{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:26:36Z","timestamp":1791815196305,"version":"4.3.4"},"reference-count":49,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"Abstract<\/jats:title>Infections caused by multidrug resistant (MDR) Pseudomonas aeruginosa<\/jats:italic> isolates in burn patients restrict therapeutic strategies. The current study aimed to analyze antibiotic resistance genes and multilocus sequence typing (MLST) of P. aeruginosa<\/jats:italic> strains isolated from burn patients in Shahid Motahari hospital in Tehran, Iran.<\/jats:p>Altogether 63 P. aeruginosa<\/jats:italic> isolates were characterized in this study. Antibiotic susceptibility testing was performed by disc diffusion method. PCR was performed to determine the frequency of resistance genes. The expression rates of mexB<\/jats:italic>, mexY<\/jats:italic> genes were evaluated by Real-Time PCR. Genotyping of isolates was performed by MLST analysis. All isolates were MDR in this study. The highest resistance was detected against gentamicin, tobramycin, and cefoxitin (100%), while all isolates were susceptible to colistin. Altogether 14 resistance profiles were determined, and profile 1 included more than 50% of the isolates with the highest resistance. In this study bla<\/jats:italic>ampC<\/jats:sub>, bla<\/jats:italic>VIM-2<\/jats:sub>, bla<\/jats:italic>OXA-10<\/jats:sub>, and aac(6\u2032)-Ib<\/jats:italic> resistance genes were detected in all isolates. The expression levels of mexB<\/jats:italic> and mexY<\/jats:italic> genes were upregulated in 66.6 and 88.8% of MDR isolates, respectively. Overexpression of both genes was detected in 55.5% of the isolates.<\/jats:p>MLST analysis revealed five sequence types (STs), including ST235, ST664, ST532, ST2637, and ST230, which showed a significant relationship with antibiotic resistance profiles. The present study indicates an increase in antibiotic resistance against different antibiotic families among P. aeruginosa<\/jats:italic> isolates. We describe the circulation of globally distributed STs among hospitalized patients, and we report ST235 as the most common MDR clone in our study.<\/jats:p>","DOI":"10.1556\/030.2022.01882","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T09:01:19Z","timestamp":1674464479000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of multiresistant Pseudomonas aeruginosa isolates from burn patients in Iran"],"prefix":"10.1556","volume":"70","author":[{"given":"Arash","family":"Abednezhad","sequence":"first","affiliation":[{"name":"Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran Asghari","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Faraji","sequence":"additional","affiliation":[{"name":"Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Derakhshan-Nezhad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-4273","authenticated-orcid":true,"given":"Hajar","family":"Mohammadi Barzelighi","sequence":"additional","affiliation":[{"name":"Biosun Pharmed Company, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"1","key":"B1","series-title":"PLoS One","article-title":"Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization","volume":"9","author":"Neely CJ","year":"2014","unstructured":"Neely CJ, Kartchner LB, Mendoza AE, Linz BM, Frelinger JA, Wolfgang MC, et\u00a0al. 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