{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:19:28Z","timestamp":1780406368343,"version":"3.54.1"},"reference-count":20,"publisher":"Akademiai Kiado Zrt.","issue":"4","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2024,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Escherichia coli<\/jats:italic> A382 was isolated in July 2024 from a positive blood culture obtained from the central venous catheter of a male patient undergoing chemotherapy at the Hospital of Volos, Thessaly, Greece. Whole-genome sequencing analysis revealed that the isolate A382 is <jats:italic>E. coli<\/jats:italic> belonging to the ST410 high-risk clone, which co-harbors the <jats:italic>bla<\/jats:italic><jats:sub>KPC-3<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>SHV-182<\/jats:sub> genes on an IncX3 plasmid. It also harbors <jats:italic>bla<\/jats:italic><jats:sub>TEM-1<\/jats:sub> and has five replicons, as follows: IncX3, IncQ1, CoIRNAI, IncF1A, and IncFIB. Complete genome analysis revealed that <jats:italic>E. coli<\/jats:italic> A382 isolate carries a range of virulence factors (<jats:italic>iutA<\/jats:italic>, <jats:italic>iucC<\/jats:italic>, <jats:italic>fimH<\/jats:italic>, <jats:italic>fdeC<\/jats:italic>, <jats:italic>yehA<\/jats:italic>, <jats:italic>yehD<\/jats:italic>, <jats:italic>yehC<\/jats:italic>, <jats:italic>yehB<\/jats:italic>, <jats:italic>cgs<\/jats:italic>, <jats:italic>ahha<\/jats:italic>, <jats:italic>ccI<\/jats:italic>, <jats:italic>hlyE<\/jats:italic>, <jats:italic>papC<\/jats:italic>, <jats:italic>irp2<\/jats:italic>, <jats:italic>fyuA<\/jats:italic>, <jats:italic>lpfA<\/jats:italic>, and <jats:italic>nlpl<\/jats:italic>) and many other non-beta-lactam resistance determinants, including <jats:italic>dfrA14<\/jats:italic> and <jats:italic>sul2<\/jats:italic>, but it is susceptible to aminoglycosides, nitrofurantoin, tigecycline, colistin and ceftazidime-avibactam. In conclusion in this study, we describe the phenotypic and genome characteristics of an extensively drug-resistant <jats:italic>E. coli<\/jats:italic> ST410.<\/jats:p>","DOI":"10.1556\/030.2024.02376","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T06:59:43Z","timestamp":1726642783000},"page":"285-288","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Detection of KPC-3 producing Escherichia coli ST410 in Volos, Greece"],"prefix":"10.1556","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-4546","authenticated-orcid":true,"given":"Maria","family":"Chatzidimitriou","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandora","family":"Tsolakidou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital of Volos, Polymeri 134, 38222 Volos, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Anna","family":"Kyriazidi","sequence":"additional","affiliation":[{"name":"Georgios Papanikolaou, General Hospital of Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Mitka","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Appl Environ Microbiol","article-title":"The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 Years in France","volume":"88","author":"Marin J","year":"2022","unstructured":"Marin J, Clermont O, Royer G, Mercier-Darty M, Decousser JW, Tenaillon O, et\u00a0al. 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