology and Urology","first-page":"416","article-title":"Canine and feline hypercalcemic nephropathy","author":"Krueger, J. M.","year":"1995","unstructured":"Krueger, J. M. and Osborne, C. A. (1995): Canine and feline hypercalcemic nephropathy. In: Osborne, C. A. and Finco, D. R. (eds), Canine and Feline Nephrology and Urology, Williams & Wilkins, Philadelphia, pp. 416\u2013440."},{"issue":"6","key":"B22","series-title":"Vet. Clin. North Am. Small Anim. Pract.","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/s0195-5616(96)50135-x","article-title":"Hypercalcemia and renal failure. Etiology, pathophysiology, diagnosis, and treatment","volume":"26","author":"Kruger, J. M.","year":"1996","unstructured":"Kruger, J. M., Osborne, C. A., Nachreiner, R. F. and Refsal, K. R. (1996): Hypercalcemia and renal failure. Etiology, pathophysiology, diagnosis, and treatment. Vet. Clin. North Am. Small Anim. Pract. 26(6), 1417\u20131445. 10.1016\/s0195-5616(96)50135-xhttps:\/\/doi.org\/10.1016\/s0195-5616(96)50135-x"},{"issue":"4","key":"B23","series-title":"Arq. Bras. Med. Vet. Zootec.","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1590\/S0102-09352006000400006","article-title":"Serum concentration of intact parathyroid hormone in dogs with chronic renal failure","volume":"58","author":"Lazaretti, P.","year":"2006","unstructured":"Lazaretti, P., Kogika, M. M., Hagiwara, M. K., Lustoza, M. D. and Mirandola, R. M. S. (2006): Serum concentration of intact parathyroid hormone in dogs with chronic renal failure. Arq. Bras. Med. Vet. Zootec. 58(4), 489\u2013494. 10.1590\/S0102-09352006000400006https:\/\/doi.org\/10.1590\/S0102-09352006000400006 Lazaretti P, Kogika MM, Hagiwara MK, Lustoza MD, Mirandola RMS."},{"issue":"3","key":"B24","series-title":"J. Am. Soc. Nephrol.","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1681\/ASN.2004060512","article-title":"Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study","volume":"16","author":"Lindberg, J. S.","year":"2005","unstructured":"Lindberg, J. S., Culleton, B., Wong, G., Borah, M. F., Clark, R. V., Shapiro, W. B. et\u00a0al. (2005): Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study. J. Am. Soc. Nephrol. 16(3), 800\u2013807. 10.1681\/ASN.2004060512https:\/\/doi.org\/10.1681\/ASN.2004060512"},{"key":"B25","series-title":"J. Vet. Intern. Med.","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/j.1939-1676.2009.0288.x","article-title":"Ionized hypercalcemia in dogs: a retrospective study of 109 cases (1998\u20132003)","volume":"23","author":"Messinger, J. S.","year":"2009","unstructured":"Messinger, J. S., Windham, W. R. and Ward, C. R. (2009): Ionized hypercalcemia in dogs: a retrospective study of 109 cases (1998\u20132003). J. Vet. Intern. Med. 23, 514\u2013519. 10.1111\/j.1939-1676.2009.0288.xhttps:\/\/doi.org\/10.1111\/j.1939-1676.2009.0288.x"},{"issue":"1","key":"B26","series-title":"Adv. Chronic Kidney Dis.","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.ackd.2006.10.005","article-title":"Chronic kidney disease\u2013mineral-bone disorder: a new paradigm","volume":"14","author":"Moe, S. M.","year":"2007","unstructured":"Moe, S. M., Dr\u00fceke, T., Lameire, N. and Eknoyan, G. (2007): Chronic kidney disease\u2013mineral-bone disorder: a new paradigm. Adv. Chronic Kidney Dis. 14(1), 3\u201312. 10.1053\/j.ackd.2006.10.005https:\/\/doi.org\/10.1053\/j.ackd.2006.10.005"},{"issue":"2","key":"B27","series-title":"J. Pharmacol. Exp. Ther.","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1124\/jpet.103.057273","article-title":"Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl","volume":"308","author":"Nemeth, E. F.","year":"2004","unstructured":"Nemeth, E. F., Heaton, W. H., Miller, M., Fox, J., Balandrin, M. F., Van Wagenen, B. C., et\u00a0al. (2004): Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J. Pharmacol. Exp. Ther. 308(2), 627\u2013635. 10.1124\/jpet.103.057273https:\/\/doi.org\/10.1124\/jpet.103.057273"},{"key":"B28","series-title":"Front. Med. (Lausanne).","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.769329","article-title":"Glomerular filtration in the aging population","volume":"9","author":"Noronha, I. L.","year":"2022","unstructured":"Noronha, I. L., Santa-Catharina, G. P., Andrade, L., Coelho, V. A., Jacob-Filho, W. and Elias, R. M. (2022): Glomerular filtration in the aging population. Front. Med. (Lausanne). 9, 769329. 10.3389\/fmed.2022.769329https:\/\/doi.org\/10.3389\/fmed.2022.769329"},{"issue":"5","key":"B29","series-title":"J. Feline Med. Surg.","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1177\/1098612X15581134","article-title":"Feline hyperparathyroidism: pathophysiology, diagnosis and treatment of primary and secondary disease","volume":"17","author":"Parker, V. J.","year":"2015","unstructured":"Parker, V. J., Gilor, C. and Chew, D. J. (2015): Feline hyperparathyroidism: pathophysiology, diagnosis and treatment of primary and secondary disease. J. Feline Med. Surg. 17(5), 427\u2013439. 10.1177\/1098612X15581134https:\/\/doi.org\/10.1177\/1098612X15581134"},{"key":"B30","series-title":"Cunningham\u2019s Textbook of Veterinary Physiology","first-page":"378","article-title":"The endocrine system","author":"Petroff, B. K.","year":"2020","unstructured":"Petroff, B. K. and Greco, D. S. (2020): The endocrine system. In: Klein, B. G. (ed), Cunningham\u2019s Textbook of Veterinary Physiology, 6th edn. Elsevier, Missouri, pp. 378\u2013427."},{"key":"B31","series-title":"Mol. Metab.","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101480","article-title":"Parathyroid hormone (PTH) regulation of metabolic homeostasis: an old dog teaches us new tricks","volume":"60","author":"Rendina-Ruedy, E.","year":"2022","unstructured":"Rendina-Ruedy, E. and Rosen, C. J. (2022): Parathyroid hormone (PTH) regulation of metabolic homeostasis: an old dog teaches us new tricks. Mol. Metab. 60, 101480. 10.1016\/j.molmet.2022.101480https:\/\/doi.org\/10.1016\/j.molmet.2022.101480"},{"key":"B32","series-title":"Int. J. Nephrol. Renovasc. Dis.","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2147\/IJNRD.S216673","article-title":"The importance of tubular function in chronic kidney disease","volume":"12","author":"Risso, M. A.","year":"2019","unstructured":"Risso, M. A., Sallustio, S., Sueiro, V., Bertoni, V., Gonzalez-Torres, H. and Musso, C. G. (2019): The importance of tubular function in chronic kidney disease. Int. J. Nephrol. Renovasc. Dis. 12, 257\u2013262. 10.2147\/IJNRD.S216673https:\/\/doi.org\/10.2147\/IJNRD.S216673"},{"key":"B33","series-title":"Clinical Endocrinology of Companion Animals","first-page":"356","article-title":"Hypercalcemia in dogs","author":"Schenck, P. A.","year":"2013","unstructured":"Schenck, P. A. and Chew, D. (2013): Hypercalcemia in dogs. In: Rand, J., Behrend, E., Gunn-Moore, D. and Campbell-Ward, M. (eds), Clinical Endocrinology of Companion Animals, 1st edn. Wiley-Blackwell, pp. 356\u2013372."},{"issue":"5","key":"B34","series-title":"Nat. Rev. Nephrol.","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nrneph.2014.49","article-title":"Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease","volume":"10","author":"Scialla, J. J.","year":"2014","unstructured":"Scialla, J. J. and Wolf, M. (2014): Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease. Nat. Rev. Nephrol. 10(5), 268\u2013278. 10.1038\/nrneph.2014.49https:\/\/doi.org\/10.1038\/nrneph.2014.49"},{"issue":"1","key":"B35","series-title":"Ren. Fail.","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1080\/0886022X.2018.1562356","article-title":"The effectiveness of cinacalcet: a randomized, open-label study in chronic hemodialysis patients with severe secondary hyperparathyroidism","volume":"41","author":"Susantitaphong, P.","year":"2019","unstructured":"Susantitaphong, P., Vadcharavivad, S., Susomboon, T., Singhan, W., Dumrongpisutikul, N., Jakchairoongruang, K., et\u00a0al. (2019): The effectiveness of cinacalcet: a randomized, open-label study in chronic hemodialysis patients with severe secondary hyperparathyroidism. Ren. Fail. 41(1), 326\u2013333. 10.1080\/0886022X.2018.1562356https:\/\/doi.org\/10.1080\/0886022X.2018.1562356"},{"issue":"2","key":"B36","series-title":"J. Vet. Intern. Med.","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1939-1676.1989.tb03084.x","article-title":"Intact parathyroid hormone assay and total calcium concentration in the diagnosis of disorders of calcium metabolism in dogs","volume":"3","author":"Torrance, A. G.","year":"1989","unstructured":"Torrance, A. G. and Nachreiner, R. (1989): Intact parathyroid hormone assay and total calcium concentration in the diagnosis of disorders of calcium metabolism in dogs. J. Vet. Intern. Med. 3(2), 86\u201389. 10.1111\/j.1939-1676.1989.tb03084.xhttps:\/\/doi.org\/10.1111\/j.1939-1676.1989.tb03084.x"},{"issue":"12","key":"B37","series-title":"J. Am. Soc. Nephrol.","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1681\/ASN.2007121320","article-title":"Cinacalcet reduces the set point of the PTH-calcium curve","volume":"19","author":"Valle, C.","year":"2008","unstructured":"Valle, C., Rodriguez, M., Santamar\u00eda, R., Almaden, Y., Rodriguez, M. E., Ca\u00f1adillas, S., Martin-Malo, A. and Aljama, P. (2008): Cinacalcet reduces the set point of the PTH-calcium curve. J. Am. Soc. Nephrol. 19(12), 2430\u20132436. 10.1681\/ASN.2007121320https:\/\/doi.org\/10.1681\/ASN.2007121320"},{"issue":"6","key":"B38","series-title":"Expert Opin. Pharmacother.","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1517\/14656566.2013.777041","article-title":"Cinacalcet hydrochloride for the treatment of hyperparathyroidism","volume":"14","author":"Verheyen, N.","year":"2013","unstructured":"Verheyen, N., Pilz, S., Eller, K., Kienreich, K., Fahrleitner-Pammer, A., Pieske, B., Ritz, E. and Tomaschitz, A. (2013): Cinacalcet hydrochloride for the treatment of hyperparathyroidism. Expert Opin. Pharmacother. 14(6), 793\u2013806. 10.1517\/14656566.2013.777041https:\/\/doi.org\/10.1517\/14656566.2013.777041"},{"issue":"5","key":"B39","series-title":"Kidney Int","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1111\/j.1523-1755.2000.00370.x","article-title":"Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism","volume":"58","author":"Yano, S.","year":"2000","unstructured":"Yano, S., Sugimoto, T., Tsukamoto, T., Chihara, K., Kobayashi, A., Kitazawa, S., et\u00a0al. (2000): Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism. Kidney Int. 58(5), 1980\u20131986. 10.1111\/j.1523-1755.2000.00370.xhttps:\/\/doi.org\/10.1111\/j.1523-1755.2000.00370.x"},{"issue":"12","key":"B40","series-title":"Animals (Basel)","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.3390\/ani10122411","article-title":"Analytical and clinical validation of a new immunoenzymatic method for the measurement of canine parathyroid hormone","volume":"10","author":"Zambarbieri, J.","year":"2020","unstructured":"Zambarbieri, J., Tagliasacchi, F., Moretti, P., Giordano, A. and Scarpa, P. (2020): Analytical and clinical validation of a new immunoenzymatic method for the measurement of canine parathyroid hormone. Animals (Basel). 10(12), 2411. 10.3390\/ani10122411https:\/\/doi.org\/10.3390\/ani10122411"}],"container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/73\/4\/article-p243.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/004\/73\/4\/article-p243.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/004\/73\/4\/article-p243.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:31:10Z","timestamp":1763991070000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/73\/4\/article-p243.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":41,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1556\/004.2025.01177","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"type":"print","value":"0236-6290"},{"type":"electronic","value":"1588-2705"}],"subject":[],"published":{"date-parts":[[2025,11,24]]}}}