{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:45:32Z","timestamp":1792597532246,"version":"4.5.0"},"reference-count":102,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"crossref","award":["BO\/00286\/22\/5"],"award-info":[{"award-number":["BO\/00286\/22\/5"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2023,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    is a major human pathogen as it is responsible for various infections. In the past years hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    (hvKP) emerged and disseminated worldwide. In this review a summary will be given about epidemiology, detection and antibiotic resistance of hypervirulent\n                    <jats:italic>K.\u00a0pneumoniae<\/jats:italic>\n                    . A common feature of hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    is a combined expression of several virulence factors. A mucoviscosus phenotype, certain capsulare serotypes (e.g.: K1, K2, K28, K47, K63) together with additional genetic markers namely,\n                    <jats:italic>magA<\/jats:italic>\n                    ,\n                    <jats:italic>rmpA<\/jats:italic>\n                    or\n                    <jats:italic>iucABCD,<\/jats:italic>\n                    are needed in combinations to achieve the hypervirulent pathotype. Plasmid coded virulence determinants are also detected, that indicates horizontal gene transfer of hypervirulence factors in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    Interestingly, infections caused by hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    occur usually in the community in otherwise healthy people, and during these infections multiple infection sites are detected. Clinical pictures include both invasive infections and local abscess formation. Pyogenic liver abscess is the most frequently reported clinical manifestation and abscess formation in brain, spleen and lung are also diagnosed. Additionally, meningitis, endophthalmitis, trombophlebitis, pneumonia can also develop.\n                  <\/jats:p>\n                  <jats:p>\n                    In the early reports, hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    strains exhibited enhanced virulence but these were susceptible to commonly used antibiotics. However, recently KPC, VIM, NDM and OXA-48 carbapenemase producing hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    strains are increasingly reported, furthermore, well-known high-risk\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    clones (e.g.: ST11, ST147, ST307) can develop hypervirulent pathotype, that poses an even more alarming challenge.\n                  <\/jats:p>","DOI":"10.1556\/030.2023.02186","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T04:36:45Z","timestamp":1701664605000},"page":"278-287","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":49,"title":["Hypervirulent Klebsiella pneumoniae: An update on epidemiology, detection and antibiotic resistance"],"prefix":"10.1556","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7067-7055","authenticated-orcid":true,"given":"B\u00e9la","family":"Kocsis","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"3","key":"B1","series-title":"FEMS Microbiol Rev","first-page":"252","article-title":"Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance","volume":"41","author":"Navon-Venezia S","year":"2017","unstructured":"Navon-Venezia S, Kondratyeva K, Carattoli A. 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