{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:01Z","timestamp":1787161561468,"version":"build-2736575974"},"reference-count":144,"publisher":"Akademiai Kiado Zrt.","issue":"1","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The increasingly wide use of next-generation sequencing technologies has revolutionised our knowledge of microbial environments associated with human skin, gastrointestinal tract and blood. The collective set of microorganisms influences metabolic processes, affects immune responses, and so directly or indirectly modulates disease. Rosacea is a skin condition of abnormal inflammation and vascular dysfunction, and its progression is affected by\n                    <jats:italic>Demodex<\/jats:italic>\n                    mites on the skin surface. When looking into the effects influencing development of rosacea, it is not only the skin microbiome change that needs to be considered. Changes in the intestinal microbiome and their circulating metabolites, as well as changes in the blood microbiome also affect the progression of rosacea. Recent research has confirmed the increased presence of bacterial genera like\n                    <jats:italic>Acidaminococcus<\/jats:italic>\n                    and\n                    <jats:italic>Megasphera<\/jats:italic>\n                    in the intestinal microbiome and\n                    <jats:italic>Rheinheimera<\/jats:italic>\n                    and\n                    <jats:italic>Sphingobium<\/jats:italic>\n                    in the blood microbiome of rosacea patients. In this review we discuss our current knowledge of the interactions between the immune system and the skin, gut and blood microbiome, with particular attention to rosacea diagnostic opportunities.\n                  <\/jats:p>","DOI":"10.1556\/030.2021.01366","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T06:47:10Z","timestamp":1614581230000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":21,"title":["Interactions between immune system and the microbiome of skin, blood and gut in pathogenesis of rosacea"],"prefix":"10.1556","volume":"68","author":[{"given":"Marie Isolde","family":"Joura","sequence":"first","affiliation":[{"name":"1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Brunner","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Nemes-Nikod\u00e9m","sequence":"additional","affiliation":[{"name":"2Department of Biochemistry, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-7316","authenticated-orcid":true,"given":"Eszter","family":"Ostorh\u00e1zi","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary"},{"name":"3Department of Medical Microbiology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref1021","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1046\/j.1468-3083.2002.00497.x","article-title":"The link between Helicobacter pylori infection and rosacea","volume":"16","author":"Szlachcic","year":"2002","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref1341","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fcimb.2018.00005","article-title":"Identification and characterization of blood and neutrophil-associated microbiomes in patients with severe acute pancreatitis using next-generation sequencing","volume":"8","author":"Li","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"ref1411","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1099\/ijs.0.65489-0","article-title":"Rheinheimera soli sp. nov., a gammaproteobacterium isolated from soil in Korea","volume":"58","author":"Ryu","year":"2008","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref941","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1365-2133.2011.10746.x","article-title":"Demodex-associated bacterial proteins induce neutrophil activation","volume":"166","author":"O'Reilly","year":"2012","journal-title":"Br J Dermatol"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cgh.2008.02.054","article-title":"Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication","volume":"6","author":"Parodi","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref1351","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jdv.14538","article-title":"Moderate to severe hidradenitis suppurativa patients do not have an altered bacterial composition in peripheral blood compared to healthy controls","volume":"32","author":"Ring","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref1381","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1099\/ijsem.0.000471","article-title":"Taxonomic description and genome sequence of Rheinheimera mesophila sp. nov., isolated from an industrial waste site","volume":"65","author":"Kumar","year":"2015","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/jidsymp.2011.4","article-title":"Rosacea as a disease of cathelicidins and skin innate immunity","volume":"15","author":"Yamasaki","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"ref1041","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1523-5378.2006.00410.x","article-title":"Production of reactive oxygen species in peripheral blood is increased in individuals with Helicobacter pylori infection and decreased after its eradication","volume":"11","author":"Mashimo","year":"2006","journal-title":"Helicobacter"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3389\/fmicb.2017.01829","article-title":"A review on the applications of next generation sequencing technologies as applied to food-related microbiome studies","volume":"8","author":"Cao","year":"2017","journal-title":"Front Microbiol"},{"key":"ref491","first-page":"418","article-title":"Etiopathogenesis of rosacea: a prospective study with a three-year follow-up","volume":"152","author":"Agnoletti","year":"2017","journal-title":"G Ital Dermatol Venereol"},{"key":"ref1141","article-title":"Comparison of the skin microbiota in acne and rosacea","author":"Thompson","year":"2020","journal-title":"Exp Dermatol"},{"key":"ref901","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaad.2003.05.005","article-title":"Temperature regulates bacterial protein production: possible role in 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Microbiol"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41398-018-0107-9","article-title":"Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia","volume":"8","author":"Olde Loohuis","year":"2018","journal-title":"Transl Psychiatry"},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1001\/archderm.134.4.511","article-title":"Helicobacter pylori in rosacea: lack of an association","volume":"134","author":"Jones","year":"1998","journal-title":"Arch Dermatol"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nature04267","article-title":"Control of B-cell responses by Toll-like receptors","volume":"438","author":"Pasare","year":"2005","journal-title":"Nature"},{"key":"ref781","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091562","article-title":"Rosacea: molecular mechanisms and management of a chronic cutaneous inflammatory 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