{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:36:49Z","timestamp":1781703409783,"version":"3.54.5"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Acta Physiologica Hungarica"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>To investigate whether heat stress attenuates skeletal muscle atrophy of the extensor digitorum longus (EDL) muscle in streptozotocin-induced diabetic rats, 12-week-old male Wistar rats were randomly assigned to four groups (<jats:italic>n<\/jats:italic> = 6 per group): control (Con), heat stress (HS), diabetes mellitus (DM), and diabetes mellitus\/heat stress (DM + HS). Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg\/kg). Heat stress was induced in the HS and DM + HS groups by immersion of the lower half of the body in hot water at 42 \u00b0C for 30 min; it was initiated 7 days after injection of streptozotocin, and was performed once a day, five times a week for 3 weeks. The muscle fiber cross-sectional area of EDL muscles from diabetic and non-diabetic rats was determined; heat stress protein (HSP) 72 and HSP25 expression levels were also analyzed by western blotting. Diabetes-induced muscle fiber atrophy was attenuated upon heat stress treatment in diabetic rats. HSP72 and HSP25 expression was upregulated in the DM + HS group compared with the DM group. Our findings suggest that heat stress attenuates atrophy of the EDL muscle by upregulating HSP72 and HSP25 expression.<\/jats:p>","DOI":"10.1556\/036.102.2015.3.7","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T03:24:41Z","timestamp":1443065081000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":9,"title":["Heat stress attenuates skeletal muscle atrophy of extensor digitorum longus in streptozotocin-induced diabetic rats"],"prefix":"10.1556","volume":"102","author":[{"given":"K","family":"Nonaka","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Osaka Prefecture University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Une","sequence":"additional","affiliation":[{"name":"Department of Living Science, Shujitsu Junior College, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Kibi International University, Takahashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Acta Physiologica Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/036\/102\/3\/article-p293.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/036\/102\/3\/article-p293.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/036\/102\/3\/article-p293.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T15:50:42Z","timestamp":1704297042000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/036\/102\/3\/article-p293.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1556\/036.102.2015.3.7","relation":{},"ISSN":["0231-424X","1588-2683"],"issn-type":[{"value":"0231-424X","type":"print"},{"value":"1588-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}