{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:57Z","timestamp":1789570977040,"version":"build-2803163510"},"reference-count":20,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVET"],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mammary gland tumours are the most frequently diagnosed neoplasms in female dogs, involving either the mammary gland parenchyma or the mammary papilla. This is a case report of a malignant adenomyoepithelioma with papillary arrangement in the mammary papilla of a 13-year-old female Lhasa Apso, highlighting the histopathological and immunohistochemical characteristics of the tumour. Grossly, the sample consisted of a exophytic, soft to firm nodule measuring 1.0 \u00d7 1.0\u2009cm. On the cut surface, the sample presented an irregular pattern and a cystic cavity. The cut surface of the sentinel lymph node showed a solid and heterogeneous aspect. Histologically, the mammary gland presented a neoplastic proliferation of epithelial and myoepithelial cells in a mostly papillary pattern. Myoepithelial cells exhibited elongated, manly vacuolated cytoplasm, with indistinct boundaries, moderate anisocytosis, anisokaryosis and moderate cellular and nuclear pleomorphism, with seven mitotic figures per 10\u00a0high-power fields (i.e., 2.37 mm\n                    <jats:sup>2<\/jats:sup>\n                    ). The lymph node presented follicular hyperplasia. Immunohistochemical analysis of the primary tumour revealed neoplastic cells positive for pan-cytokeratin and\u00a0p63, presented a Ki-67 index of 20% and were negative (score 0) for cyclooxygenase-2. Based on histomorphological and immunophenotypic findings, the mammary tumour was diagnosed as a malignant adenomyoepithelioma with a papillary pattern.\n                  <\/jats:p>","DOI":"10.1556\/004.2026.01285","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:26:27Z","timestamp":1788171987000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Malignant adenomyoepithelioma with papillary arrangement in the mammary papilla of a dog: Case report"],"prefix":"10.1556","volume":"74","author":[{"given":"Artur","family":"Alves Dariva","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Medeiros Costa Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Yumi","family":"Ribeiro Nakagaki","sequence":"additional","affiliation":[{"name":"Celulavet - Centro de Diagn\u00f3stico Veterin\u00e1rio, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-6743","authenticated-orcid":true,"given":"Geovanni","family":"Dantas Cassali","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Breast J.","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/tbj.12390","article-title":"Malignant adenomyoepithelioma of the breast: a review","volume":"21","author":"Ahmadi, N.","year":"2015","unstructured":"Ahmadi, N., Negahban, S., Aledavood, A., Daneshbod, K. and Daneshbod, Y. 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