{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:07:07Z","timestamp":1791684427616,"version":"4.3.4"},"reference-count":53,"publisher":"Akademiai Kiado Zrt.","issue":"2","funder":[{"name":"Faculty of Medicine Vajira Hospital, Navamindradhiraj University"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2025,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multidrug resistant (MDR) gram-negative bacilli associated with hospital-acquired infections are commonly resistant to carbapenems. <jats:italic>Klebsiella pneumoniae<\/jats:italic> is a common MDR <jats:italic>Enterobacterales<\/jats:italic> in Thailand. In this study, we investigated the distribution of five carbapenemase genes (<jats:italic>bla<\/jats:italic><jats:sub>NDM<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>OXA-48<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>IMP<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>VIM<\/jats:sub>, and <jats:italic>bla<\/jats:italic><jats:sub>KPC<\/jats:sub>) among 62 carbapenem resistant <jats:italic>K. pneumoniae<\/jats:italic> (CRKP) collected in 2022 from patients admitted to a tertiary care hospital in Bangkok. The frequencies of isolates carrying a single carbapenamase gene were 39% for <jats:italic>bla<\/jats:italic><jats:sub>OXA-48<\/jats:sub> and 19% for <jats:italic>bla<\/jats:italic><jats:sub>NDM<\/jats:sub>. Interestingly the frequency of\u00a0the carriers of both genes was as high as 29% and none of the isolates carried <jats:italic>bla<\/jats:italic><jats:sub>KPC<\/jats:sub>, commonly reported elsewhere. The studied genes were not identified in 7 isolates (11%). CRKP carrying <jats:italic>bla<\/jats:italic><jats:sub>NDM<\/jats:sub> was more frequently identified in medical wards, associated with higher mortality rate and 100% resistant to ceftazidime\/avibactam while the one carrying only <jats:italic>bla<\/jats:italic><jats:sub>OXA-48<\/jats:sub> was 92% susceptible to ceftazidime\/avibactam. This study confirms the advantage of molecular methods for differentiating between mechanisms of carbapenem resistance in <jats:italic>K. pneumoniae.<\/jats:italic><\/jats:p>","DOI":"10.1556\/030.2025.02599","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:27:33Z","timestamp":1749536853000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":2,"title":["Diversity of carbapenemase genes among carbapenem resistant Klebsiella pneumoniae in\u00a0a\u00a0tertiary care hospital in Bangkok, Thailand"],"prefix":"10.1556","volume":"72","author":[{"given":"Anchalee","family":"Homkaew","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanwa","family":"Wongsuk","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriphan","family":"Boonsilp","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutturong","family":"Ckumdee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padungsri","family":"Dubbs","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-6719","authenticated-orcid":true,"given":"Prasit","family":"Palittapongarnpim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand"},{"name":"Pornchai Matangkasombut Center for Microbial Genomics, Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"6","key":"B1","series-title":"Clin Transl Sci","article-title":"Mortality factors and antibiotic options in carbapenem-resistant Enterobacterales bloodstream infections: insights from a high-prevalence setting with co-occurring NDM-1 and OXA-48","volume":"17","author":"Karnmueng P","year":"2024","unstructured":"Karnmueng P, Montakantikul P, Paiboonvong T, Plongla R, Chatsuwan T, Chumnumwat S. 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