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The recently-developed technique of creating organoids from somatic stem cells has created a challenging opportunity to develop a treatment that involves the creation of a substitute small intestine using autologous cells instead of transplanting another individual's small intestines. The remaining partial large intestine is then used as a segmental graft, and autologous small intestinal organoid transplantation is conducted on its epithelium in order to create a pedunculated hybrid graft. This is a new surgical technique for interposing with the original ileocecal region. The hybrid large intestine acquires both the lymphatic vessels that are involved in nutrient absorption and the original peristaltic function of the large intestine.<\/jats:p><jats:p>This lecture touches upon the history of the development of organoid medicine, after which an introduction is provided of the revolutionary surgical technique in which a functional small intestine is created by regenerating autologous cells.<\/jats:p><jats:p>The content here was introduced in a special lecture (online) at the 29th Congress of the Experimental Surgical Session of the Hungarian Surgical Society (Host: Dr. Norbert Nemeth, 9\/9\/2022, Budapest).<\/jats:p>","DOI":"10.1556\/1046.2022.40002","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T10:54:26Z","timestamp":1671015266000},"page":"261-264","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["A new stage of experimental surgery for organoid based intestinal regeneration \u2013 A review of organoid research and recent advance"],"prefix":"10.1556","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-3778","authenticated-orcid":true,"given":"Kobayashi","family":"Eiji","sequence":"first","affiliation":[{"name":"Department of Kidney Regenerative Medicine, Industry-Academia Collaborative Department, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"B1","series-title":"Clin Nutr ESPEN","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.clnesp.2021.07.004","article-title":"Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: an international multicenter survey","volume":"45","author":"Pironi L","year":"2021 Oct","unstructured":"Pironi L, Steiger E, Joly F, Jeppesen PB, Wanten G, Sasdelli AS, et\u00a0al. 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