{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:00:55Z","timestamp":1777658455695,"version":"3.51.4"},"reference-count":57,"publisher":"Akademiai Kiado Zrt.","issue":"2","funder":[{"name":"The Scientific and Technological Research Council of Turkey","award":["116S290"],"award-info":[{"award-number":["116S290"]}]},{"name":"The Scientific and Technological Research Council of Turkey","award":["1919B012101060"],"award-info":[{"award-number":["1919B012101060"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prosthetic joint infection (PJI) and aseptic loosening (AL) are common complications of total joint arthroplasty. An accumulation of evidence indicates the presence of microbial communities on prosthetic implants, but the overall microbial profile is unclear. In this study, we aimed to investigate the differences in the microbial composition of prosthetic implants obtained from PJI and AL patients using the 16S rRNA sequencing method. Patients who underwent revision hip, knee, or shoulder arthroplasty caused by PJI (<jats:italic>n<\/jats:italic> = 20) or AL (<jats:italic>n<\/jats:italic> = 10) were enrolled in the study. 16S rRNA sequencing targeting the V3\u2013V4 region was performed on the microbial specimens collected from synovial fluid, periprosthetic deep-tissue, and biofilm during the revision surgery. The sequenced raw data were analysed for microbial composition and ecological and differential abundance analyses using bioinformatics tools. The AL group had relatively balanced and higher diversity, with <jats:italic>Staphylococcus<\/jats:italic>, <jats:italic>Streptococcus<\/jats:italic>, and <jats:italic>Veillonella<\/jats:italic> being prominent. In the PJI group, <jats:italic>Staphylococcus<\/jats:italic> and <jats:italic>Pseudomonas<\/jats:italic> were predominant, especially in deep-tissue samples and biofilm samples, respectively. The differential abundance analysis identified 15 and 2 distinctive taxa in the AL and PJI groups, respectively. Our findings provided preliminary insights supporting the existence of periprosthetic microbiota in orthopedic implants and explaining the differences in microbial composition between the AL and PJI groups.<\/jats:p>","DOI":"10.1556\/030.2024.02265","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T15:43:35Z","timestamp":1713195815000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["16S rRNA sequencing reveals microbiota differences in orthopedic implants between aseptic loosening and prosthetic joint infection cases"],"prefix":"10.1556","volume":"71","author":[{"given":"Omer Faruk","family":"Cetiner","sequence":"first","affiliation":[{"name":"Istanbul Faculty of Medicine, Istanbul University, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Hora","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics Systems Biology, Institute of Health Sciences, Erciyes University, Kayseri, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Halil","family":"Kafadar","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Erciyes University, Kayseri, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysegul","family":"Ulu Kilic","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-8464","authenticated-orcid":true,"given":"Aycan","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, T\u00fcrkiye"},{"name":"Metagenomics Laboratory, Genome and Stem Cell Center (GenKok), Erciyes University, Kayseri, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"issue":"9","key":"B1","series-title":"The J Rheumatol","first-page":"1134","article-title":"Rates of total joint replacement in the United States: future projections to 2020\u20132040 using the national inpatient sample","volume":"46","author":"Singh JA","year":"2019","unstructured":"Singh JA, Yu S, Chen L, Cleveland JD. 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