{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:59:22Z","timestamp":1787317162331,"version":"build-2736575974"},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"Abstract<\/jats:title>\n \n Klebsiella pneumoniae<\/jats:italic>\n is a major human pathogen, because it causes both community- and hospital-acquired infections. Several multidrug-resistant high-risk clones of\n K. pneumoniae<\/jats:italic>\n have been reported worldwide, and these are responsible for high numbers of difficult-to-treat infections. In Greece, a\n K.\u00a0pneumoniae<\/jats:italic>\n ST39 high-risk clone was detected in 2019 in a survey of carbapenem- and\/or colistin-resistant Enterobacteriacae. The present study included nine carbapenem-resistant\n K. pneumoniae<\/jats:italic>\n (CRKP) isolates collected during a retrospective analysis from October 2020 to December 2020. They were isolated from nine different patients hospitalized in the intensive care unit (ICU) of a hospital in Volos, Greece, and they were selected for analysis due to their phenotypic profile. In this study, we analyzed A165 strain\n K. pneumoniae<\/jats:italic>\n ST39 isolated from a blood culture in November 2020. Whole-genome sequencing (WGS) was performed using Ion Torrent Platform, and resistance genes, virulence determinants, capsular types, insertion sequences, phage regions, and clustered regularly interspaced palindromic repeats (CRISPR) regions were detected by bioinformatic analysis. The molecular characterization\u00a0revealed antimicrobial resistance genes, including\n sul2<\/jats:italic>\n for sulfamethoxazole;\n dfr<\/jats:italic>\n A1 for\u00a0trimethoprim;\n bla<\/jats:italic>\n VIM-1<\/jats:sub>\n and\n bla<\/jats:italic>\n KPC-2<\/jats:sub>\n for carbapenems;\n aac<\/jats:italic>\n (6\u2032)-II for aminoglycosides;\n fos<\/jats:italic>\n A for\u00a0fosfomycin and\n aad1<\/jats:italic>\n for streptomycin,\n bla<\/jats:italic>\n SHV-40<\/jats:sub>\n ,\n bla<\/jats:italic>\n SHV-85<\/jats:sub>\n ,\n bla<\/jats:italic>\n SHV-79<\/jats:sub>\n ,\n bla<\/jats:italic>\n SHV-56<\/jats:sub>\n , and\n bla<\/jats:italic>\n SHV-89<\/jats:sub>\n for\u00a0beta-lactams. Point mutations were identified in\n ompK36<\/jats:italic>\n , and\n ompK37<\/jats:italic>\n and in\n acrR, gyrA, parC<\/jats:italic>\n . Several replicons were found, including CoIRNA, IncC, IncFIB(K), IncFIB(pQiL), and IncFII(K). The\u00a0capsular typing revealed that the strain was KL23, O2afg. The genome sequence of A165 was submitted to NCBI under PRJNA1074377 and have been assigned to Genbank accession number JAZIBV000000000.\n <\/jats:p>","DOI":"10.1556\/030.2024.02226","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T07:14:07Z","timestamp":1709795647000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":6,"title":["KPC-2 and VIM-1 producing Klebsiella pneumoniae ST39 high-risk clone isolated from a\u00a0clinical sample in Volos, Greece"],"prefix":"10.1556","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-4546","authenticated-orcid":true,"given":"Maria","family":"Chatzidimitriou","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Health, International Hellenic University, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandora","family":"Tsolakidou","sequence":"additional","affiliation":[{"name":"Achillopoulio General Hospital of Volos, Thessaly, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatzivasileiou","family":"Panagiota","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Health, International Hellenic University, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Mylona","sequence":"additional","affiliation":[{"name":"Health Center, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Mitka","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Health, International Hellenic University, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Microb Pathog","article-title":"High mortality from carbapenem-resistant Klebsiella pneumoniae bloodstream infection","volume":"167","author":"Soares de Moraes L","year":"2022 Jun","unstructured":"Soares de Moraes L, Gomes Magalhaes GL, Material Soncini JG, Pelisson M, Eches Perugini MR, Vespero EC. 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