{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:12:41Z","timestamp":1793679161816,"version":"4.5.1"},"reference-count":29,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis C virus (HCV) can cause both acute and chronic hepatitis infections. Gaziantep is located southeast part of Turkey and has a border with Syria. More than 400,000 Syrian refugees live in Gaziantep. The aim of this study was to evaluate distribution of HCV genotypes among Syrian patients and in people who inject drugs.<\/jats:p><jats:p>Serum samples form 1,628 individuals (786 female, 842 male) which were sent to our laboratory for genotyping between January 2013 and December 2022, were analyzed retrospectively. Three different HCV genotyping assays (Qiagen, RTA and Abbott) were used during the 10-year study period.<\/jats:p><jats:p>Out of the 1,628 patients, genotype 1 was detected in 51.5%, genotype 3 in 21.4%, genotype 4 in 20%, genotype 5 in 4.6%, genotype 2 in 1.3%. Mixed genotype was found in 20 patients. Of the patients, 1,143 were Turkish patients and among those patients genotype 1 (66.8%) was the most common genotype followed by genotype 3 (29%). Among Syrian patients (<jats:italic>n<\/jats:italic> = 477), genotype 4 (64.2%) was predominant genotype followed by genotype 1 and genotype 5. Genotype 3 was detected in 277 (79.6%) prisoners. All of them were male and probably the main source of HCV infection was intravenous drug abuse. While genotypes 1 and 4 were common in females, genotypes 1 and 3 were common in males.<\/jats:p><jats:p>In the future genotype 3 may become an increasing problem due to the persons who inject drugs. Less frequent genotypes such as 4 and 5 may become more frequent due to Syrian patients.<\/jats:p>","DOI":"10.1556\/030.2023.02137","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:18:09Z","timestamp":1697023089000},"page":"348-352","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":3,"title":["Genotype distribution of hepatitis C virus in the\u00a0province of Gaziantep, a 10-year evaluation"],"prefix":"10.1556","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-3766","authenticated-orcid":true,"given":"Osman Sezer","family":"C\u0131r\u0131t","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelda","family":"Demir","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Sa\u0131t","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Ankara Atat\u00fcrk Sanatorium Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"Alpaslan","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Avc\u0131oglu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Abant Izzet Baysal University, Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Gaziantep Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Astam","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Eski\u015fehir City Hospital, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","article-title":"Global hepatitis report","author":"WHO","unstructured":"WHO. Global hepatitis report. Available from: http:\/\/www.who.int\/hepatitis\/publications\/global-hepatitis-report2017\/en\/."},{"key":"B2","unstructured":"https:\/\/www.who.int\/publications\/i\/item\/9789240052734."},{"key":"B3","series-title":"Int J Gen Med","first-page":"39","article-title":"Hepatitis C treatment: where are we now?","volume":"10","author":"Burstow NJ","year":"2017","unstructured":"Burstow NJ, Mohamed Z, Gomaa AI, Sonderup MW, Cook NA, Waked I. Hepatitis C treatment: where are we now? Int J Gen Med 2017;10:39\u201352."},{"key":"B4","series-title":"Int J Mol Sci","first-page":"23","article-title":"Hepatitis C virus: viral quasispecies and genotypes","volume":"19","author":"Tsukiyama-Kohara K","year":"2018","unstructured":"Tsukiyama-Kohara K, Kohara M. Hepatitis C virus: viral quasispecies and genotypes. Int J Mol Sci 2018; 19: 23."},{"issue":"1","key":"B5","series-title":"J Hepatol","first-page":"148","article-title":"The changing epidemiology of hepatitis C virus infection in Europe","volume":"48","author":"Esteban JI","year":"2008","unstructured":"Esteban JI, Sauleda S, Quer J. The changing epidemiology of hepatitis C virus infection in Europe. J Hepatol 2008; 48(1): 148\u2013162."},{"issue":"9","key":"B6","series-title":"Hepat Mon","article-title":"The distribution of hepatitis C virus genotypes in Middle Eastern countries: a systematic review and meta-analysis","volume":"16","author":"Ghaderi-Zefrehi H","year":"2016","unstructured":"Ghaderi-Zefrehi H, Gholami-Fesharaki M, Sharafi H, Sadeghi F, Alavian SM. The distribution of hepatitis C virus genotypes in Middle Eastern countries: a systematic review and meta-analysis. Hepat Mon 2016; 16(9): e40357."},{"issue":"6","key":"B7","series-title":"J\u00a0Hepatol","first-page":"1094","article-title":"Global genotype distribution of hepatitis C viral infection among people who inject drugs","volume":"65","author":"Robaeys G","year":"2016","unstructured":"Robaeys G, Bielen R, Azar DG, Razavi H, Nevens F. Global genotype distribution of hepatitis C viral infection among people who inject drugs. J\u00a0Hepatol 2016;65(6):1094\u20131103."},{"key":"B8","series-title":"J Hepatol","first-page":"S45","article-title":"Global epidemiology and genotype distribution of the hepatitis C virus infection","volume":"61","author":"Gower E","year":"2014","unstructured":"Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol 2014; 61: S45\u2013S57."},{"key":"B9","series-title":"APMIS","first-page":"109","article-title":"Dynamics of HCV epidemiology in Aydin province of Turkey and the associated factors","volume":"126","author":"Kirdar S","year":"2018","unstructured":"Kirdar S, Aydin N, Tiryaki Y, Ertugrul B, Coskun A, Bilgen M. Dynamics of HCV epidemiology in Aydin province of Turkey and the associated factors. APMIS 2018; 126: 109\u2013113."},{"key":"B10","series-title":"Turk Hij Den Biyol Derg","first-page":"201","article-title":"Determination of hepatitis C virus genotype and HCV infection transmission routes in Cukurova University medical faculty hospital","volume":"74","author":"Duran A\u00c7","year":"2017","unstructured":"Duran A\u00c7, Kibar F, \u00c7etiner S, Yaman A. Determination of hepatitis C virus genotype and HCV infection transmission routes in Cukurova University medical faculty hospital. Turk Hij Den Biyol Derg. 2017; 74: 201\u2013210."},{"key":"B11","series-title":"Indian J Med Microbiol","first-page":"416","article-title":"Changes in hepatitis C virus genotype distribution in chronic hepatitis C infection patients","volume":"36","author":"Selek MB","year":"2018","unstructured":"Selek MB, Baylan O, Karag\u00f6z E, \u00d6zyurt M. Changes in hepatitis C virus genotype distribution in chronic hepatitis C infection patients. Indian J Med Microbiol 2018; 36: 416\u2013421."},{"key":"B12","series-title":"Indian J Med Microbiol","first-page":"192","article-title":"Distribution of hepatitis C virus genotypes in Istanbul, Turkey","volume":"36","author":"Karabulut N","year":"2018","unstructured":"Karabulut N, Alacam S, Yolcu A, Onel M, Agacfidan A. Distribution of hepatitis C virus genotypes in Istanbul, Turkey. 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Mersin \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi. 2023; 16(1): 75\u201382."},{"issue":"2","key":"B20","series-title":"Viral Hepat J","first-page":"67","article-title":"Hepatitis C genotype distribution changing through years in the Kahramanmara\u015f region","volume":"28","author":"Gi\u015fi K","year":"2022","unstructured":"Gi\u015fi K, Ispiro\u011flu M, \u015eahin AR, Aral M, Kantar\u00e7eken B. Hepatitis C genotype distribution changing through years in the Kahramanmara\u015f region. Viral Hepat J 2022; 28(2): 67\u201371."},{"issue":"2","key":"B21","series-title":"Turk J Gastroenterol","first-page":"128","article-title":"Changes on Hepatitis C virus genotype distribution in Western Turkey: evaluation of twelve-year data","volume":"31","author":"\u00c7etin Duran A","year":"2020 Feb","unstructured":"\u00c7etin Duran A, Kaya \u00c7etinkaya \u00d6, Say\u0131ner AA, \u015eeydao\u011flu G, \u00d6zkarata\u015f E, Abac\u0131o\u011flu H. 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Epidemiol Infect 2009; 1371: 79\u201384."},{"key":"B27","series-title":"World J Gastroenterol","first-page":"7824","article-title":"Global epidemiology of Hepatitis C Virus (HCV) infection: an up-date of the distribution and circulation of HCV genotypes","volume":"22","author":"Petruzziello A","year":"2016","unstructured":"Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of Hepatitis C Virus (HCV) infection: an up-date of the distribution and circulation of HCV genotypes. World J Gastroenterol 2016; 22: 7824\u20137840."},{"key":"B28","first-page":"382","author":"Yildirim MS","unstructured":"Yildirim MS, Yayla B, Cirit OS. Gaziantep Dr. Ersin Arslan Devlet Hastanesi HCV Genotip Verileri: T\u00fcrkiye\u2019de \u0130lk Genotip 5 Tespiti mi? 2. Ulusal Klinik Mikrobiyoloji Kongresi (2nd National Clinical Microbiology Congress), 10\u201313 Kas\u0131m 2013, Antalya. Kongre Kitab\u0131 sy: 382, PS 432."},{"key":"B29","series-title":"Infect Agents Cancer","first-page":"53","article-title":"Hepatitis C virus (HCV) genotypesdistribution: an epidemiological up-date in Europe","volume":"11","author":"Petruzziello A","year":"2016","unstructured":"Petruzziello A, Marigliano S, Loquercio G, Cacciapuoti C. Hepatitis C virus (HCV) genotypesdistribution: an epidemiological up-date in Europe. 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