{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:56:50Z","timestamp":1791381410333,"version":"4.3.3"},"reference-count":25,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["www.akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMICR"],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We evaluated Weifuchun tablets (composed of red ginseng, chamomile, and roasted shell) for preventing intestinal polyp recurrence and treating mucosal lesions after endoscopic resection, and to analyze its mechanism via gut microbiome regulation. This study prospectively enrolled 218 patients who underwent endoscopic intestinal polyp resection (April 2022\u2013April 2024). The observation group (\n                    <jats:italic>n<\/jats:italic>\n                    = 109) received routine postoperative care plus oral Weifuchun tablets for three months, while the control group (\n                    <jats:italic>n<\/jats:italic>\n                    = 109) received routine care alone. Propensity score matching (PSM) was used to balance baseline characteristics. Primary outcomes included one-year polyp recurrence, mucosal injury scores, and gut microbiome alterations (16S rDNA sequencing). Safety and independent protective factors for recurrence (multivariate logistic regression) were also assessed. After PSM, the observation group had a significantly lower one-year recurrence rate than the control group (31.00% vs. 42.16%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.025). Weifuchun significantly reduced intestinal mucosal injury scores (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Crucially, microbiome analysis revealed that Weifuchun markedly increased gut microbial diversity (Sorensen index,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) and significantly boosted the relative abundance of beneficial bacteria such as\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    \u00a0and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , while decreasing harmful bacteria including\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Furthermore, Weifuchun significantly reduced postoperative complications (2.00% vs. 8.82%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.032) and was identified as an independent protective factor against recurrence (OR = 0.456, 95% CI: 0.304\u20130.683,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Weifuchun effectively prevents polyp recurrence and promotes mucosal repair post-endoscopic resection. Its mechanism is closely linked to beneficial modulation of the gut microbiome, restoring microbial balance and enhancing the intestinal microenvironment, and demonstrates a favorable safety profile.\n                  <\/jats:p>","DOI":"10.1556\/030.2026.03051","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:23:06Z","timestamp":1788434586000},"page":"405-415","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety evaluation of Weifuchun in\u00a0preventing recurrence and treating mucosal lesions after endoscopic resection of intestinal polyps: A potential modulation of gut microbiome"],"prefix":"10.1556","volume":"73","author":[{"given":"Pengcheng","family":"Chu","sequence":"first","affiliation":[{"name":"Department of gastroenterology, Deqing County People's Hospital, Huzhou City, 313000, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of gastroenterology, Deqing County People's Hospital, Huzhou City, 313000, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"7","key":"B1","series-title":"J Gastroenterol Hepatol","first-page":"1222","article-title":"Human intestinal spirochetosis, irritable bowel syndrome, and colonic polyps: a systematic review and meta-analysis","volume":"37","author":"Fan K","year":"2022","unstructured":"Fan K, Eslick GD, Nair PM, Burns GL, Walker MM, Hoedt EC, et\u00a0al. Human intestinal spirochetosis, irritable bowel syndrome, and colonic polyps: a systematic review and meta-analysis. J Gastroenterol Hepatol 2022; 37(7): 1222\u201334."},{"issue":"10","key":"B2","series-title":"World J Gastrointest Oncol","article-title":"Clinical outcomes of nursing interventions after endoscopic treatment for intestinal polyps and early-stage cancer","volume":"17","author":"Zhuang YY","year":"2025","unstructured":"Zhuang YY, Chen HY, Zhang JR, Lai SL, Zheng YY, Huang YD. Clinical outcomes of nursing interventions after endoscopic treatment for intestinal polyps and early-stage cancer. World J Gastrointest Oncol 2025; 17(10): 110667."},{"issue":"37","key":"B3","series-title":"Medicine (Baltimore)","article-title":"Comparing efficacy and factors of postoperative bleeding in endoscopic mucosal resection vs coagulation for intestinal polyps","volume":"102","author":"Li Z","year":"2023","unstructured":"Li Z, Yu F, Wang C, Du Z. Comparing efficacy and factors of postoperative bleeding in endoscopic mucosal resection vs coagulation for intestinal polyps. Medicine (Baltimore) 2023; 102(37): e34941."},{"issue":"2","key":"B4","series-title":"World J Gastrointest Surg","article-title":"Efficacy-cost analysis of endoscopic mucosal resection and cold snare polypectomy: a propensity score matching analysis","volume":"17","author":"Zhang SY","year":"2025","unstructured":"Zhang SY, Wang YC, Liu LL, Wang ZH, Guan XM. Efficacy-cost analysis of endoscopic mucosal resection and cold snare polypectomy: a propensity score matching analysis. World J Gastrointest Surg 2025; 17(2): 99510."},{"issue":"3","key":"B5","series-title":"Dis Colon Rectum","first-page":"411","article-title":"Comparison of postoperative morbidity after total colectomy with Ileorectal Anastomosis Vs proctocolectomy with IPAA in familial adenomatous polyposis","volume":"69","author":"Hendren JR","year":"2026","unstructured":"Hendren JR, Dabaghi E, Liska D, Burke CA, Macaron C, O'Malley M, et\u00a0al. Comparison of postoperative morbidity after total colectomy with Ileorectal Anastomosis Vs proctocolectomy with IPAA in familial adenomatous polyposis. Dis Colon Rectum 2026; 69(3): 411\u20139."},{"key":"B6","series-title":"Integr Cancer Ther","article-title":"A review of therapeutic effects and the pharmacological molecular mechanisms of Chinese medicine Weifuchun in treating precancerous gastric conditions","volume":"19","author":"Gu Z","year":"2020","unstructured":"Gu Z, Ling J, Cong J, Li D. A review of therapeutic effects and the pharmacological molecular mechanisms of Chinese medicine Weifuchun in treating precancerous gastric conditions. Integr Cancer Ther 2020; 19: 1534735420953215."},{"key":"B7","series-title":"J Ethnopharmacol","article-title":"Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis","volume":"303","author":"Wang B","year":"2023","unstructured":"Wang B, Zhou W, Zhang H, Wang W, Zhang B, Li S. Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis. J Ethnopharmacol 2023; 303: 115930."},{"key":"B8","series-title":"J Ethnopharmacol","article-title":"Weifuchun suppresses the malignancy of gastric cancer cells by targeting KPNA2 through miR-26a-5p-mediated destabilization and the deactivation of the MAPK signaling pathway","volume":"334","author":"Ma L","year":"2024","unstructured":"Ma L, Hu X, Zhang W, Qi D, Chen L, Yin M. Weifuchun suppresses the malignancy of gastric cancer cells by targeting KPNA2 through miR-26a-5p-mediated destabilization and the deactivation of the MAPK signaling pathway. J Ethnopharmacol 2024; 334: 118538."},{"key":"B9","series-title":"Front Cell Dev Biol","article-title":"The long non-coding RNA MALAT1 regulates intestine host-microbe interactions and polyposis","volume":"11","author":"Long T","year":"2023","unstructured":"Long T, Hernandez JE, Ma S, Steele S, Luo C, Li Y, et\u00a0al. The long non-coding RNA MALAT1 regulates intestine host-microbe interactions and polyposis. Front Cell Dev Biol 2023; 11: 1168693."},{"key":"B10","series-title":"Front Cell Infect Microbiol","article-title":"The mechanism of berberine alleviating metabolic disorder based on gut microbiome","volume":"12","author":"Wang H","year":"2022","unstructured":"Wang H, Zhang H, Gao Z, Zhang Q, Gu C. The mechanism of berberine alleviating metabolic disorder based on gut microbiome. Front Cell Infect Microbiol 2022; 12: 854885."},{"issue":"45","key":"B11","series-title":"Medicine (Baltimore)","article-title":"Weifuchun alters tongue flora and decreases serum trefoil factor I levels in gastric intestinal metaplasia: a CONSORT-compliant article","volume":"101","author":"Hua Z","year":"2022","unstructured":"Hua Z, Shen R, Lu B, Li M, Zhou P, Wu J, et\u00a0al. Weifuchun alters tongue flora and decreases serum trefoil factor I levels in gastric intestinal metaplasia: a CONSORT-compliant article. Medicine (Baltimore) 2022; 101(45): e31407."},{"issue":"3","key":"B12","series-title":"Endoscopy","first-page":"270","article-title":"Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline","volume":"49","author":"Ferlitsch M","year":"2017","unstructured":"Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, et\u00a0al. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy 2017; 49(3): 270\u201397."},{"issue":"3","key":"B13","series-title":"J Med Clin Res","first-page":"422","article-title":"Clinical efficacy of traditional Chinese medicine retention enema in the treatment of recurrent patients after colon polypectomy","volume":"43","author":"Song PJ","year":"2026","unstructured":"Song PJ, Wang SY. Clinical efficacy of traditional Chinese medicine retention enema in the treatment of recurrent patients after colon polypectomy. J Med Clin Res 2026; 43(3): 422\u2013424."},{"issue":"4","key":"B14","series-title":"ANZ J Surg","first-page":"697","article-title":"Comparing return of bowel function after right versus extended right hemicolectomy: a retrospective analysis","volume":"94","author":"Maas Z","year":"2024","unstructured":"Maas Z, Carson DA, McIntyre RA, Rahiri JL, Wells C, Cribb B, et\u00a0al. Comparing return of bowel function after right versus extended right hemicolectomy: a retrospective analysis. ANZ J Surg 2024; 94(4): 697\u2013701."},{"issue":"1","key":"B15","series-title":"Chin Med","first-page":"120","article-title":"A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer","volume":"16","author":"Bian Y","year":"2021","unstructured":"Bian Y, Chen X, Cao H, Xie D, Zhu M, Yuan N, et\u00a0al. A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer. Chin Med 2021; 16(1): 120."},{"key":"B16","series-title":"J Chromatogr B Analyt Technol Biomed Life Sci","first-page":"112","article-title":"Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS\/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet","volume":"1000","author":"Jin Y","year":"2015","unstructured":"Jin Y, Tian T, Ma Y, Xu H, Du Y. Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS\/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet. J Chromatogr B Analyt Technol Biomed Life Sci 2015; 1000: 112\u20139."},{"issue":"3","key":"B17","series-title":"Chin J Basic Med Traditional Chin Med","first-page":"489","article-title":"Effect of Weifuchun on gastric mucosal flora in patients with gastric intestinal metaplasia","volume":"30","author":"Shen R","year":"2024","unstructured":"Shen R, Xiao L, Hua ZL, Lu B, Li MF, Zhou P, et\u00a0al. Effect of Weifuchun on gastric mucosal flora in patients with gastric intestinal metaplasia. Chin J Basic Med Traditional Chin Med 2024; 30(3): 489\u2013494."},{"key":"B18","series-title":"Efficacy of Weifuchun combined with folic acid and Helicobacter pylori eradication therapy in the treatment of Helicobacter pylori-positive chronic atrophic gastritis","author":"Huang SY","year":"2025","unstructured":"Huang SY. Efficacy of Weifuchun combined with folic acid and Helicobacter pylori eradication therapy in the treatment of Helicobacter pylori-positive chronic atrophic gastritis; 2025."},{"issue":"3","key":"B19","series-title":"World Chin J Digestology","first-page":"225","article-title":"Network pharmacology study and molecular docking on the mechanism of Weifuchun in the treatment of colorectal cancer","volume":"33","author":"Yang Y","year":"2025","unstructured":"Yang Y, Zhao TT, Liu ZH. Network pharmacology study and molecular docking on the mechanism of Weifuchun in the treatment of colorectal cancer. World Chin J Digestology 2025; 33(3): 225\u2013234."},{"issue":"5","key":"B20","series-title":"Chin J Gastroenterol Hepatol","first-page":"518","article-title":"Efficacy observation of Weifuchun capsules combined with dual therapy for Helicobacter pylori eradication","volume":"33","author":"Zhang H","year":"2024","unstructured":"Zhang H, Peng B, Zhang CX, Luo HS. Efficacy observation of Weifuchun capsules combined with dual therapy for Helicobacter pylori eradication. Chin J Gastroenterol Hepatol 2024; 33(5): 518\u2013521."},{"issue":"9","key":"B21","series-title":"Chin Traditional Patent Med","article-title":"Clinical efficacy of Weifuchun capsules combined with omeprazole in treating patients with chronic non-atrophic gastritis of spleen-qi deficiency syndrome","author":"Ji CF","year":"2025","unstructured":"Ji CF, Zhao LY, Zhong XW. Clinical efficacy of Weifuchun capsules combined with omeprazole in treating patients with chronic non-atrophic gastritis of spleen-qi deficiency syndrome. Chin Traditional Patent Med 2025; 9."},{"issue":"4","key":"B22","series-title":"Chin J Gen Pract","first-page":"597","article-title":"Clinical efficacy of Weifuchun tablets combined with omeprazole enteric-coated capsules in the treatment of functional dyspepsia","volume":"22","author":"Kang NS","year":"2024","unstructured":"Kang NS, Huang J, Qian R, Gu HP, Han XF, Su WT. Clinical efficacy of Weifuchun tablets combined with omeprazole enteric-coated capsules in the treatment of functional dyspepsia. Chin J Gen Pract 2024; 22(4): 597\u2013600."},{"key":"B23","series-title":"Front Microbiol","article-title":"Gut microbiome modulation by Weifuchun Capsules alleviates chronic atrophic gastritis: a combined microbiota and metabolomics approach","volume":"16","author":"Xie W","year":"2025","unstructured":"Xie W, Wang N, Wang M, Zhang Q, Li W, Zhang H, et\u00a0al. Gut microbiome modulation by Weifuchun Capsules alleviates chronic atrophic gastritis: a combined microbiota and metabolomics approach. Front Microbiol 2025; 16: 1634410."},{"key":"bib24","series-title":"Acta Microbiol Immunol Hung","doi-asserted-by":"publisher","DOI":"10.1556\/030.2026.02892","article-title":"Integrative analysis of the gut-liver-heart axis in coronary artery disease: from chronic metabolic dysbiosis to acute cardiogenic shock","author":"Khan MS","year":"2026","unstructured":"Khan MS, Khan MN, Umair SM, Luo S, Huang B. Integrative analysis of the gut-liver-heart axis in coronary artery disease: from chronic metabolic dysbiosis to acute cardiogenic shock. 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