{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:10:09Z","timestamp":1747199409899,"version":"3.40.5"},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this prospective pilot study was to compare culture and microbiome results of the removed tonsils of patients with assumed distant focal disease (11 patients) and those who underwent a tonsillectomy, due to other reasons, such as recurrent tonsillitis, tonsil stones or snoring (nine patients). Aerobic culture was carried out for samples taken from the surface of the tonsils by swabs before tonsillectomy for all 20 patients. The squeezed detritus and the tissue samples of removed tonsils, taken separately for the right and left tonsils, were incubated aerobically and anaerobically. The microbiome composition of tissue samples of removed tonsils was also evaluated. Based on the culture results of the deep samples <jats:italic>Staphylococcus aureus<\/jats:italic> was the dominating pathogen, besides a great variety of anaerobic and facultative anaerobic bacteria present in the oral microbiota in those patients who underwent tonsillectomy due to distant focal diseases. Microbiome study of the core tissue samples showed a great diversity on genus and species level among patients of the two groups however, <jats:italic>S. aureus<\/jats:italic> and <jats:italic>Prevotella nigrescens<\/jats:italic> were present in higher proportion in those, whose tonsils were removed due to distant focal diseases. Our results may support previous findings about the possible triggering role of <jats:italic>S. aureus<\/jats:italic> and <jats:italic>P.\u00a0nigrescens<\/jats:italic> leading to distant focal diseases. Samples taken by squeezing the tonsils could give more information about the possible pathogenic\/triggering bacteria than the surface samples cultured only aerobically.<\/jats:p>","DOI":"10.1556\/030.2024.02279","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:57:04Z","timestamp":1719583024000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Comparative evaluation of culture results and composition of microbiome of removed tonsils due to distant focal disease or other reasons. A\u00a0prospective pilot study"],"prefix":"10.1556","volume":"71","author":[{"given":"Zsolt","family":"Bella","sequence":"first","affiliation":[{"name":"Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary"},{"name":"Maxillofacial and Oto-Rhino-Laryngology Department, B\u00e1cs-Kiskun County Teaching Hospital, Kecskem\u00e9t, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Erd\u00e9lyi","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Kiricsi","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Ga\u00e1l","sequence":"additional","affiliation":[{"name":"Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Mar\u00f3ti","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Center, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Sciences and Informatics, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"S\u00f3ki","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-1879","authenticated-orcid":true,"given":"Elisabeth","family":"Nagy","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Lancet","first-page":"1795","article-title":"Focal infection","volume":"360","author":"Bynum B","year":"2002","unstructured":"Bynum B. 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