{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:33:05Z","timestamp":1785202385776,"version":"3.55.0"},"reference-count":78,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"\n Klebsiella pneumoniae<\/jats:italic> is among the most important causes of urinary tract infection (UTI). The aim of this study was to investigate the prevalence and correlation of antibiotic resistance with virulence characteristics and genetic diversity in K. pneumoniae<\/jats:italic> isolated from UTIs in Iran. Phenotypic tests and antibiotic susceptibility were carried out on the isolates. Detection of the virulence and extended-spectrum \u03b2-lactamase (ESBL) genes was performed by polymerase chain reaction. Pulsed-\ufb01eld gel electrophoresis (PFGE) was used for exploring the genomic relatedness. Hemolysin, biofilm, and hypermucoviscosity formation were observed in 87.1%, 86.4%, and 12.1% of isolates, respectively. The antibiotic resistance rate of K. pneumoniae<\/jats:italic> isolates ranged from 12.1% for meropenem to 100% for amoxicillin. The prevalence of virulence genes ranged from 1.4% for cnf-1<\/jats:italic> to 100% for mrkD<\/jats:italic>, fimH<\/jats:italic>, kpn<\/jats:italic>, and entB<\/jats:italic> genes. In this study, 91.7%, 33.3%, and 4.2% of phenotypically ESBL-producers were positive for bla<\/jats:italic>CTX-M<\/jats:sub>, bla<\/jats:italic>TEM<\/jats:sub>, and bla<\/jats:italic>SHV<\/jats:sub> genes, respectively. An association was observed between the presence of traT<\/jats:italic>, fyuA,<\/jats:italic> or cnf<\/jats:italic>-1 genes with antibiotic resistance. Two clone types were obtained by PFGE that indicate different K. pneumoniae<\/jats:italic> clones in community- and hospital-acquired UTIs. The findings of this study are valuable in development of treatment strategies against UTIs in Iran.<\/jats:p>","DOI":"10.1556\/030.66.2019.006","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T09:26:55Z","timestamp":1551173215000},"page":"349-366","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":26,"title":["Antibiotic resistance, virulence and genetic diversity of Klebsiella pneumoniae in community- and hospital-acquired urinary tract infections in Iran"],"prefix":"10.1556","volume":"66","author":[{"given":"Fatemeh","family":"Eghbalpoor","sequence":"first","affiliation":[{"name":"1 Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehri","family":"Habibi","sequence":"additional","affiliation":[{"name":"1 Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Azizi","sequence":"additional","affiliation":[{"name":"2 Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Asadi Karam","sequence":"additional","affiliation":[{"name":"1 Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Bouzari","sequence":"additional","affiliation":[{"name":"1 Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref631","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12879-017-2296-x","article-title":"Antimicrobial susceptibilities of aerobic and facultative Gram-negative bacilli isolated from Chinese patients 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