{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:55:31Z","timestamp":1778864131021,"version":"3.51.4"},"reference-count":80,"publisher":"Akademiai Kiado Zrt.","funder":[{"name":"The Scientific and Technical Research Council of Turkey","award":["TUB\u0130TAK-113Z054"],"award-info":[{"award-number":["TUB\u0130TAK-113Z054"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n            <jats:p>The study aimed to analyze antibiotic resistance determinants in a carbapenem-resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> by whole-genome sequencing (WGS). <jats:italic>K. pneumoniae<\/jats:italic> was isolated from a urine sample and it was characterized by 16S rDNA sequencing in Turkey. This strain was named as <jats:italic>Kpn<\/jats:italic> Rize-53-TR. Antimicrobial susceptibility testing was performed for seventeen antibiotics by VITEK-2 and the result was confirmed by MIC. The whole genome of isolate was sequenced by Illumina and was analysed by bioinformatic tools for MLST, replicon types, and antimicrobial resistance genes. The whole genome data was submitted to NCBI. The isolate was found to be resistant to all tested \u03b2-lactam antibiotics and the highest MIC values were found for piperacillin, piperacillin\/tazobactam (\u2265128). No resistance to colistin and moderate susceptibility to amikacin and tetracycline was observed. The isolate carried 12 resistance genes belonging to 10 resistance classes; <jats:italic>ere<\/jats:italic>(A), <jats:italic>fosA, oqxB, cml<\/jats:italic>A1, <jats:italic>aac(a)-IIa, bla<\/jats:italic>\n               <jats:sub>KPC-2<\/jats:sub>, <jats:italic>bla<\/jats:italic>\n               <jats:sub>TEM-1A<\/jats:sub>, <jats:italic>bla<\/jats:italic>\n               <jats:sub>SHV-67<\/jats:sub>, <jats:italic>bla<\/jats:italic>\n               <jats:sub>CTX-M-15<\/jats:sub>, <jats:italic>bla<\/jats:italic>\n               <jats:sub>OXA-1-2-9<\/jats:sub>. Mutations were detected in <jats:italic>gyrA<\/jats:italic> (83Y) and <jats:italic>parC<\/jats:italic> (80I) genes. Clonal subtype of the isolate was ST147, and it had wzi420 and wzc38 alleles. Its serotype was O3\/O3a. The <jats:italic>bla<\/jats:italic>\n               <jats:sub>KPC-2<\/jats:sub> was firstly found in both ST147 clonal group in Turkey and in serotype O3\/O3a in the world. By plasmid replicon typing, five plasmids IncFII(K), Col(BS512), IncR, IncFIA(HI1) and IncFIB(pQil) were determined in <jats:italic>Kpn<\/jats:italic> Rize-53-TR and <jats:italic>bla<\/jats:italic>\n               <jats:sub>KPC-2<\/jats:sub> was located on IncFII(K) plasmid. The presence of <jats:italic>bla<\/jats:italic>\n               <jats:sub>KPC-2<\/jats:sub> on the plasmid with other resistance genes accelerates its own spread together with other resistance genes.<\/jats:p>","DOI":"10.1556\/030.2022.01690","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T19:55:22Z","timestamp":1645559722000},"update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics in the whole-genome sequence of Klebsiella pneumoniae ST147 from Turkey"],"prefix":"10.1556","author":[{"given":"Halbay","family":"Turumtay","sequence":"first","affiliation":[{"name":"Karadeniz Technical University, Department of Energy System Engineering, 61830, Trabzon, Turkey"},{"name":"Joint BioEnergy Institute, Feedstocks Division, Emeryville, CA 94608, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushal","family":"Allam","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayt\u00fcl","family":"Sandalli","sequence":"additional","affiliation":[{"name":"Recep Tayyip Erdo\u011fan University, Department of Biology, 53020, Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EM\u0130NE AKY\u00dcZ","family":"Turumtay","sequence":"additional","affiliation":[{"name":"Recep Tayyip Erdo\u011fan University, Department of Chemistry, 53020, Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hacer","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Rize Tea Research and Application Center (\u00c7AYMER), 53100, Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-3687","authenticated-orcid":true,"given":"Cemal","family":"Sandalli","sequence":"additional","affiliation":[{"name":"Recep Tayyip Erdo\u011fan University, Department of Biology, 53020, Rize, Turkey"},{"name":"Firtina Research Group, Fener Mahallesi, VillaKent Konutlar\u0131, 53020 Rize, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref101","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1128\/AAC.00456-06","article-title":"Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate","volume":"50","author":"Chen","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref451","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02244-19","article-title":"Genomic epidemiology of complex, 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