{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:50:33Z","timestamp":1792000233324,"version":"4.4.0"},"reference-count":68,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2020,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over a 4-year study period from 2015 to 2018, altogether 183 isolates of bacterial meningitis were collected from 12 hospitals covering the entire Moroccan territory. <jats:italic>Neisseria meningitidis<\/jats:italic> represented 58.5%, <jats:italic>Streptococcus pneumoniae<\/jats:italic> 35.5%, and <jats:italic>Haemophilus influenzae type b<\/jats:italic> 6%. <jats:italic>H. influenzae type b<\/jats:italic> mainly affected 5-year-olds and unvaccinated adults. <jats:italic>N. meningitidis serogroup B<\/jats:italic> represented 90.7% followed by <jats:italic>serogroup W135<\/jats:italic> with 6.5%. Decreased susceptibility to penicillin G (DSPG) for all isolates accounted for 15.7%, with 11.6% being resistant to penicillin G (PG) and 4.1% decreased susceptibility. Cumulative results of all strains showed 2.7% decreased susceptibility to amoxicillin and 3.3% resistant, 2.2% of isolates were resistant to third-generation cephalosporin and 2.2% were decreased susceptible, 5.5% were resistant to chloramphenicol and 2.7% were resistant to rifampin. The frequency of DSPG observed in our study is more common in <jats:italic>S. pneumoniae<\/jats:italic> than in <jats:italic>N. meningitidis<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0.05). These isolates have been found to be highly susceptible to antibiotics used for treatment and prophylaxis chemotherapy and the observed resistance remains rare. The impact of introduction of conjugate vaccines against <jats:italic>H. influenzae type b<\/jats:italic> and <jats:italic>S. pneumoniae<\/jats:italic> (PCVs) is an advantage in reducing meningitis cases due to these two species.<\/jats:p>","DOI":"10.1556\/030.2020.01222","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T03:02:55Z","timestamp":1606532575000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":9,"title":["Epidemiology and antibiotic resistance profile of bacterial meningitis in Morocco from 2015 to 2018"],"prefix":"10.1556","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-0403","authenticated-orcid":true,"given":"Youssef","family":"Ikken","sequence":"first","affiliation":[{"name":"1Biosafety Level 3 and Research Laboratory, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10 000, Morocco"},{"name":"2Laboratory of Medical Bacteriology, National Institute of Hygiene in Rabat, 27, Avenue Ibn Batouta, B.P. 769, Rabat 10 000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9da","family":"Charof","sequence":"additional","affiliation":[{"name":"2Laboratory of Medical Bacteriology, National Institute of Hygiene in Rabat, 27, Avenue Ibn Batouta, B.P. 769, Rabat 10 000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Benaouda","sequence":"additional","affiliation":[{"name":"3Laboratory of Microbiology, Cheick-Zaid University Hospital, University Internationale Abulcasis of Sciences and Health in Rabat, B.P. 6533, Avenue Allal El Fassi, Madinat Al Irfane, Rabat 10 000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-3784","authenticated-orcid":true,"given":"Farida","family":"Hilali","sequence":"additional","affiliation":[{"name":"1Biosafety Level 3 and Research Laboratory, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10 000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-7847","authenticated-orcid":true,"given":"Sanae","family":"Akkaoui","sequence":"additional","affiliation":[{"name":"4Research Laboratory in Oral Biology and Biotechnology, Faculty of Dental Medicine, Mohammed V University in Rabat, Rabat 10 000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Elouennass","sequence":"additional","affiliation":[{"name":"5Laboratory of Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, 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