{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:57:48Z","timestamp":1773939468262,"version":"3.50.1"},"reference-count":40,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nocardiosis is a rare disease affecting both immunocompromised and immunocompetent hosts, presented in various clinical forms ranging from localized to disseminated infection. Aim of the present study was to investigate the clinical and microbiological characteristics of nocardiosis, antimicrobial resistance profiles, treatment, and outcomes of <jats:italic>Nocardia<\/jats:italic> infection over the last 5 years at our institution. The medical records and microbiological data of patients affected by nocardiosis and treated at the university hospital of Heraklion, Crete, Greece, between 2018 and 2022, were retrospectively analyzed. The isolates were identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and through sequencing of 16S rRNA. Antimicrobial susceptibility for 17 agents was determined by E-test and results were interpreted according to CLSI guidelines. Among the 28 <jats:italic>Nocardia<\/jats:italic> isolates, eight species were identified, with <jats:italic>Nocardia brasiliensis<\/jats:italic> being the most prevalent (32.1%), followed by <jats:italic>Nocardia otitidiscaviarum<\/jats:italic> (25%), and <jats:italic>Nocardia farcinica<\/jats:italic> (14.3%). Skin and soft tissue infections were the most common presentations, noted in 13 (50%) patients, followed by pulmonary\u00a0infection presented in 10 (38.5%) patients. Fifteen patients (57.7%) had at least one underlying disease, and 11 (42.3%) were on immunosuppressive or long-term corticosteroid treatment. Susceptibility rates of linezolid, tigecycline, amikacin, trimethoprim-sulfamethoxazole, moxifloxacin, and imipenem were 100, 100, 96.4, 92.9, 82.1, and 42.9%, respectively. The 26 patients in this study were treated with various antibiotics. Mortality rate was 3.8%, and the patient who died had disseminated infection. Since epidemiology and antimicrobial susceptibility are evolving, continuous surveillance is mandatory in order to initiate appropriate treatment in a timely manner.<\/jats:p>","DOI":"10.1556\/030.2023.02071","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T06:54:45Z","timestamp":1689576885000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and microbiological characteristics of\u00a0nocardiosis: A 5-year single-center study in\u00a0Crete, Greece"],"prefix":"10.1556","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0945-1732","authenticated-orcid":true,"given":"Sofia","family":"Maraki","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria Eirini","family":"Mavromanolaki","sequence":"additional","affiliation":[{"name":"University of Crete Medical School, Heraklion, Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kasimati","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Stafylaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Effie","family":"Scoulica","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology and Molecular Microbiology, School of Medicine, University of Crete, Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Clin Microbiol Rev","first-page":"259","article-title":"Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy","volume":"19","author":"Brown-Elliott BA","year":"2006","unstructured":"Brown-Elliott BA, Brown JM, Conville PS, Wallace RJ Jr. Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. 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