{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:28:17Z","timestamp":1760056097042,"version":"build-2065373602"},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"3","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2025,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Campylobacteriosis is the most frequent zoonosis in Europe and its most important human pathogens are <jats:italic>Campylobacter jejuni<\/jats:italic> and <jats:italic>Campylobacter coli<\/jats:italic>. Resistance of <jats:italic>Campylobacter<\/jats:italic> to fluoroquinolones and tetracyclines, previously recommended for treatment of prolonged or complicated disease, has been emerging. We examined phenotypic resistance to erythromycin, tetracycline, ciprofloxacin, gentamicin, amoxicillin-clavulanic acid and imipenem in 150 <jats:italic>Campylobacter<\/jats:italic> isolates from human stool during 2010\u20132011 and the same number of strains during 2023\u20132024, using the antimicrobial gradient method in both periods, to determine minimum inhibitory concentration (MIC). Comparing the two periods, resistance rate of <jats:italic>C. jejuni<\/jats:italic> increased by 35% and 38.43% to tetracyclin and ciprofloxacin, respectively and decreased by 0.83% to erythromycin. Prevalence of resistance in <jats:italic>C. coli<\/jats:italic> increased by 42.59% and 42.01% against tetracyclin and ciprofloxacin, respectively and all isolates were sensitive to erythromycin. Resistance of <jats:italic>C. jejuni<\/jats:italic> to amoxicillin-clavulanic acid decreased by 0.96% and increased by 3.70% in <jats:italic>C.\u00a0coli<\/jats:italic>. All isolates showed sensitivity for imipenem in both periods, while only 2% of <jats:italic>C. jejuni<\/jats:italic> strains were resistant to gentamicin in 2023\u20132024. The difference of mean MICs for all antibiotics was statistically significant in two examined periods, with exception of those for erythromycin both in <jats:italic>C. jejuni<\/jats:italic> and <jats:italic>C. coli.<\/jats:italic> In 2023\u20132024, 79 isolates of <jats:italic>C. jejuni<\/jats:italic> and 22 isolates of <jats:italic>C. coli<\/jats:italic> were resistant against two and more antibiotics, most frequently tetracycline and ciprofloxacin. The present study provides evidence that in <jats:italic>Campylobacter<\/jats:italic> spp. the antimicrobial resistance to ciprofloxacin and tetracycline is on rise in Serbia. Our findings are in accordance with recent reports from countries geographically close to Serbia.<\/jats:p>","DOI":"10.1556\/030.2025.02685","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:18:11Z","timestamp":1758791891000},"page":"256-260","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial resistance rates of Campylobacter species isolated from clinical samples during 2010\u20132011 and 2023\u20132024 in Serbia"],"prefix":"10.1556","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-2720","authenticated-orcid":true,"given":"Zoran","family":"Tambur","sequence":"first","affiliation":[{"name":"Faculty of Stomatology, University Business Academy in Novi Sad, Pan\u010devo, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Miljkovi\u0107-Selimovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Bio\u010danin","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology, University Business Academy in Novi Sad, Pan\u010devo, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Stanojevi\u0107","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kljaji\u0107","sequence":"additional","affiliation":[{"name":"City Institute of Public Health, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Rakonjac","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Bulaji\u0107","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"ECDC. Annual epidemiological report for 2022","article-title":"Campylobacteriosis","author":"European Centre for Disease Prevention and Control","year":"2024","unstructured":"European Centre for Disease Prevention and Control. Campylobacteriosis. In: ECDC. Annual epidemiological report for 2022. Stockholm: ECDC; 2024."},{"issue":"17(1)","key":"B2","series-title":"Ann Clin Microbiol Antimicrob","first-page":"23","article-title":"Antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli: comparison between Etest and a broth dilution method","volume":"23","author":"Azrad M","year":"2018","unstructured":"Azrad M, Tkhawkho L, Isakovich N, Nitzan O, Peretz A. Antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli: comparison between Etest and a broth dilution method. 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Antibiotic susceptibility profiles among campylobacter isolates obtained from international travelers between 2007 and 2014. Eur J Clin Microbiol Infect Dis 2017; 36(11): 2101\u20132107."},{"issue":"12(3)","key":"B5","series-title":"Microorganisms","first-page":"426","article-title":"Phenotypic antimicrobial resistance profiles of human campylobacter species isolated in Northwest Italy, 2020\u20132023","volume":"20","author":"Tramuta C","year":"2024","unstructured":"Tramuta C, Garcia-Vozmediano A, CeRTiS Clinical Laboratories Group, Maurella C, Bianchi DM, Decastelli L, et\u00a0al. Phenotypic antimicrobial resistance profiles of human campylobacter species isolated in Northwest Italy, 2020\u20132023. 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