{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:59:18Z","timestamp":1788814758047,"version":"build-2803163510"},"reference-count":112,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMICR"],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"Abstract<\/jats:title>\n \n Acinetobacter baumannii<\/jats:italic>\n is a major cause of hospital-acquired infections and has emerged as a critical multidrug-resistant (MDR) pathogen with limited therapeutic options. In this study, two MDR clinical isolates from a tertiary care hospital in Chennai, India, selected based on their strong biofilm-producing capacity, were subjected to whole-genome sequencing (WGS) to characterize their resistome, virulome, and genomic features. Both isolates exhibited resistance to \u03b2-lactams, carbapenems, aminoglycosides, fluoroquinolones, and trimethoprim-sulfamethoxazole, while remaining susceptible to tigecycline and colistin. Genomic analysis identified key carbapenemase genes\n bla<\/jats:italic>\n OXA-23,<\/jats:sub>\n bla<\/jats:italic>\n OXA-51,<\/jats:sub>\n and\n bla<\/jats:italic>\n OXA-144<\/jats:sub>\n along with additional resistance determinants including\n bla<\/jats:italic>\n ADC-76<\/jats:sub>\n and\n bla<\/jats:italic>\n PER-7<\/jats:sub>\n , aminoglycoside-modifying enzymes (\n ant(3\u2033)-Ia<\/jats:italic>\n and\n aph(6)<\/jats:italic>\n ), tetracycline resistance genes (\n tet(A), tet(B),<\/jats:italic>\n and\n tet(R)<\/jats:italic>\n ), macrolide resistance gene\n msr(E)<\/jats:italic>\n , sulfonamide resistance gene\n sul1<\/jats:italic>\n , and chloramphenicol efflux gene\n cmlA5<\/jats:italic>\n . Fluoroquinolone resistance was associated with mutations in the quinolone resistance determining regions, including an S81L substitution in\n gyrA<\/jats:italic>\n and multiple substitutions in\n parC<\/jats:italic>\n . Virulence profiling revealed biofilm-associated genes, including\n bap<\/jats:italic>\n and the\n pgaABC<\/jats:italic>\n operon, along with genes linked to motility and metabolic fitness. Phylogenomic analysis showed close relatedness between the isolates and reference strains, and multilocus sequence typing (MLST) assigned both isolates to sequence type ST1051, indicating a shared clonal background. The genomes also harbored diverse mobile genetic elements, prophage regions, and siderophore-associated biosynthetic gene clusters, reflecting high genomic plasticity. Overall, this study highlights the coexistence of multiple resistance and virulence determinants in biofilm-forming MDR\n A. baumannii<\/jats:italic>\n , emphasizing the importance of genome-based surveillance for monitoring high-risk strains in clinical settings.\n <\/jats:p>","DOI":"10.1556\/030.2026.02983","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:02:16Z","timestamp":1779782536000},"page":"168-181","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive whole-genome sequencing reveals the resistome, virulome, and mobile genetic architecture of multidrug-resistant Acinetobacter baumannii"],"prefix":"10.1556","volume":"73","author":[{"given":"Kannika Parameshwari","family":"Kannan","sequence":"first","affiliation":[{"name":"Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai 600077, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-0064","authenticated-orcid":true,"given":"A.S. Smiline","family":"Girija","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai 600077, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"6","key":"B1","series-title":"Crit Rev Microbiol","first-page":"1270","article-title":"From resistance to treatment: the ongoing struggle with Acinetobacter baumannii","volume":"51","author":"Naseef PN","year":"2025","unstructured":"Naseef PN, Valsa V, Ganesh PS, Gopal RK. From resistance to treatment: the ongoing struggle with Acinetobacter baumannii. 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