{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:31:57Z","timestamp":1785353517471,"version":"3.55.0"},"reference-count":42,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2020,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some studies suggested an association between <jats:italic>Helicobacter pylori<\/jats:italic> infection and iron-deficiency anemia, however, the link between weight loss and the infection in childhood remains non-established. In a retrospective cohort study, we compared <jats:italic>H. pylori<\/jats:italic> positivity rates of Bulgarian children without or with anemia (47 children in each group) or weight loss (45 children in each group) and both conditions (17 children in each group). <jats:italic>H. pylori<\/jats:italic> infection was associated with the presence of anemia (in 76.6% of the anemic vs. 21.3% of the non-anemic patients, <jats:italic>P<\/jats:italic> &lt; 0.0001) and weight loss (in 82.2% of the patients vs. 17.8% of the control children, <jats:italic>P<\/jats:italic> &lt; 0.0001). All 17 patients with both conditions were <jats:italic>H. pylori<\/jats:italic> positive. Relative risk of anemia, weight loss and both conditions was 3.6 (95% CI, 2.0\u20136.4), 4.6 (95% CI, 2.4\u20138.8) and 5.7 (95% CI, 2.0\u201315.8), respectively, in the children with <jats:italic>H. pylori<\/jats:italic> infection. In conclusion, <jats:italic>H. pylori<\/jats:italic> infection was significantly associated with iron-deficiency anemia or\/and weight loss in Bulgarian pediatric patients. Therefore, diagnostics and treatment of the infection as well as a proper control of the eradication success can be beneficial and thus, can be recommended for children with those conditions.<\/jats:p>","DOI":"10.1556\/030.2020.01158","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:07:07Z","timestamp":1607137627000},"page":"239-242","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":7,"title":["Helicobacter pylori infection is associated with anemia, weight loss or both conditions among Bulgarian children"],"prefix":"10.1556","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-0873","authenticated-orcid":true,"given":"Lyudmila","family":"Boyanova","sequence":"first","affiliation":[{"name":"1Department of Medical Microbiology, Medical University of Sofia, 2 Zdrave str., 1431, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petyo","family":"Hadzhiyski","sequence":"additional","affiliation":[{"name":"2Specialized Hospital for Active Pediatric Treatment, Medical University of Sofia, \u201cAcad. Ivan Evstatiev Geshov\u201d Blvd, 1606, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref181","doi-asserted-by":"crossref","first-page":"12809","DOI":"10.3748\/wjg.v20.i36.12809","article-title":"Role of Helicobacter pylori infection on nutrition and metabolism","volume":"20","author":"Franceschi","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/apa.13724","article-title":"Helicobacter pylori serology testing is a useful diagnostic screening tool for symptomatic inner city children","volume":"106","author":"Raj","year":"2017","journal-title":"Acta Paediatr"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.diagmicrobio.2009.04.005","article-title":"High prevalence of virulent Helicobacter pylori strains in symptomatic Bulgarian patients","volume":"64","author":"Boyanova","year":"2009","journal-title":"Diagn 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