{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T08:28:35Z","timestamp":1719736115348},"reference-count":52,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["AMicr"],"published-print":{"date-parts":[[2019,12,13]]},"abstract":"Aminoglycosides are widely recommended for treatment of Acinetobacter baumannii<\/jats:italic> infections in combination with \u03b2-lactams or quinolones. This cross-sectional study was aimed to investigate the coexistence of aminoglycoside modifying enzyme (AME) genes among A. baumannii<\/jats:italic> isolates from clinical samples in Ahvaz, Iran. A total of 85 clinical A. baumannii<\/jats:italic> isolates typed by ERIC-PCR were investigated for the presence of AME genes, including ant(3\u2033)-Ia<\/jats:italic>, aac(6\u2032)-Ib<\/jats:italic>, aac(3\u2032)-Ia<\/jats:italic>, ant(2\u2033)-Ia<\/jats:italic>, and aph(3\u2032)-VIa<\/jats:italic> by PCR. The resistance rates to aminoglycoside agents were evaluated by disk diffusion. In this study, 84 out of 85 A. baumannii<\/jats:italic> isolates were resistant to at least one of the aminoglycosides and harbored at least one AME gene. The most common gene encoding AMEs was aph (3\u2032)VIa<\/jats:italic>, followed by aac(3\u2032)-Ia<\/jats:italic>, ant(3\u2033)-Ia<\/jats:italic>, ant (2\u2033)-Ia<\/jats:italic>, and aac(6\u2032)-Ib<\/jats:italic>. The aminoglycoside-resistant genotypes were completely matched to resistant phenotypes to each one of the aminoglycoside agents. There was a clear association between AME gene types and the phenotype of resistance to aminoglycosides with their ERIC-PCR types. Our findings highlight the coexistence of AME genes and clonal dissemination of multiresistant A. baumannii<\/jats:italic> in hospital setting.<\/jats:p>","DOI":"10.1556\/030.66.2019.042","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:57:52Z","timestamp":1576241872000},"page":"33-41","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["Coexistence of genes encoding aminoglycoside modifying enzymes among clinical Acinetobacter baumannii isolates in Ahvaz, Southwest Iran"],"prefix":"10.1556","volume":"67","author":[{"given":"Farkhondeh Saleh","family":"Shooshtari","sequence":"first","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"2 Infertility Research and Treatment Center of Jahad Daneshgahi, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Navidifar","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Amin","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"3 Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 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