{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:19:04Z","timestamp":1790378344398,"version":"4.1.0"},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"4","funder":[{"name":"Hacettepe University Scientific Research Project Unit","award":["THD-2021-19334"],"award-info":[{"award-number":["THD-2021-19334"]}]}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2025,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Invasive fungal infections caused by resistant\n                    <jats:italic>Candida<\/jats:italic>\n                    species are a global public health problem. Increasing antifungal resistance makes antifungal susceptibility tests (AFST) crucial, necessitating rapid methods. This study aims to determine the fluconazole and anidulafungin susceptibility profiles of clinical\n                    <jats:italic>Candida<\/jats:italic>\n                    strains using matrix assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and compare the results with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) reference broth microdilution method to assess the accuracy and reproducibility of MALDI-TOF MS in evaluating\n                    <jats:italic>in vitro<\/jats:italic>\n                    antifungal susceptibility. The susceptibilities of 40\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    isolates for anidulafungin and fluconazole, and 40\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and 40\u00a0\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    isolates for fluconazole were tested.\n                    <jats:italic>Candida<\/jats:italic>\n                    isolates were incubated for 3\u2009h at two different antifungal concentrations (\u201cmaximum\u201d and \u201cbreakpoint\u201d concentrations) and a drug-free control (Anidulafungin: 16, 0.06, and 0\u2009mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; Fluconazole: 256, 16, and 0\u2009mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). MALDI-TOF MS spectra from these concentrations were used to create composite correlation index (CCI) matrices for each isolate. The strains with the \u201cmean CCI of the breakpoint\/maximum concentration\u201d of which was higher than the \u201cmean CCI of the breakpoint\/null concentration\u201d were classified as susceptible. Classifications defined by the MS-AFST method were compared to those based on the EUCAST broth microdilution method. The overall agreement between MS-AFST and EUCAST AFST ranged from 60% to 85%, highest for\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and anidulafungin. The reproducibility of the MS-AFST assay ranged from 45% to 75%, highest for\n                    <jats:italic>C. parapsilosis<\/jats:italic>\n                    and fluconazole. The study suggests that the MALDI-TOF MS method for assessing antifungal susceptibility in\n                    <jats:italic>Candida<\/jats:italic>\n                    strains is promising but requires further improvements for enhancing the accuracy and reproducibility.\n                  <\/jats:p>","DOI":"10.1556\/030.2025.02678","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:55:17Z","timestamp":1761900917000},"page":"390-396","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Rapid detection of anidulafungin and fluconazole susceptibility profiles of clinical Candida strains by MALDI-TOF MS"],"prefix":"10.1556","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6713-7982","authenticated-orcid":true,"given":"Ilke","family":"Toker Onder","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-7590","authenticated-orcid":true,"given":"Alpaslan","family":"Alp","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-6764","authenticated-orcid":true,"given":"Sevtap","family":"Arikan-Akdagli","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Methods Mol Biol","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-1-4939-6515-1_2","article-title":"The changing epidemiology of invasive fungal infections","volume":"1508","author":"Enoch DA","year":"2017","unstructured":"Enoch DA, Yang H, Aliyu SH, Micallef C. 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