{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:57Z","timestamp":1789570977055,"version":"build-2803163510"},"reference-count":44,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["AVET"],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Among dogs with hyperadrenocorticism (HAC), thrombocytosis is frequently reported and is considered to be associated with a hypercoagulable state. Substantial and easily accessible haematological evidence such as platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) indicating hypercoagulability may serve as a basis for considering therapeutic management. This study was performed on 22 dogs diagnosed with uncomplicated pituitary-dependent hyperadrenocorticism (PDH). Twelve dogs were assigned to the control group by computer-based randomisations. A series of standard clinical procedures in all dogs, including clinical examination, blood analyses, urinalysis and abdominal ultrasonography were performed. Platelet-related indices such as PLT, PCT, MPV and PDW were also evaluated at the time of admission in all dogs. Dogs were excluded if they had a secondary disease or hypertension (\u2265160\u2009mmHg). Although no statistical significance was present, PLT, PCT and PDW were higher in PDH dogs compared to healthy controls. In addition, MPV was lower in PDH dogs (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). In conclusion, exhausted bone marrow activity associated with the chronicity of HAC may demonstrate lower MPV values in dogs with PDH. Further studies evaluating the relationship between platelet parameters obtained by whole blood samples and PDH dogs are needed.\n                  <\/jats:p>","DOI":"10.1556\/004.2026.01293","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:31:37Z","timestamp":1788175897000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of platelet parameters in dogs with\u00a0uncomplicated pituitary-dependent hyperadrenocorticism"],"prefix":"10.1556","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-035X","authenticated-orcid":true,"given":"Ekrem","family":"\u00c7a\u011fatay \u00c7olako\u011flu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Ankara University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Sevi\u0307m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Faculty of Veterinary Medicine, Veterinary Teaching Hospital, Ankara University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015einasi","family":"Borgahan Deni\u0307z","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine, Graduate School of Health Science, Veterinary Teaching Hospital, Ankara University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"J. 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