{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:02:32Z","timestamp":1780077752399,"version":"3.54.0"},"reference-count":126,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMICR"],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence of fungaemia caused by rare yeasts, particularly\n                    <jats:italic>Trichosporon<\/jats:italic>\n                    species, is rising globally, posing diagnostic and therapeutic challenges\u2014especially in immunocompromised patients. This systematic review aims to analyse the epidemiology, diagnostic approaches, antifungal susceptibility, and clinical outcomes of\n                    <jats:italic>Trichosporon<\/jats:italic>\n                    fungaemia (TF) in South-Eastern Europe, including Turkey. A comprehensive search was conducted in PubMed and Scopus in August 2025. A total of 59 cases from 12 studies were identified, with\n                    <jats:italic>Trichosporon asahii<\/jats:italic>\n                    being the most prevalent species (86.4%). Cases originated from Turkey (79.7%), Greece (18.6%), and Croatia (1.7%). Diagnostic techniques varied, with phenotypic methods still widely used. MALDI-TOF MS and DNA sequencing were mainly applied as confirmatory methods. Haematologic disorders were the most frequently reported underlying conditions among the patients. Sixteen breakthrough fungaemia cases\u2014occurring despite empirical or prophylactic antifungal therapy\u2014were identified. Although rare, TF represents a severe infection with significant mortality in South-Eastern Europe. Early and accurate species identification\u2014facilitated by advanced diagnostic tools\u2014is crucial for effective management. In addition to diagnostic difficulties, treatment is also challenging. Voriconazole appears to be the preferred antifungal agent, even in breakthrough fungaemia cases. Enhanced awareness, routine use of molecular diagnostics, and ongoing epidemiological monitoring are essential to improve patient outcomes.\n                  <\/jats:p>","DOI":"10.1556\/030.2026.02852","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:23:34Z","timestamp":1769412214000},"page":"143-156","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of fungaemia caused by Trichosporon species in South-Eastern Europe"],"prefix":"10.1556","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1228-9707","authenticated-orcid":true,"given":"Sotirios","family":"Varlamis","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, International Hellenic University, Thessaloniki, 57400, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Pessach","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, International Hellenic University, Thessaloniki, 57400, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Anna","family":"Kyriazidi","sequence":"additional","affiliation":[{"name":"1st Propedeutic Department of Internal Medicine Medical School, Aristotle University of Thessaloniki, Thessaloniki, 54642, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Gavriilaki","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, 54642, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mavridou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, International Hellenic University, Thessaloniki, 57400, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Mitka","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, International Hellenic University, Thessaloniki, 57400, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chatzidimitriou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, International Hellenic University, Thessaloniki, 57400, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoleon-Achilleas","family":"Vyzantiadis","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54642, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"B1","series-title":"Mycopathologia","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11046-023-00757-7","article-title":"The epidemiology and clinical characteristics of fungemia in a tertiary hospital in southern China: a 6-year retrospective study","volume":"188","author":"Chen M","year":"2023","unstructured":"Chen M, Hu D, Li T, Zheng D, Liao W, Xia X, et al. 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