{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:10:00Z","timestamp":1747199400141,"version":"3.40.5"},"reference-count":35,"publisher":"Akademiai Kiado Zrt.","issue":"3","funder":[{"name":"Research Deputy of Shahid Beheshti University of Medical Sciences","award":["33140"],"award-info":[{"award-number":["33140"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increase in antibiotic resistance in <jats:italic>Staphylococcus aureus<\/jats:italic> isolated from ear infection is a serious public health problem. The objective of this investigation was to determine the antibacterial resistance profile and genetic variability of the <jats:italic>S. aureus<\/jats:italic> isolated from adult patients with otitis externa (OE) and otitis media (OM) infections, Tehran- Iran. The disk diffusion was employed to detect the susceptibility of 45\u2009<jats:italic>S. aureus<\/jats:italic> strains. Biofilm production was evaluated by microtiter plate assay. Genetic diversity of the isolates was determined by staphylococcal cassette SCC<jats:italic>mec<\/jats:italic>, <jats:italic>spa<\/jats:italic>, and MLST techniques. Resistance to mupirocin and vancomycin were identified in 40 and 2.2% of isolates. Out of the 45\u2009<jats:italic>S. aureus<\/jats:italic> isolates, 41 (91.2%) strains were considered as positive biofilm strains at different levels. According to our results, <jats:italic>S. aureus<\/jats:italic> isolated from OM (44.4%, 20\/45) were including CC8\/ST239-SCC<jats:italic>mec<\/jats:italic>III corresponded to <jats:italic>spa<\/jats:italic> types t860, t030, t037, t234, t421 (70%, 14\/20) and CC\/ST30-SCC<jats:italic>mec<\/jats:italic>IV corresponded to <jats:italic>spa<\/jats:italic> types t605 and t019 (30%, 6\/20) while <jats:italic>S. aureus<\/jats:italic> isolated from OE (55.6%, 25\/45) were including CC\/ST30-SCC<jats:italic>mec<\/jats:italic>IV corresponded to <jats:italic>spa<\/jats:italic> types t605, t345 and t1130 (52%, 13\/25), CC\/ST22-SCC<jats:italic>mec<\/jats:italic>IV corresponded to <jats:italic>spa<\/jats:italic> type t790 (20%, 5\/25), CC8\/ST8-SCC<jats:italic>mec<\/jats:italic>IV corresponded to <jats:italic>spa<\/jats:italic> type t008 (16%,\u00a04\/25), and CC\/ST45-SCC<jats:italic>mec<\/jats:italic>IV corresponded to <jats:italic>spa<\/jats:italic> types t004 and t038 (12%, 3\/25). This study highlighted genetic variability and strong biofilm formation ability among our isolates revealing its crucial role in enhancing the resistance of this bacteria to drugs. Thus, it is necessary to continue the epidemiological analysis to improve the control of ear infections related to <jats:italic>S. aureus<\/jats:italic>.<\/jats:p>","DOI":"10.1556\/030.2023.02081","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:05:17Z","timestamp":1695020717000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Genetic diversity of Staphylococcus aureus isolated from ear infections in Iran: Emergence of CC8\/ST239-SCCmec III as major genotype"],"prefix":"10.1556","volume":"70","author":[{"given":"Zahra","family":"Rahmani","sequence":"first","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Department of Otorhinolaryngology, Loghman Hospital, Shahid-Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sareh Sadat","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parmida","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-9341","authenticated-orcid":true,"given":"Mehdi","family":"Goudarzi","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Virulence","first-page":"547","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung GY","year":"2021","unstructured":"Cheung GY, Bae JS, Otto M. 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