{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:28:14Z","timestamp":1790681294868,"version":"4.1.0"},"reference-count":44,"publisher":"Akademiai Kiado Zrt.","issue":"1","funder":[{"DOI":"10.13039\/501100013822","name":"Kurdistan University of Medical Sciences","doi-asserted-by":"crossref","award":["IR.MUK.REC.1396\/186"],"award-info":[{"award-number":["IR.MUK.REC.1396\/186"]}],"id":[{"id":"10.13039\/501100013822","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p xml:lang=\"en\">The aim of this study was to determine the frequency of carbapenem resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> (CRKP) sequence types (STs) in Iran. Samples were collected from three university hospitals in Sanandaj, Iran, from December 2016 to March 2018. Antibiotic susceptibility testing, phenotypic and genotypic detection of carbapenemases were performed. Common <jats:italic>K. pneumoniae<\/jats:italic> capsular types were sought for all isolates. The genetic relatedness of isolates was investigated by multilocus sequence typing (MLST). Plasmids were detected by PCR-based Replicon Typing (PBRT). During the study, 67 <jats:italic>K.\u00a0pneumoniae<\/jats:italic> isolates were identified. Of which, 18 (26.9%) isolates were detected as carbapenem-resistant. The most effective antibacterial agent was tigecycline (97%, 65 isolates) followed by imipenem and ertapenem (73.13%, 49 isolates). PCR showed that 13 isolates (19.4%) had <jats:italic>bla<\/jats:italic><jats:sub>NDM-1<\/jats:sub> gene and 5 (7.5%) harbored <jats:italic>bla<\/jats:italic><jats:sub>OXA-48<\/jats:sub>. Examination of common capsular types showed that 2 isolates had K2 and 2 others had K54. REP-PCR revealed 10 clones and 11 singleton strains. MLST analysis of CRKP found ST15 as the most common type (13 isolates, 72.2%), but other STs were also detected namely, ST19, ST117, ST1390, and ST1594. ColE1 and IncL\/M plasmids were the carriers of <jats:italic>bla<\/jats:italic><jats:sub>NDM-1<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>OXA-48<\/jats:sub>, respectively. The results showed that CRKP spread in our health centers. Our results, therefore, indicate a worrying trend of resistance to carbapenems in <jats:italic>K. pneumoniae<\/jats:italic>.<\/jats:p>","DOI":"10.1556\/030.2023.01945","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T10:44:23Z","timestamp":1673952263000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of NDM-1 and OXA-48 producing carbapenem resistant Klebsiella pneumoniae ST15 in Iran"],"prefix":"10.1556","volume":"70","author":[{"given":"Hedayat Bozorgi","family":"Mohajer","sequence":"first","affiliation":[{"name":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-8694","authenticated-orcid":true,"given":"Himen","family":"Salimizand","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"},{"name":"Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahieh","family":"Gharanizadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afra","family":"Hossainpanahi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid","family":"Ramazanzadeh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"BMC Infect Dis","first-page":"603","article-title":"Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates","volume":"22","author":"Kochan TJ","year":"2022","unstructured":"Kochan TJ, Nozick SH, Medernach RL, Cheung BH, Gatesy SWM, Lebrun-Corbin M, et\u00a0al. 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