{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:14:58Z","timestamp":1760267698455},"reference-count":76,"publisher":"Akademiai Kiado Zrt.","issue":"2","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:p>As an important global health challenge, diarrhea kills nearly two million people each year. Postinfectious irritable bowel syndrome (IBS) usually manifests itself as the diarrhea-predominant subtype. Small intestinal bacterial overgrowth has been observed more frequently in patients with IBS compared to healthy controls. However, the pathophysiology of IBS is not fully understood, and based on recent evidences, altered gut microbiota is involved in the pathogenesis of IBS. Therefore, we aimed to compare the microbiome in hospitalized patients with diarrhea and healthy individuals. Thirty patients and 10 healthy controls were included into this case\u2013control study. Microbial count was performed using quantitative real-time polymerase chain reaction method using bacterial 16S rRNA gene. <jats:italic>Clostridium cluster IV<\/jats:italic> and <jats:italic>Bacteroides<\/jats:italic> were significantly more frequent in the patients compared with the healthy individuals (<jats:italic>p<\/jats:italic>\u2009=\u20090.02 and 0.023, respectively). However, the quantity of <jats:italic>Enterococcus<\/jats:italic> and <jats:italic>Bifidobacterium<\/jats:italic> groups were significantly higher in healthy controls than in diarrheal group (<jats:italic>p<\/jats:italic>\u2009=\u20090.000076 and 0.001, respectively). The results showed that the number of bacteria in all bacterial groups was significantly different between healthy individuals and diabetic group, whereas the difference between the healthy group and IBS was not significant for <jats:italic>Bifidobacterium<\/jats:italic> group. The findings of this study outlined the relationship between diarrhea, IBS, and diabetes disease and bacterial composition. It could be concluded that modifying the bacterial composition by probiotics can be helpful in the control and management of the mentioned disease.<\/jats:p>","DOI":"10.1556\/030.66.2019.002","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T11:39:36Z","timestamp":1557229176000},"page":"189-202","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":8,"title":["Identification of an intestinal microbiota signature associated with hospitalized patients with diarrhea"],"prefix":"10.1556","volume":"66","author":[{"given":"Nima","family":"Mohammadzadeh","sequence":"first","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrooz Sadeghi","family":"Kalani","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Bolori","sequence":"additional","affiliation":[{"name":"2 Department of Microbiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Azadegan","sequence":"additional","affiliation":[{"name":"3 Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsaneh","family":"Gholami","sequence":"additional","affiliation":[{"name":"4 Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rokhsareh","family":"Mohammadzadeh","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faramarz","family":"Masjedian Jazi","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref651","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1053\/j.gastro.2011.07.043","article-title":"Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome","volume":"141","author":"Rajili\u0107-Stojanovi\u0107","year":"2011","journal-title":"Gastroenterology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.gtc.2005.02.007","article-title":"Is irritable bowel syndrome a low-grade inflammatory bowel disease?","volume":"34","author":"Bercik","year":"2005","journal-title":"Gastroenterol Clin North 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