{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:46:58Z","timestamp":1789001218212,"version":"build-2803163510"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica Hungarica"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>The glomerular filtration barrier is a highly specialized tri-layer structure with unique functional properties. Podocyte dysfunction and cytoskeletal disorganization leads to disruption of the slit diaphragma, and proteinuria. Inflammatory diseases involving the kidney as well as inherited podocytopathies or diabetic nephropathy cause injury of the podocyte network. Focal segmental glomerulosclerosis (FSGS) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children. Several causative genes have been identified in the pathogenesis of FSGS. Mutations of the transient receptor potential canonical-6 (TRPC6), a non-selective cation channel that is directly activated by diacylglycerol (DAG), cause a particularly aggressive form of FSGS. Angiotensin II, acting through its AT1 receptor, plays a critical role in generation of proteinuria and progression of kidney injury in a number of kidney diseases, including FSGS. Mounting evidence suggest the central role of TRPC6 and perhaps other TRPC channels in the pathogenesis of FSGS as well as of acquired forms of proteinuria such as diabetic nephropathy or hypertension. Identification of signaling pathways downstream of TRPC6 may provide novel targets for the treatment of proteinuria and prevent progression of podocyte injury.<\/jats:p>","DOI":"10.1556\/036.102.2015.3.2","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T03:24:41Z","timestamp":1443065081000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of TRPC6 ion channels in podocytes \u2014 Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases"],"prefix":"10.1556","volume":"102","author":[{"given":"T","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Medical Faculty, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ambrus","sequence":"additional","affiliation":[{"name":"DE-MTA \u201cLend\u00fclet\u201d Cellular Physiology Research Group, Department of Physiology, Medical Faculty, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Z\u00e1k\u00e1ny","sequence":"additional","affiliation":[{"name":"DE-MTA \u201cLend\u00fclet\u201d Cellular Physiology Research Group, Department of Physiology, Medical Faculty, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical Faculty, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"B\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"DE-MTA \u201cLend\u00fclet\u201d Cellular Physiology Research Group, Department of Physiology, Medical Faculty, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Acta Physiologica Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/036\/102\/3\/article-p241.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/036\/102\/3\/article-p241.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/036\/102\/3\/article-p241.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:50:44Z","timestamp":1704297044000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/036\/102\/3\/article-p241.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/036.102.2015.3.2","relation":{},"ISSN":["0231-424X","1588-2683"],"issn-type":[{"value":"0231-424X","type":"print"},{"value":"1588-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}