{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:45:02Z","timestamp":1790102702890,"version":"4.0.1"},"reference-count":51,"publisher":"Akademiai Kiado Zrt.","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2022,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n            <jats:p>Infections of the urinary tract have been on the rise globally and these are also worsened by the increasing rate of antibiotic resistance in uropathogens. This study aimed to determine the susceptibility profile of extended spectrum \u03b2-lactamase (ESBL)- producing uropathogens to selected antibiotics and their carriage of ESBL genes. Bacterial uropathogens were obtained from the urine bench of a Microbiology laboratory in a Teaching Hospital in South-West Nigeria. Susceptibility to antibiotics was tested using the disc diffusion method, while detection of ESBL production was done using the double disc synergy test (DDST). Detection of ESBL genes was performed by PCR. A total of 21 ESBL- producing uropathogens were obtained namely: <jats:italic>Klebsiella pneumoniae<\/jats:italic> (11), <jats:italic>Klebsiella oxytoca<\/jats:italic> (6), <jats:italic>Proteus mirabilis<\/jats:italic> (2), <jats:italic>Enterobacter cloacae<\/jats:italic> (1) and <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (1). The resistance to antibiotics in the uropathogens was: imipenem (0%), gentamicin (38.1%), sulfamethoxazole-trimethoprim (52.4%), amoxicillin-clavulanate (61.9%), aztreonam (66.7%), ceftazidime (66.7%), tetracycline (90.5%), cefpodoxime (100%) and cefotaxime (100%). Altogether, 90.5% (19\/21) of the isolates were multidrug resistant (MDR). Of the 21 uropathogens, 61.9% (13\/21) carried <jats:italic>bla<\/jats:italic>\n               <jats:sub>CTX-M,<\/jats:sub> 52.4% (11\/21) carried <jats:italic>bla<\/jats:italic>\n               <jats:sub>TEM<\/jats:sub> while <jats:italic>bla<\/jats:italic>\n               <jats:sub>SHV<\/jats:sub> was detected in 47.6% (10\/21) of the isolates. There was co-carriage of ESBL genes in 12 uropathogens. This study showed a high prevalence of multidrug resistance and a high carriage of ESBL genes in the ESBL- producing isolates obtained over the study period. There is a need for a review of antibiotic options in the treatment of UTI to clamp down on the ever-increasing tide of antibiotic resistance in uropathogens.<\/jats:p>","DOI":"10.1556\/030.2022.01747","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T10:41:19Z","timestamp":1654684879000},"update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["High burden of ESBL- producing Klebsiella spp., Proteus mirabilis, Enterobacter cloacae and Pseudomonas aeruginosa in diagnosed cases of urinary tract infection in a Nigerian Teaching Hospital"],"prefix":"10.1556","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2871-1002","authenticated-orcid":true,"given":"Abimbola Olumide","family":"Adekanmbi","sequence":"first","affiliation":[{"name":"Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"},{"name":"Molecular Biology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-7189","authenticated-orcid":true,"given":"Olabisi Comfort","family":"Akinlabi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Usidamen","sequence":"additional","affiliation":[{"name":"Molecular Biology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"},{"name":"Pathogenic Microbiology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-662X","authenticated-orcid":true,"given":"Adedolapo Victoria","family":"Olaposi","sequence":"additional","affiliation":[{"name":"Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"},{"name":"Molecular Biology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola Boluwatife","family":"Olaniyan","sequence":"additional","affiliation":[{"name":"Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"},{"name":"Molecular Biology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Infect Dis Clin North Am","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.idc.2013.09.003","article-title":"Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden","volume":"28","author":"Foxman \n                     B","year":"2014","unstructured":"Foxman \n                     B\n                  \n               . Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. 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J Med Microbiol \n               2016; 65: 530\u2013537.10.1099\/jmm.0.000247"},{"key":"B3","series-title":"Eur Urol","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.eururo.2008.05.010","article-title":"Surveillance study in Europe and Brazil on clinical aspects and antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy","volume":"54","author":"Naber \n                     KG","year":"2008","unstructured":"Naber \n                     KG\n                  , \n                     Schito \n                     G\n                  , \n                     Botto \n                     H\n                  , \n                     Palou \n                     J\n                  , \n                     Mazzei \n                     T\n                  \n               . Surveillance study in Europe and Brazil on clinical aspects and antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur Urol \n               2008; 54: 1164\u20131178.10.1016\/j.eururo.2008.05.010"},{"key":"B4","series-title":"Genet Mol Res","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.4238\/2011.October.31.5","article-title":"Virulence characteristics and antimicrobial susceptibility of uropathogenic Escherichia coli strains","volume":"10","author":"Oliveira \n                     FA","year":"2011","unstructured":"Oliveira \n                     FA\n                  , \n                     Paludo \n                     KS\n                  , \n                     Arend \n                     LN\n                  , \n                     Farah \n                     SM\n                  , \n                     Pedrosa \n                     FO\n                  , \n                     Souza \n                     EM\n                  , et\u00a0al.\n                \n               Virulence characteristics and antimicrobial susceptibility of uropathogenic Escherichia coli strains. 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Indian J Med Res \n               2004\n               ; \n               120: 553\u2013556."},{"key":"B20","series-title":"Afr J Microbiol Res","first-page":"13","article-title":"Incidence of urinary tract infections (UTI) among children and Adolescents in Ile\u2013Ife, Nigeria","volume":"1","author":"Aiyegoro \n                     OA","year":"2007","unstructured":"Aiyegoro \n                     OA\n                  , \n                     Igbinosa \n                     OO\n                  , \n                     Ogunmwonyi \n                     IN\n                  , \n                     Odjadjare \n                     E\n                  , \n                     Igbinosa \n                     OE\n                  , \n                     Okoh \n                     AI\n                  \n               . Incidence of urinary tract infections (UTI) among children and Adolescents in Ile\u2013Ife, Nigeria. 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Antibiotics susceptibility patterns of urine bacterial isolates in Zaria, Nigeria. 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