{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:05:12Z","timestamp":1790262312034,"version":"4.1.0"},"reference-count":62,"publisher":"Akademiai Kiado Zrt.","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMICR"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This single-centre cross-sectional study aimed to explore serum metabolomic and gut microbiota signatures in patients with Sj\u00f6gren disease (SjD) complicated by anxiety disorder, with emphasis on microbe-metabolite crosstalk, to screen differential omics features and identify clinically relevant microbial\u00a0and metabolic markers stratified by anxiety severity and SjD disease activity. A total of 59 SjD patients were enrolled, and all participants underwent serum untargeted metabolomics and faecal 16S\u00a0rRNA gene sequencing. Participants were stratified according to the median Hamilton Anxiety Scale (HAMA) and European Alliance of Associations for Rheumatology (EULAR) Sj\u00f6gren's Syndrome Disease Activity Index (ESSDAI) scores, and separate Pearson correlation analyses were performed between core clinical indicators and differential gut microbiota as well as serum metabolites. Five altered metabolites involved in purine and tyrosine metabolism were identified. SjD patients with anxiety exhibited enriched pro-inflammatory microbes and depleted anti-inflammatory commensals. Random-forest modelling identified\n                    <jats:italic>Barnesiella<\/jats:italic>\n                    ,\n                    <jats:italic>Lachnoclostridium<\/jats:italic>\n                    and\n                    <jats:italic>Veillonella<\/jats:italic>\n                    as key discriminative genera; notably,\n                    <jats:italic>Lachnoclostridium<\/jats:italic>\n                    abundance showed a positive correlation with serum roccellic acid and N-(9-oxodecy) acetamide, indicating direct gut-circulating metabolite interplay. Subgroup analyses demonstrated gradient shifts of these core markers alongside increasing anxiety and disease severity, and\n                    <jats:italic>Ligilactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Lachnoclostridium,<\/jats:italic>\n                    xanthosine and 2,5-dihydroxybenzaldehyde were validated as anxiety-specific biomarkers. Collectively, SjD patients with anxiety display coordinated perturbations in serum metabolites and gut microbiota, and stratified correlation analyses yield novel microbiology-based, clinically interpretable biomarkers for identifying SjD patients complicated with anxiety disorder.\n                  <\/jats:p>","DOI":"10.1556\/030.2026.03008","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:22:51Z","timestamp":1790259771000},"update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Serum metabolomics and gut microbiota characterisation in patients with Sj\u00f6gren disease complicated by anxiety disorder"],"prefix":"10.1556","author":[{"given":"Shuang","family":"Zhao","sequence":"first","affiliation":[{"name":"Medical Record Management Department, First Hospital of Shanxi Medical University, Taiyuan City, Shanxi, 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyin","family":"Li","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianling","family":"Dong","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daihua","family":"Deng","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tian","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Gao","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoShuang","family":"Yin","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-ang","family":"Luo","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang City, Sichuan, 621000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8190-5851","authenticated-orcid":true,"given":"Jinmei","family":"Zou","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of 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