{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:27:02Z","timestamp":1779924422159,"version":"3.53.1"},"update-to":[{"DOI":"10.1556\/030.2023.02050","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"record-id":"53235"},{"DOI":"10.1556\/030.2023.02050","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000}}],"reference-count":43,"publisher":"Akademiai Kiado Zrt.","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Due to the rise of bacteria that are resistant to multiple drugs, treating infections in burn wounds has become a worldwide problem. It is important to find new ways to treat these infections. Lipid-based drug delivery systems have emerged as a promising type of carrier for antibiotics as well as antibacterial agents, such as antimicrobial peptides and nucleic acids, for wound infections. To this end, the current study assessed the antibacterial effects and wound healing properties of vancomycin-loaded solid lipid nanoparticles (SLN) against methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA) surgical wound infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      vancomycin-SLN was synthesized by double emulsion solvent evaporation techniques, and then\n                      <jats:italic>in vitro<\/jats:italic>\n                      antibacterial activity was evaluated by well diffusion and broth microdilution methods. A surgical wound was inflicted on 36 male rats; the infection was caused by MRSA, and free vancomycin and vancomycin-SLN were topically applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Particle size, PDI, zeta potential, drug loading, and encapsulation efficiency of the optimum vancomycin-SLN were 350 \u00b1 24\u2009nm, 0.402 \u00b1 0.014, \u221216.3 \u00b1 2.5\u2009mV, 13.9 \u00b1 1.4%, and 92.14 \u00b1 3.1%, respectively.\n                      <jats:italic>In vitro<\/jats:italic>\n                      antibacterial assays showed lower MICs for free vancomycin and killed bacteria more efficiently than vancomycin-SLN. However, the synthesized nanoparticles indicated long-term antibacterial activity against MRSA. Animals that were treated with vancomycin-SLN showed the best wound healing procedure. Treatment of rats with vancomycin-SLN increased re-epithelialization and decreased granulation tissue development, as seen by histological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antibiotic-loaded SLN could not only manage wound infection but also enhance wound healing. Therefore, this kind of treatment should be considered by scientists as an applicable treatment for wounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1556\/030.2023.02050","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T05:20:30Z","timestamp":1687843230000},"update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of methicillin resistant Staphylococcus aureus wound infection using vancomycin-loaded nanoparticles: An in vitro and in vivo study"],"prefix":"10.1556","author":[{"given":"Hassan Thoulfikar A.","family":"Alamir","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Al-Ameed, Karbala, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Gheni","family":"Taher","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, College of Medicine, University of Diyala, Baquba, Diyala, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazin Razooqi","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Bilad Alrafidain University College, Diyala, 32001, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja Hameed","family":"Kareem","sequence":"additional","affiliation":[{"name":"National University of Science and Technology, Dhi Qar, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-7465","authenticated-orcid":true,"given":"Abduladheem Turki","family":"Jalil","sequence":"additional","affiliation":[{"name":"Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, 51001, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Int J Pharm","article-title":"Prolonged proliferation and delayed senescence of the adipose-derived stem cells grown on the electrospun composite nanofiber co-encapsulated with TiO2 nanoparticles and metformin-loaded mesoporous silica nanoparticles","volume":"604","author":"Pourpirali R","year":"2021","unstructured":"Pourpirali R, Mahmoudnezhad A, Oroojalian F, Zarghami N, Pilehvar Y. 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