{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:09:27Z","timestamp":1747199367539,"version":"3.40.5"},"reference-count":53,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2022,6,20]]},"abstract":"Az eml\u0151daganatok onkoseb\u00e9szeti kezel\u00e9s\u00e9hez szorosan hozz\u00e1tartozik az \u00e1tt\u00e9tes h\u00f3nalji nyirokcsom\u00f3k elt\u00e1vol\u00edt\u00e1sa is. Az ut\u00f3bbi 30 \u00e9vben a h\u00f3naljnyirokcsom\u00f3k diagnosztik\u00e1ja, kezel\u00e9se is nagym\u00e9rt\u00e9k\u0171 v\u00e1ltoz\u00e1son ment kereszt\u00fcl. A sentinel nyirokcsom\u00f3-biopsia 1993-as bevezet\u00e9se a betegek jelent\u0151s r\u00e9sz\u00e9n\u00e9l biztons\u00e1gosan elhagyhat\u00f3v\u00e1 tette a nagy morbidit\u00e1ssal j\u00e1r\u00f3 axill\u00e1ris blockdissecti\u00f3t, \u00e9s hasonl\u00f3k\u00e9ppen szignifik\u00e1nsan pontosabb\u00e1 v\u00e1lt az eml\u0151daganatok st\u00e1diummeghat\u00e1roz\u00e1sa \u00e9s \u00edgy az onkol\u00f3giai, komplex kezel\u00e9s is. Az \u0151rszemnyirokcsom\u00f3-biopsia bevezet\u00e9se ut\u00e1n nem sokkal megjelent az \u0151rszemnyirokcsom\u00f3 intraoperat\u00edv vizsg\u00e1lata (pl.: inprint citol\u00f3gia) is, mely m\u00e1r a k\u00e9t \u00fcl\u00e9sben v\u00e9gzett m\u0171t\u00e9tek sz\u00e1m\u00e1t, ez\u00e1ltal a betegek megterhel\u00e9s\u00e9t \u00e9s a m\u0171t\u00e9ti k\u00f6lts\u00e9geket is jelent\u0151sen cs\u00f6kkentette.<\/jats:p>\n Saj\u00e1t vizsg\u00e1latunk eredm\u00e9nye r\u00e1mutat, hogy az axilla kezel\u00e9s\u00e9ben az axill\u00e1ris blockdissectio elv\u00e9gz\u00e9se a betegek egyre kisebb csoportj\u00e1n\u00e1l sz\u00fcks\u00e9ges, \u00e9s ez az ar\u00e1ny a j\u00f6v\u0151ben tov\u00e1bb fog cs\u00f6kkeni, az alternat\u00edv h\u00f3nalji sug\u00e1rkezel\u00e9s egyre sz\u00e9lesebb k\u00f6r\u0171 alkalmaz\u00e1s\u00e1val is.<\/jats:p>\n A sentinel nyirokcsom\u00f3 imprint citol\u00f3giai vizsg\u00e1lata, a jelenlegi ir\u00e1nyelvek figyelembev\u00e9tel\u00e9vel, m\u00e1r nem j\u00e1r igazolhat\u00f3 el\u0151ny\u00f6kkel, rutinszer\u0171 alkalmaz\u00e1sa nem indokolt. A legfrissebb nemzetk\u00f6zi aj\u00e1nl\u00e1sok alapj\u00e1n mastectomia kapcs\u00e1n (amikor posztoperat\u00edv sug\u00e1rkezel\u00e9st nem tervez\u00fcnk), valamint neoadjuv\u00e1ns kezel\u00e9st k\u00f6vet\u0151en lehet indik\u00e1lt az \u0151rszemnyirokcsom\u00f3 intraoperat\u00edv vizsg\u00e1lata.<\/jats:p>\n Eredm\u00e9nyeink szerint a preoperat\u00edv axill\u00e1ris ultrahangvizsg\u00e1lat sor\u00e1n a gyan\u00fas nyirokcsom\u00f3k \u00e9szlel\u00e9se el\u0151re jelezheti a betegs\u00e9g st\u00e1dium\u00e1t. A kutat\u00e1si eredm\u00e9nyeink alapj\u00e1n a neoadjuv\u00e1ns kezel\u00e9sben r\u00e9szes\u00fclt betegek eset\u00e9n siker\u00fclt igazolnunk, hogy a preoperat\u00edv daganatm\u00e9ret (\u226420\u2009mm, P<\/jats:italic> = 0,002) mellett a preoperat\u00edv nyirokcsom\u00f3m\u00e9ret (\u226415\u2009mm, P<\/jats:italic> = 0,04) alapj\u00e1n j\u00f3solhat\u00f3 meg, hogy a betegs\u00e9g N0-1-es st\u00e1tusz\u00fa.<\/jats:p>","DOI":"10.1556\/1046.2022.20012","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T15:51:08Z","timestamp":1655913068000},"page":"169-178","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":0,"title":["\u00daj trendek az axilla seb\u00e9szi kezel\u00e9s\u00e9ben eml\u0151r\u00e1k eset\u00e9n"],"prefix":"10.1556","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-4975","authenticated-orcid":true,"given":"Zolt\u00e1n","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Prof. Dr. L\u00e1z\u00e1r Gy\u00f6rgy)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Paszt","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Prof. Dr. L\u00e1z\u00e1r Gy\u00f6rgy)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Simonka","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika, 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Kar, Pathol\u00f3giai Int\u00e9zet, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Prof. Dr. Tiszlavicz L\u00e1szl\u00f3)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"V\u00f6r\u00f6s","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Pathol\u00f3giai Int\u00e9zet, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Prof. Dr. Tiszlavicz L\u00e1szl\u00f3)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Orm\u00e1ndi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Radiol\u00f3giai Klinika, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Dr. Kincses Zsigmond Tam\u00e1s)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Fejes","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Radiol\u00f3giai Klinika, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Dr. Kincses Zsigmond Tam\u00e1s)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Onkoter\u00e1pi\u00e1s Klinika, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Prof. Dr. Ol\u00e1h Judit)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem Szent-Gy\u00f6rgyi Albert Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika, Szeged, Magyarorsz\u00e1g (tansz\u00e9kvezet\u0151: Prof. Dr. L\u00e1z\u00e1r Gy\u00f6rgy)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Ann 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Ann Surg Oncol \n 2017; 24: 3004\u20133010."},{"key":"B32","series-title":"Eur J Surg Oncol","first-page":"945","article-title":"Preoperative predictors of high and low axillary nodal burden in Z0011 eligible breast cancer patients with a positive lymph node needle biopsy result","volume":"44","author":"Lim \n GH","year":"2018","unstructured":"Lim \n GH\n , \n Upadhyaya \n VS\n , \n Acosta \n HA\n , \n Lim \n JMA\n , \n Allen \n JC \n Jr\n , \n Leong \n LCH\n \n . Preoperative predictors of high and low axillary nodal burden in Z0011 eligible breast cancer patients with a positive lymph node needle biopsy result. 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Br J Surg \n 2017; 104: 1811\u20131815."},{"key":"B34","series-title":"PLoS One","article-title":"Could axillary clearance be avoided in clinically node-negative breast cancer patients with positive nodes diagnosed by ultrasound guided biopsy in the post-ACOSOG Z0011 era?","volume":"14","author":"Miao \n Liu","year":"2019","unstructured":"Miao \n Liu\n , \n Yang \n Yang\n , \n Fei \n Xie\n , \n Jiagia \n Guo\n , \n Siyuan \n Wang\n , \n Houpu \n Yang\n , et\u00a0al.\n \n Could axillary clearance be avoided in clinically node-negative breast cancer patients with positive nodes diagnosed by ultrasound guided biopsy in the post-ACOSOG Z0011 era? \n PLoS One \n 2019; 14: e0210437."},{"key":"B35","series-title":"World J Surg Oncol","first-page":"37","article-title":"Higher axillary lymph node metastasis burden in breast cancer patients with positive preoperative node biopsy: may not be appropriate to receive sentinel lymph node biopsy in the post-ACOSOG Z0011 trial era","volume":"17","author":"Liang \n Y","year":"2019","unstructured":"Liang \n Y\n , \n Chen \n X\n , \n Tong \n Y\n , \n Zhan \n W\n , \n Zhu \n Y\n , \n Wu \n J\n , et\u00a0al.\n \n Higher axillary lymph node metastasis burden in breast cancer patients with positive preoperative node biopsy: may not be appropriate to receive sentinel lymph node biopsy in the post-ACOSOG Z0011 trial era. 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Results of a prospective study","volume":"23","author":"Mamtani \n A","year":"2016","unstructured":"Mamtani \n A\n , \n Barrio \n AV\n , \n King \n TA\n , \n Van Zee \n KJ\n , \n Plitas \n G\n , \n Pilewskie \n M\n , et\u00a0al.\n \n How often does neoadjuvant chemotherapy avoid axillary dissection in patients with histologically confirmed nodal metastases? Results of a prospective study. Ann Surg Oncol \n 2016; 23: 3467\u20133474."},{"key":"B51","series-title":"Ann Surg Oncol","first-page":"3527","article-title":"The optimal treatment plan to avoid axillary lymph node dissection in early-stage breast cancer patients differs by surgical strategy and tumor subtype","volume":"24","author":"Pilewskie \n M","year":"2017","unstructured":"Pilewskie \n M\n , \n Zabor \n EC\n , \n Mamtani \n A\n , \n Barrio \n A\n , \n Stempel \n M\n , \n Morrow \n M\n \n . 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Ann Surg Oncol \n 2017; 24: 3011\u20133016."}],"container-title":["Magyar Seb\u00e9szet"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/1046\/75\/2\/article-p169.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/1046\/75\/2\/article-p169.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/1046\/75\/2\/article-p169.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T10:40:52Z","timestamp":1676976052000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/1046\/75\/2\/article-p169.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":53,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1556\/1046.2022.20012","relation":{},"ISSN":["0025-0295","1789-4301"],"issn-type":[{"type":"print","value":"0025-0295"},{"type":"electronic","value":"1789-4301"}],"subject":[],"published":{"date-parts":[[2022,6,20]]}}}