{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:22:54Z","timestamp":1740140574943,"version":"3.37.3"},"reference-count":76,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"crossref","award":["98-1-4-14452"],"award-info":[{"award-number":["98-1-4-14452"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2020,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting penicillin binding protein (PBP2a).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, 228 clinical MRSA isolates were collected from four cities of Iran and their susceptibility to ceftaroline was evaluated by E-test and the disk diffusion method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed a high susceptibility rate (97.3%) to ceftaroline in MRSA strains from Iran. Six isolates were found to be ceftaroline non-susceptible (CPT-NS) with Minimum inhibitory concentration (MIC) \u22652 \u00b5g\/mL. All CPT-NS isolates were isolated from blood and tracheal aspirate and belonged to SCC<jats:italic>mec<\/jats:italic> type III as well as <jats:italic>agr<\/jats:italic> type I and were all susceptible to vancomycin. Out of six isolates, three, two and one belonged to <jats:italic>spa<\/jats:italic> type t030, t4864, and t969, respectively. Vancomycin, quinupristin\/dalfopristin, linezolid, chloramphenicol, and tigecycline were the most active agents against CPT-NS isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to the broad-spectrum activity and low toxicity of ceftaroline as well as the increased rate of vancomycin resistance among MRSA strains in recent years, ceftaroline can be considered as a novel approach to treat MRSA-induced infections.<\/jats:p><\/jats:sec>","DOI":"10.1556\/030.2020.01273","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:07:07Z","timestamp":1607137627000},"page":"228-233","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran"],"prefix":"10.1556","volume":"67","author":[{"given":"Amin","family":"Khoshbayan","sequence":"first","affiliation":[{"name":"1Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aref","family":"Shariati","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsanollah","family":"Ghaznavi-Rad","sequence":"additional","affiliation":[{"name":"2Department of Medical Laboratory Sciences, Arak School of Paramedicine, Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"van Belkum","sequence":"additional","affiliation":[{"name":"3Open Innovation & Partnerships, Route de Port Michaud, 38390, La Balme Les Grottes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-3906","authenticated-orcid":true,"given":"Davood","family":"Darban-Sarokhalil","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref291","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.burns.2013.02.005","article-title":"The prevalence of methicillin resistant Staphylococcus aureus (MRSA) isolates with high-level mupirocin resistance from patients and personnel in a burn center","volume":"39","author":"Abbasi-Montazeri","year":"2013","journal-title":"Burns"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijantimicag.2019.06.025","article-title":"Off-label use of ceftaroline fosamil: a systematic review","volume":"54","author":"Pani","year":"2019","journal-title":"Int J Antimicrob Agents"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1469-0691.2007.01720.x","article-title":"A new multiplex PCR for easy screening of methicillin\u2010resistant Staphylococcus aureus SCCmec types I\u2013V","volume":"13","author":"Boye","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1128\/AAC.01787-10","article-title":"In vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in Canadian hospitals in 2009","volume":"55","author":"Karlowsky","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"volume-title":"Ceftaroline for severe methicillin-resistant Staphylococcus aureus infections: a systematic review. 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