{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:25:40Z","timestamp":1773717940832,"version":"3.50.1"},"reference-count":36,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2018,11,22]]},"abstract":"<jats:p>Transforming growth factor \u03b2 1 (TGFB1) likely contributes to the pathogenesis of Epstein-Barr virus (EBV)-mediated cancer. A microarray containing 59 probes for detecting mRNA of members of TGFB1-associated pathways was developed. mRNA expression of TGFB1 receptors and members of connected pathways were examined in peripheral blood leukocytes of patients during acute EBV infection and after recovery. <jats:italic>TGFB1<\/jats:italic> and <jats:italic>TGFBR2<\/jats:italic> mRNA expression was increased in patients with EBV infection. Similarly, mRNA expression of protein kinase C (<jats:italic>PRKCB<\/jats:italic>), <jats:italic>MAP3K7, PDLIM7<\/jats:italic>, and other members of TGFB1 and NF-\u03baB signaling pathways increased. A shift of mRNA transcript variant expression of some key members (<jats:italic>TGFBR2, PRKCB<\/jats:italic>, and <jats:italic>NFKBIB<\/jats:italic>) of involved signaling pathways was detected. After the patients\u2019 recovery, most of the altered mRNA expression has been normalized. We speculate that in patients with EBV infection, members of TGFB1-associated pathways contribute to the suppression of proapoptotic and induction of pro-survival factors in leukocytes. The modulation of TGFB1-associated pathways may be considered as a potential risk factor in the development of EBV-associated tumors in patients with acute EBV infection.<\/jats:p>","DOI":"10.1556\/030.65.2018.047","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T11:04:55Z","timestamp":1542884695000},"page":"247-254","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["Changes in mRNA expression of members of TGFB1-associated pathways in human leukocytes during EBV infection"],"prefix":"10.1556","volume":"66","author":[{"given":"Elena Nikolaevna","family":"Filatova","sequence":"first","affiliation":[{"name":"1 Laboratory of Molecular Biology and Biotechnology, Blokhina Scientific Research Institute of Epidemiology and Microbiology of Nizhny Novgorod, Nizhny Novgorod, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay Aleksandrovich","family":"Sakharnov","sequence":"additional","affiliation":[{"name":"1 Laboratory of Molecular Biology and Biotechnology, Blokhina Scientific Research Institute of Epidemiology and Microbiology of Nizhny Novgorod, Nizhny Novgorod, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry Igorevich","family":"Knyazev","sequence":"additional","affiliation":[{"name":"1 Laboratory of Molecular Biology and Biotechnology, Blokhina Scientific Research Institute of Epidemiology and Microbiology of Nizhny Novgorod, Nizhny Novgorod, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg Vladimirovich","family":"Utkin","sequence":"additional","affiliation":[{"name":"1 Laboratory of Molecular Biology and Biotechnology, Blokhina Scientific Research Institute of Epidemiology and Microbiology of Nizhny Novgorod, Nizhny Novgorod, Russian 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