{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:22:10Z","timestamp":1783981330662,"version":"3.55.0"},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVet"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The low dose dexamethasone stimulation test (LDDST) is routinely used in canine medicine but in the few cases in guinea pigs diagnosed with hypercortisolism, the adrenocorticotropic hormone (ACTH) stimulation test was used. The objective of the authors was to conduct a pilot study and find out if the standard test used in dogs can be used in this species.<\/jats:p><jats:p>A 4-year-old intact female hairless guinea pig showed bilaterally enlarged adrenal glands and high cortisol levels. Urine was collected and, after initial saliva sample collection, 0.01\u2009mg*kg<jats:sup>\u22121<\/jats:sup> dexamethasone was administered. Saliva was collected with a 1\u2009mL syringe to determine cortisol levels upon 2, 4 and 8\u2009h after dexamethasone application.<\/jats:p><jats:p>The urine cortisol:creatinine ratio was above 465.4*10<jats:sup>\u22126<\/jats:sup>. Before applying dexamethasone, the cortisol level was 171\u2009nmol*L<jats:sup>\u22121<\/jats:sup>. 2\u2009h after initial application, it was 79\u2009nmol*L<jats:sup>\u22121<\/jats:sup>, at 4\u2009h it was 70\u2009nmol*L<jats:sup>\u22121<\/jats:sup>, and at 8\u2009h it rose to 1,280\u2009nmol*L<jats:sup>\u22121<\/jats:sup>.<\/jats:p><jats:p>The LDDST used in canine medicine to diagnose hypercortisolism can be adapted to guinea pigs and yields results to diagnose Cushing's syndrome in this species. As dexamethasone is more accessible, cheaper and more sensitive than the ACTH stimulation test, it should be a preferred choice from all aspects.<\/jats:p>","DOI":"10.1556\/004.2025.01191","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T09:43:39Z","timestamp":1757324619000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis of Cushing's syndrome in a guinea pig (Cavia porcellus) applying the modified version of the low-dose dexamethasone-suppression test used in canines"],"prefix":"10.1556","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-1228","authenticated-orcid":true,"given":"Anna Linda","family":"N\u00f3gr\u00e1di","sequence":"first","affiliation":[{"name":"Department of Exotic Animal-, Wildlife-, Fish- and Honeybee Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1risz","family":"Ziszisz","sequence":"additional","affiliation":[{"name":"Department of Exotic Animal-, Wildlife-, Fish- and Honeybee Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fcnde","family":"Kanyorszky","sequence":"additional","affiliation":[{"name":"Department of Exotic Animal-, Wildlife-, Fish- and Honeybee Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antal","family":"Papp","sequence":"additional","affiliation":[{"name":"Department of Exotic Animal-, Wildlife-, Fish- and Honeybee Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Exotic Animal-, Wildlife-, Fish- and Honeybee Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Cope","sequence":"additional","affiliation":[{"name":"Newmarket Vets4Pets, Inside Pets at Home, Studland Retail Park, Fordham Road, Newmarket, Suffolk, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"M\u00e1rialigeti","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Oncology, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Vajdovich","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Oncology, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Hetyey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra","family":"Csat\u00e1ri","sequence":"additional","affiliation":[{"name":"Department of Exotic Animal-, Wildlife-, Fish- and Honeybee Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Department of Surgery and Ophthalmology, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"V\u00edzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n Street 2, 1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"J.\u00a0Physiol.","first-page":"305","article-title":"Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function and blood pressure in mature male guinea pigs","volume":"558","author":"Banjanin, S.","year":"2004","unstructured":"Banjanin, S., Kapoor, A. and Matthews, S. 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