{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:11:47Z","timestamp":1792523507642,"version":"4.5.0"},"reference-count":56,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2021,6,21]]},"abstract":"Abstract<\/jats:title>The present study evaluated the carbapenem resistance mechanisms of Klebsiella pneumoniae<\/jats:italic> strains isolated in two Greek tertiary teaching hospitals and their susceptibility to currently used and novel antimicrobial agents.<\/jats:p>Forty-seven carbapenem resistant K. pneumoniae<\/jats:italic> strains were collected in G. Papanikolaou and Ippokrateio hospital of Thessaloniki between 2016 and 2018. Strain identification and antimicrobial susceptibility was conducted by Vitek 2 system (Biom\u00e9rieux France). Susceptibility against new antimicrobial agents was examined by disk diffusion method. Polymerase chain reaction (PCR) was used to detect bla<\/jats:italic>KPC<\/jats:sub>, bla<\/jats:italic>VIM<\/jats:sub>, bla<\/jats:italic>NDM<\/jats:sub> and bla<\/jats:italic>OXA-48<\/jats:sub> genes.<\/jats:p>The meropenem\u2013EDTA and meropenem\u2013boronic acid synergy test performed on the 24 K. pneumoniae<\/jats:italic> strains demonstrated that 8 (33.3%) yielded positive for metallo-beta-lactamases (MBL) and 16 (66.6%) for K. pneumonia<\/jats:italic> carbapenemases (KPC) production. Colistin demonstrated the highest in vitro<\/jats:italic> activity (87.7%) among the 47 K. pneumoniae<\/jats:italic> strains followed by gentamicin (76.5%) and tigecycline (51%). Among new antibiotics ceftazidime\/avibactam showed the highest sensitivity (76.6%) in all strains followed by eravacycline (66.6%). The bla<\/jats:italic>KPC<\/jats:sub> gene was present in 30 strains (63.8%), the bla<\/jats:italic>NDM<\/jats:sub> in 11 (23.4%) and the bla<\/jats:italic>VIM<\/jats:sub> in 6 (12.8%). The bla<\/jats:italic>OXA-48<\/jats:sub> gene was not detected.<\/jats:p>Well established antimicrobial agents such as colistin, gentamicin and tigecycline and novel antibiotics like ceftazidime\/avibactam and eravacycline can be reliable options for the treatment of invasive infections caused by carbapenem-resistant K. pneumoniae<\/jats:italic>.<\/jats:p>","DOI":"10.1556\/030.2021.01364","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:47:12Z","timestamp":1614599232000},"page":"65-72","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Ceftazidime\/avibactam and eravacycline susceptibility of carbapenem-resistant Klebsiella pneumoniae in two Greek tertiary teaching hospitals"],"prefix":"10.1556","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-4546","authenticated-orcid":true,"given":"Maria","family":"Chatzidimitriou","sequence":"first","affiliation":[{"name":"1School of Biomedical Sciences, International Hellenic University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Chatzivasileiou","sequence":"additional","affiliation":[{"name":"2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Sakellariou","sequence":"additional","affiliation":[{"name":"3Medical School, Demokritus University of Thrace, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MariaAnna","family":"Kyriazidi","sequence":"additional","affiliation":[{"name":"2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimoula","family":"Kavvada","sequence":"additional","affiliation":[{"name":"1School of Biomedical Sciences, International Hellenic University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Chatzidimitriou","sequence":"additional","affiliation":[{"name":"2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fani","family":"Chatzopoulou","sequence":"additional","affiliation":[{"name":"2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Meletis","sequence":"additional","affiliation":[{"name":"2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mavridou","sequence":"additional","affiliation":[{"name":"1School of Biomedical Sciences, International Hellenic University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Rousis","sequence":"additional","affiliation":[{"name":"2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Katsifa","sequence":"additional","affiliation":[{"name":"4General Teaching Hospital \u201cG. Papanikolaou\u201d, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Vagdatli","sequence":"additional","affiliation":[{"name":"5General Teaching Hospital \u201cIppokrateio\u201d, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Mitka","sequence":"additional","affiliation":[{"name":"1School of Biomedical Sciences, International Hellenic University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lialiaris","family":"Theodoros","sequence":"additional","affiliation":[{"name":"3Medical School, Demokritus University of Thrace, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref401","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/jac\/dkl481","article-title":"Multiplex PCR for rapid detection of genes encoding acquired 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