{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:04:19Z","timestamp":1788444259146,"version":"build-2803163510"},"reference-count":84,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n            <jats:p>For many years, coagulase-negative staphylococci (CoNS) have been considered non-pathogenic bacteria. However, recently, CoNS are becoming more common bacteriological factors isolated from cases of chronic rhinosinusitis in humans. Moreover, most of them represent the multidrug-resistant or\/and methicillin-resistant profile, which significantly increases the therapeutic difficulties. The aim of the study was to characterize profile of resistant coagulase-negative staphylococci isolated from cases of chronic rhinosinusitis in patients treated in a Medical Center in Warsaw in 2015\u20132016.<\/jats:p>\n            <jats:p>The study material was derived from patients with diagnosed chronic rhinosinusitis treated at the MML Medical Center in Warsaw. The material was obtained intraoperatively from maxillary, frontal, and ethmoid sinuses.<\/jats:p>\n            <jats:p>In total, 1,044 strains were isolated from the studied material. Coagulase-negative staphylococci were predominant, with the largest share of <jats:italic>Staphylococcus epidermidis<\/jats:italic>. Isolated CoNS were mainly resistant to macrolide, lincosamide, and tetracycline. Among the <jats:italic>S. epidermidis<\/jats:italic> strains, we also showed 35.6% of MDR and 34.7% of methicillin-resistant strains.<\/jats:p>\n            <jats:p>The same values for other non-<jats:italic>epidermidis<\/jats:italic> species were 31.5% and 18.5%, respectively and the percentage of strains with MAR &gt;0.2 was greater in <jats:italic>S. epidermidis<\/jats:italic> (32.6%) than <jats:italic>S<\/jats:italic>. non-<jats:italic>epidermidis<\/jats:italic> (23.9%). Although the percentage of strains resistant to tigecycline, glycopeptides, rifampicin and oxazolidinones was very small (2.3%, 1.9%, 1.4% and 0.7% respectively), single strains were reported in both groups.<\/jats:p>\n            <jats:p>The study has shown a high proportion of MDR and methicillin-resistant CoNS strains, which indicates a large share of drug-resistant microorganisms in the process of persistence of chronic rhinosinusitis; therefore, isolation of this group of microorganisms from clinical cases using aseptic techniques should not be neglected.<\/jats:p>","DOI":"10.1556\/030.2021.01580","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T13:18:35Z","timestamp":1639401515000},"page":"68-76","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Multidrug resistant coagulase-negative Staphylococcus spp. isolated from cases of chronic rhinosinusitis in humans. Study from Poland"],"prefix":"10.1556","volume":"69","author":[{"given":"Micha\u0142","family":"Michalik","sequence":"first","affiliation":[{"name":"MML Medical Center, Bagno 2, 00-112, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-5291","authenticated-orcid":true,"given":"Aneta","family":"Nowakiewicz","sequence":"additional","affiliation":[{"name":"University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Veterinary Sciences, Sub-Department of Veterinary Microbiology, Akademicka 12, 20-033, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Tro\u015bcia\u0144czyk","sequence":"additional","affiliation":[{"name":"University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Veterinary Sciences, Sub-Department of Veterinary Microbiology, Akademicka 12, 20-033, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Kowalski","sequence":"additional","affiliation":[{"name":"University of Life Sciences, Faculty of Veterinary Medicine, Department of Pharmacology, Toxicology and Environmental Protection, Akademicka 12, 20-033, Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Podbielska-Kubera","sequence":"additional","affiliation":[{"name":"MML Medical Center, Bagno 2, 00-112, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref91","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrmicro2537","article-title":"The skin microbiome","volume":"9","author":"Grice","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13756-020-00714-9","article-title":"The global prevalence of Daptomycin, Tigecycline, 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