{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:09:48Z","timestamp":1747199388207,"version":"3.40.5"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2022,9,16]]},"abstract":"Abstract<\/jats:title>\n Echovirus 9 (E9) has been detected in an increased number of symptomatic patient samples received by\u00a0the National Enterovirus Reference Laboratory in Hungary during 2018 compared to previously reported years.<\/jats:p>\n Formerly identified E9 viruses from different specimen types detected from patients of various ages and showing differing clinical signs were chosen for the detailed analysis of genetic relationships and potential variations within the viral populations. We used next generation sequencing (NGS) analysis of 3,900 nucleotide long amplicons covering the entire capsid coding region of the viral genome without isolation, directly from clinical samples.<\/jats:p>\n Compared to the E9 reference strain, the viruses showed about 79% nucleotide and around 93% amino acid sequence similarity. The four new viral genome sequences had 1-20 nucleotide differences between them also resulting in 6 amino acid variances in the coding region, including 3 in the structural VP1 capsid protein. One virus from a patient with hand, foot, and mouth disease had two amino acid changes in the VP1 capsid protein. An amino acid difference was also detected in the non-structural 2C gene of one virus sequenced from a throat swab sample from a patient with meningitis, compared to the faecal specimen taken two days later. Two amino acid changes, one in the capsid protein, were found between faecal samples of meningitis patients of different ages.<\/jats:p>\n Sequencing the whole capsid genome revealed several nucleotide and amino acid differences between E9 virus strains detected in Hungary in 2018.<\/jats:p>","DOI":"10.1556\/030.2022.01788","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T09:50:38Z","timestamp":1655977838000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Echovirus 9 genetic diversity detected in whole-capsid genome sequences obtained directly from clinical specimens using next generation sequencing"],"prefix":"10.1556","volume":"69","author":[{"given":"Erika","family":"Bujaki","sequence":"first","affiliation":[{"name":"National Public Health Center, Department of Virology, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Farkas","sequence":"additional","affiliation":[{"name":"National Public Health Center, Department of Virology, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-6890","authenticated-orcid":true,"given":"M\u00e1ria","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"National Public Health Center, Department of Virology, Budapest, Hungary"},{"name":"Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Infect Genet Evol","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.meegid.2012.10.016","article-title":"Picornavirus and enterovirus diversity with associated human diseases","volume":"14","author":"Tapparel \n C","year":"2013","unstructured":"Tapparel \n C\n , \n Siegrist \n F\n , \n Petty \n TJ\n , \n Kaiser \n L\n \n . Picornavirus and enterovirus diversity with associated human diseases. Infect Genet Evol \n 2013; 14: 282\u2013293. https:\/\/doi.org\/10.1016\/j.meegid.2012.10.016.10.1016\/j.meegid.2012.10.016"},{"key":"B2","series-title":"Fields virology 2","first-page":"490","article-title":"Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses","author":"Pallansch \n M","year":"2013","unstructured":"Pallansch \n M\n , \n Oberste \n M\n , \n Whitton \n J\n \n . Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: \n \n Knipe \n D\n , \n Howley \n P\n \n , editors. Fields virology 2, 6th ed. \n Lippincott Williams & Wilkins; 2013, pp. 490\u2013530."},{"key":"B3","series-title":"MMWR Surveill Summ","first-page":"1","article-title":"Enterovirus surveillance--United States, 1970-2005","volume":"55","author":"Khetsuriani \n N","year":"2006","unstructured":"Khetsuriani \n N\n , \n Lamonte-Fowlkes \n A\n , \n Oberst \n S\n , \n Pallansch \n MA\n \n . Enterovirus surveillance--United States, 1970-2005. MMWR Surveill Summ \n 2006; 55: 1\u201320. https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/ss5508a1.htm."},{"key":"B4","series-title":"J Clin Virol","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.104205","article-title":"A decade of enterovirus genetic diversity in Belgium","volume":"121","author":"Wollants \n E","year":"2019","unstructured":"Wollants \n E\n , \n Beller \n L\n , \n Beuselinck \n K\n , \n Bloemen \n M\n , \n Lagrou \n K\n , \n Reynders \n M\n , et\u00a0al.\n \n A decade of enterovirus genetic diversity in Belgium. 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Euro Surveill \n 2017; 22(26): 30565. https:\/\/doi.org\/10.2807\/1560-7917.ES.2017.22.26.30565.10.2807\/1560-7917.ES.2017.22.26.30565"},{"key":"B12","series-title":"J Clin Microbiol","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1128\/JCM.02121-16","article-title":"High-Throughput next-generation sequencing of polioviruses","volume":"55","author":"Montmayeur \n AM","year":"2017","unstructured":"Montmayeur \n AM\n , \n Ng \n TFF\n , \n Schmidt \n A\n , \n Zhao \n K\n , \n Magana \n L\n , et\u00a0al.\n \n High-Throughput next-generation sequencing of polioviruses. 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Sci Rep \n 2022; 12: 1\u201310. https:\/\/doi.org\/10.1038\/s41598-022-06309-1."},{"key":"B20","series-title":"J Med Virol","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/1096-9071(200101)63:1<35::AID-JMV1005>3.0.CO;2-Q","article-title":"Homotypic echoviruses share\u00a0aminoterminal VP1 sequence homology applicable for typing","volume":"63","author":"Norder \n H","year":"2001","unstructured":"Norder \n H\n , \n Bjerregaard \n L\n , \n Magnius \n LO\n \n . Homotypic echoviruses share\u00a0aminoterminal VP1 sequence homology applicable for typing. J Med Virol \n 2001; 63: 35\u201344.10.1002\/1096-9071(200101)63:1<35::AID-JMV1005>3.0.CO;2-Q"},{"key":"B21","series-title":"Curr Top Microbiol Immunol","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-642-75602-3_5","article-title":"Antigenic structure of picornaviruses","volume":"161","author":"Minor \n PD","year":"1990","unstructured":"Minor \n PD\n \n . Antigenic structure of picornaviruses. Curr Top Microbiol Immunol \n 1990; 161: 121\u2013154. https:\/\/doi.org\/10.1007\/978-3-642-75602-3_5."},{"key":"B22","series-title":"Structure","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/S0969-2126(01)00201-5","article-title":"The structure of coxsackievirus B3 at 3.5 \u00e5 resolution","volume":"3","author":"Muckelbauer \n JK","year":"1995","unstructured":"Muckelbauer \n JK\n , \n Kremer \n M\n , \n Minor \n I\n , \n Diana \n G\n , \n Dutko \n FJ\n , \n Gorarke \n J\n , et\u00a0al.\n \n The structure of coxsackievirus B3 at 3.5 \u00e5 resolution. Structure \n 1995; 3: 653\u2013667. https:\/\/doi.org\/10.1016\/S0969-2126(01)00201-5.10.1016\/S0969-2126(01)00201-5"},{"key":"B23","series-title":"Structure","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S0969-2126(97)00249-9","article-title":"Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes","volume":"5","author":"Lentz \n KN","year":"1997","unstructured":"Lentz \n KN\n , \n Smith \n AD\n , \n Geisler \n SC\n , \n Cox \n S\n , \n Buontempo \n P\n , \n Skelton \n A\n , et\u00a0al.\n \n Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes. Structure \n 1997; 5: 961\u2013978. https:\/\/doi.org\/10.1016\/s0969-2126(97)00249-9.10.1016\/S0969-2126(97)00249-9"},{"key":"B24","series-title":"J Med Virol","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1002\/jmv.23574","article-title":"A single amino acid substitution in viral VP1 protein alters the lytic potential of clone-derived variants of echovirus 9 DM strain in human pancreatic islets","volume":"85","author":"Paananen \n A","year":"2013","unstructured":"Paananen \n A\n , \n Ylipaasto \n P\n , \n Smura \n T\n , \n Lempinen \n M\n , \n Galama \n J\n , \n Roivainen \n M\n \n . A single amino acid substitution in viral VP1 protein alters the lytic potential of clone-derived variants of echovirus 9 DM strain in human pancreatic islets. 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Proc Soc Exp Biol Med \n 1954; 87: 655\u2013661. https:\/\/doi.org\/10.3181\/00379727-87-21474.10.3181\/00379727-87-21474"},{"key":"B27","series-title":"Virus Genes","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/BF00572953","article-title":"Molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain Barty","volume":"12","author":"Zimmermann \n H","year":"1996","unstructured":"Zimmermann \n H\n , \n Eggers \n HJ\n , \n Nelsen-Salz \n B\n \n . Molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain Barty. Virus Genes \n 1996; 12: 149\u2013154. https:\/\/doi.org\/10.1007\/BF00572953.10.1007\/BF00572953"},{"key":"B28","series-title":"Exp Mol Med","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/emm.1998.15","article-title":"Molecular biological characterization of\u00a0enterovirus variant isolated from patients with aseptic meningitis","volume":"30","author":"Jung \n YT","year":"1998","unstructured":"Jung \n YT\n , \n Kim \n GR\n , \n Paik \n SY\n \n . Molecular biological characterization of\u00a0enterovirus variant isolated from patients with aseptic meningitis. Exp Mol Med \n 1998; 30: 101\u2013107. https:\/\/doi.org\/10.1038\/emm.1998.15.10.1038\/emm.1998.15"},{"key":"B29","series-title":"Microbiol Immunol","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1348-0421.2001.tb01306.x","article-title":"Molecular evolution of human echovirus 9 isolated from patients with aseptic meningitis in northern Kyushu during the summer of 1997","volume":"45","author":"Hara \n K","year":"2001","unstructured":"Hara \n K\n , \n Kashiwagi \n T\n , \n Ohtsu \n Y\n , \n Masunaga \n K\n , \n Akasu-Tsuji \n Y\n , \n Tsumara \n N\n , et\u00a0al.\n \n Molecular evolution of human echovirus 9 isolated from patients with aseptic meningitis in northern Kyushu during the summer of 1997. Microbiol Immunol \n 2001; 45: 717\u2013720. https:\/\/doi.org\/10.1111\/j.1348-0421.2001.tb01306.x.10.1111\/j.1348-0421.2001.tb01306.x"},{"key":"B30","series-title":"Virology","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1006\/viro.1997.8601","article-title":"Cell attachment and mouse virulence of echovirus 9 correlate with an RGD motif in the capsid protein VP1","volume":"233","author":"Zimmermann \n H","year":"1997","unstructured":"Zimmermann \n H\n , \n Eggers \n HJ\n , \n Nelsen-Salz \n B\n \n . Cell attachment and mouse virulence of echovirus 9 correlate with an RGD motif in the capsid protein VP1. 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