{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T10:40:16Z","timestamp":1699872016151},"reference-count":78,"publisher":"Akademiai Kiado Zrt.","funder":[{"name":"Research Deputy of Shahid Beheshti University of Medical Sciences, Tehran, Iran","award":["25941"],"award-info":[{"award-number":["25941"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2021,11,22]]},"abstract":"Abstract<\/jats:title>Staphylococcus aureus as<\/jats:italic>an opportunistic bacterial pathogen with intrinsic and acquired resistance to many antibiotics is a worldwide problem. The current study was undertaken to evaluate the resistance pattern, and determine the genetic types of multidrug-resistantS. aureus<\/jats:italic>isolated from wound.<\/jats:p>This cross-sectional study was conducted over the period of two years (from December 2018 to November 2020) at the hospitals affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran. In present study, 75 multidrug-resistantS. aureus<\/jats:italic>isolates collected from wound infections were investigated. Phenotypic resistance was assessed by Kirby\u2013Bauer disk diffusion method. Conventional PCR was performed for the detection of virulence encoding genes. Genotyping of strains was performed based oncoa<\/jats:italic>gene polymorphism using multiplex-PCR assay. SCCmec<\/jats:italic>typing,spa<\/jats:italic>typing and MLST were also used to characterize the genotype of the mupirocin, tigecycline and vancomycin resistant multidrug-resistantS. aureus<\/jats:italic>isolates.<\/jats:p>All 75 multidrug-resistantS. aureus<\/jats:italic>isolates in the study were confirmed as MRSA. Coagulase typing distinguished isolates into five genotypic patterns including III (40%), I (24%), IVb (16%), V (10.7%) and type X (9.3%). Resistance to tigecycline was detected in 4% of MDR-MRSA isolates and all belonged to CC8\/ST239- SCCmec<\/jats:italic>III\/t421 lineage. According to our analysis, one VRSA strain was identified that belonged tocoa<\/jats:italic>type V and CC\/ST22-SCCmec<\/jats:italic>IV\/t790 lineage. Resistance to mupirocin was detected in 9.3% of strains. All 7 mupirocin resistant MDR-MRSA isolates exhibited resistance to mupirocin in high level. Of these, 4 isolates belonged to CC\/ST8-SCCmec<\/jats:italic>IV\/t008 (57.1%), 2 isolates belonged to CC\/ST8-SCCmec<\/jats:italic>IV\/t064 (28.6%) and one isolate to CC\/ST22-SCCmec<\/jats:italic>IV\/t790 (14.3%).<\/jats:p>Altogether, current survey provides a snapshot of the characteristics ofS. aureus<\/jats:italic>strains isolated from patients. Our observations highlighted type III as predominantcoa<\/jats:italic>type among multidrug-resistant MDR strains indicating low heterogeneity of these isolates. Our study also indicates the importance of continuous monitoring of the genotypes of MDR-MRSA isolates to prevent nosocomial outbreaks and the spread of MDR isolates.<\/jats:p>","DOI":"10.1556\/030.2021.01534","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T15:20:18Z","timestamp":1637594418000},"update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of CC8\/ST239- SCCmec III\/t421 tigecycline resistant and CC\/ST22-SCCmec IV\/t790 vancomycin resistant Staphylococcus aureus strains isolated from wound: A two-year multi-center study in Tehran, Iran"],"prefix":"10.1556","member":"425","reference":[{"key":"ref571","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1128\/AAC.00079-15","article-title":"High prevalence of mupirocin resistance in Staphylococcus aureus isolates from a pediatric 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